..., such as nephrotoxicity. Early detection of renal damage is critical in preclinical drug development. This study was aimed to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be early indicators in the assessment of Gentamycin-induced nephrotoxicity. Methods...

.... Nephrotoxicity Cisplatin Acute kidney injury Dendropanax morbifera The kidney is one of the most susceptible target organs for drug-associated toxicity because of its high perfusion rate and high capability for drug uptake and metabolism. Various types of drugs can be accumulated in kidney tissue...

..., instructions or products referred to in the content or advertisements. Hepatitis C Acute Tubular Necrosis Interferon Ribavirin Nephrotoxicity Hepatitis C virus (HCV) is a blood-borne pathogen that appears to be endemic in many countries and is the main cause of chronic liver disease worldwide...

... transplantation; however, the resultant nephrotoxicity remains a serious problem. In the present study we attempted to elucidate the mechanisms of glomerular injury induced by FK506 and the renoprotective effects of the angiotensin II receptor blocker telmisartan. Methods: Seven-week-old male Wistar rats were...

..., late effects Antineoplasm treatment Nephrotoxicity Glomerular filtration rate 3 11 2008 27 04 2009 12 6 2009 © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

..., but not rapamycin. These results suggest that the nephrotoxic effects of CsA and FK506 is likely mediated through binding to renal immunophilin and inhibiting calcineurin phosphatase. 24 10 1994 11 11 2008 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cyclosporine A Nephrotoxicity Tubulotoxicity Nephron Succinate dehydrogenase...

..., FRG Nephrotoxicity of Cyclosporine A in the Rat II. Reversible Changes in Intranephronal and Urinary Catalytic Activities of N-Acetyl-p-D-Giucosaminidase Key Words Cyclosporine A Nephrotoxicity Tubulotoxicity Nephron N-acetyl-f5-Z)-glucosaminidase Lysosomes Enzymuria Quantitative histochemistry...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ochratoxin A Proximal tubule Nephrotoxicity p -Aminohippurate Amino acids Free-flow micropuncture Original Paper...

...Lev V. Reznik; Stepan P. Gambaryan The corticosteroid, triamcinolone, was examined as a potential antagonist for the nephrotoxicity of cisplatin in female Wistar rats. The changes in renal function and renal morphology were assessed on the 3rd day after administration of cisplatin (7.5 mg/kg BW...

... cell toxicity is a major mechanism of light chain nephrotoxicity. © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ochratoxin A Nephrotoxicity Kidney pathophysiology Hemodynamics Proximal tubule Kidney Blood Pressure Research Michael Gekle Stefan...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ifosfamide Nephrotoxicity Fanconi syndrome Sodium-coupled transport...

...Martin F. Wilks; Enoch N. Kwizera; Peter H. Bach Nephrotoxic metals are thought to affect mainly the proximal tubule, but the pathophysiology of acute renal failure (ARF) caused by some of these compounds cannot be explained by damage to this part of the nephron alone. To compare toxic effects...

... for the proteinuria. Renal Physiol Biocheni 1991:14:48-54 © 1991 S. K arger AG. Basel 1011-6524/9170142 004X $2.75/0 Metabolic Heterogeneity of Isolated Cortical and Juxtamedullary Glomeruli in Adriamycin Nephrotoxicity Sabine Kästner , Martin F. Wilksb, Wilfried Gwinner , Mechthild Soose , Peter H. Bach'\ Hilmar...

... Preto, eDepartment of Clinical, Toxicological, and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil Key Words Cisplatin Acute renal failure Nephrotoxicity Inflammation Cytokines Neutrophils Glibenclamide Abstract...

... be reduced by acidification. Therefore, urinary acidification could be an option to prevent IFO nephropathy in patients. 13 07 2006 11 09 2006 22 12 2006 Ifosfamide Chloroacetaldehyde Acrolein Caspases Cathepsin B Necrosis Nephrotoxicity Thiol groups © 2006 S. Karger AG...

...Ulla Haeussler; Martin Riedel; Frieder Keller Background: The nephrotoxicity induced by contrast media remains a serious clinical problem, and the underlying mechanism has not been completely understood. Experimental and clinical investigations suggest that reactive oxygen species (ROS...

...Jan Gossmann; Androniki Radounikli; Alexander Bernemann; Oliver Schellinski; Hans-Peter Raab; Ralf Bickeböller; Ernst-Heinrich Scheuermann Background: The causes for the nephrotoxicity of cyclosporine A (CsA) have not been fully elucidated. Intrarenal vasoconstriction induced by several different...