...Kerstin Benz; Julia Schlote; Christoph Daniel; Christoph Kopp; Anke Dahlmann; Agnes Schröder; Nada Cordasic; Bernd Klanke; Karl Hilgers; Jens Titze; Kerstin Amann Background/Aims: One potential pathomechanism how low nephron number leads to hypertension in later life is altered salt handling. We...

...Ruud RG Bueters; Nicole CAJ van de Kar; Michiel F Schreuder Background: Renal size is often used as a marker for nephron numbers as estimation of glomerular numbers is not yet possible in vivo. However, the validity of an association between the two is questionable. As a proper marker for nephron...

...Julia Schlote; Agnes Schröder; Anke Dahlmann; Britta Karpe; Nada Cordasic; Christoph Daniel; Karl Friedrich Hilgers; Jens Titze; Kerstin Amann; Kerstin Benz Aims: To test the suggested association of low nephron number and later development of renal and cardiovascular disease we investigated...

... injury Renal morphology Nephron number Creatinine Stress Original Paper Kidney Blood Press Res 2011;34:424 429 DOI: 10.1159/000328331 Received: July 13, 2010 Accepted: April 1, 2011 Published online: June 28, 2011 Effects of Immobilization Stress on Kidneys of Wistar Male Rats: A Morphometrical...

..., birth-weight-matched offspring were paired. One rat from each pair was perfusion fixed at 4 weeks of age and the other rat at 40 weeks of age. Kidneys were removed and nephron number and total renal filtration surface area (FSA) determined using unbiased stereological techniques. The rats that were...