...Janine Gottier Nwafor; Marta Nowik; Naohiko Anzai; Hitoshi Endou; Carsten A. Wagner Introduction: The kidneys play a central role in eliminating metabolic waste products and drugs through transporter-mediated excretion along the proximal tubule. This task is mostly achieved through a variety...

... grade proximal tubular injury is present in SLN because the proximal tubule is the main site of uric acid and sodium transport. Methods: Five subjects with SLN were compared to four subjects with recurrent hyponatremia and three healthy individuals. Urinary NGAL (neutrophil gelatinase associated...

.... Proximal tubule Reabsorption of phosphate Phosphate sensing OK cells Renal reabsorption of inorganic phosphate (Pi) is the main mechanism by which mammals keep their plasma levels of Pi constant (for review see [ 1,2 ]). This process takes place to a major extent along the proximal tubule...

.... Na + Phosphate cotransporter FGF23 Bone density Proximal tubule Oxidative stress-response kinase Original Paper Kidney Blood Press Res 2012;36:149-161 DOI: 10.1159/000343405 Published online: October 26, 2012 © 2012 S. Karger AG, Basel www.karger.com/kbr PAactcheaprete/Fdö: lOlecrt...

...J. Biber; H. Murer Kidney Proximal tubule Transport Phosphate Expression cloning 11 11 2008 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form...

...Jon S. Beck; Mireille Marsolais; Josette Nöel; Sylvie Breton; Raynald Laprade The elevation in oxygen consumption (QO 2 ) observed following addition of the sodium ionophore nystatin in suspensions of rabbit renal proximal tubules was significantly increased by 1 m M dibutyryl cyclic adenosine...

... and S3 of the proximal tubule by an ultramicroassay. Z-Phenylalanyl-arginine-7-amido-4-methylcoumarin served as a substrate. In normoproteinuric Sprague-Dawley rats, induction of acute unselective glomerular proteinuria with Adriamycin (5 mg/kg body weight) revealed a moderate activity increase...

...Karin Löffler; Johann S. Schwegler; Stefan Silbernagl The established opossum kidney (OK) cell line serves as a model system for ion and substrate transport in the renal proximal tubule. Previous experiments on OK cells revealed a channel-mediated Na + conductance which is regulated...

... in the presence of the α 2 antagonist yohimbine. These results confirm the inability of isoprenaline to stimulate adenylate cyclase in the rabbit proximal tubule and demonstrate the coupling of α 2 receptors, in an inhibitory fashion, to adenylate cyclase. The inhibitory action of the α 2 -receptor agonist...

...Zaladek Gil; Costa Silva; G. Malnic In previous investigations, it was found that rats depleted in parathyroid hormone (TPTX rats) had reduced rates of proximal bicarbonate reabsorption independent on blood calcium levels. In the present work, the role of calcium (Ca 2+ ) in rat proximal tubule...

...J. Biber; H. Murer Apical sodium-dependent transport of inorganic phosphate (Pi) in the proximal tubule plays a crucial role in renal Pi reabsorption and consequently in the maintenance of Pi homeostasis. This transport system represents a main target for acute and long-term regulation...

...Christelle Monteil; Caroline Leclere; Jean Paul Fillastre; Jean Paul Morin Glucose and insulin impact on cellular phenotype expression was assessed on rabbit proximal tubule cells in primary culture. Glycolysis, gluconeogenesis pathways and lysosomal, mitochondrial, detoxication system, apical...

..., Université Paris 7, France Effect of Glucocorticoids on Mitochondrial Oxidative Enzyme and IMa-K-ATPase Activities in the Rat Proximal Tubule and Thick Ascending Limb of Henle Key Words Mitochondrial oxidative enzymes Na-K-ATPase Proximal tubule Diluting segment Adrenalectomy Glucocorticoids Abstract...

...Michael Gekle; Stefan Silbernagl The proximal tubule of the kidney is regarded the main intrarenal target of the nephrotoxin Ochratoxin A (OTA). To gain further insight into the importance of the proximal tubule we investigated renal p -aminohippurate (PAH), inorganic phosphate (P), amino acid (AA...

..., instructions or products referred to in the content or advertisements. Brush border membrane Proximal tubule Phosphate reabsorption Parathyroid hormone Low-phosphate diet X-linked hypophosphatemia Kidney Blood Pressure Research Kidney and Blood Press Res 1996;19:151-154 Heini Murer* Marius...

.... H89, a protein kinase A inhibitor, did not affect the inhibitory action of PMA. Our data suggest that PKC activation reduces the rate of H ion secretion (bicarbonate reabsorption) in convoluted segments of rat renal proximal tubules and that phosphorylation of the Na + /H + exchanger by this kinase...

... is probably also involved in OTA-induced transformation of cultured kidney cells. Chronic OTA exposure leads to an additional reduction in the urine concentrating ability. Renal hemodynamics and the secretory function of the proximal tubule are affected by OTA after prolonged but not by acute exposure. OTA...

... with in vitro autoradiography. DuP 753, a nonpeptide Ang II antagonist specific for the AT 1 sites, potently displaced binding in glomeruli (K i = 23.9 ± 3.3 n M ) and proximal tubules (K i = 43.4 ± 17 n M ). By contrast, the AT 2 antagonists, PD 123177 and CGP 42112A, were very weak in competing for specific...

...Frank A. Gesek; Anton C. Schoolwerth Hormonal stimulation of Na + /H + exchange increased intracellular pH (pH i ) in a dose-dependent manner in proximal tubules suspended in Krebs-Henseleit buffer (KHB) supplemented with 25 m M HCO 3 - and CO 2 (KHB+HCO 3 ). The maximum increase in pH i...

... cortex Renal medulla Proximal tubule Collecting duct Renal Physiol Biochem 1989:12:302-312 © 1989 S.Karger AG. Basel 1011-6524/89/0124-0302 S2.75/0 Production of Urea from Arginine in Pars recta and Collecting Duct of the Rat Kidney Olivier Levillain Annette Hus-Citharelb, François Morel", Lise...