...Renato V.M. Starek; Samirah A. Gomes; Claudia M.B. Helou Introduction: The literature lacks whether metabolic alkalemia occurs in outpatients with hypercalciuric nephrolithiasis. Thus, we aim to investigate it because these patients are often treated with thiazides to reduce urinary calcium...

... aimed to delineate the molecular interplay between AKI and nephrolithiasis. Methods: A mild (20 min) and severe (30 min) renal ischemia-reperfusion injury model was established in mice. Seven days after injury, calcium oxalate stones were induced using glyoxylate (Gly) to evaluate the impact of AKI...

...Teresa Antonia Kiener; Elena Moré; Michael Franzen; Janne Cadamuro; Christoph Schwarz; Carsten Bergmann; Hermann Salmhofer Introduction: This study was designed to determine the mineral composition of calculi in nephrocalcinosis with nephrolithiasis, diagnose the underlying disease, and monitor...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Nephrolithiasis Genetics Diet Observational cohort study Biobank Kidney stones disease affects 10–15% of the population worldwide with at least one episode...

..., and inappropriately elevated urine pH. If not treated, this chronic condition eventually leads to nephrocalcinosis, nephrolithiasis, impaired renal function, and bone demineralization. dRTA is a well-defined entity that can be diagnosed by genetic testing of 5 genes known to be disease-causative. Incomplete dRTA...

... for the treatment and prevention of nephrolithiasis. [email protected] 3 05 2019 7 09 2019 22 10 2019 Nephrolithiasis has a lifetime incidence of up to 2–5% of the population in Asia, 5–9% in Europe, and 8–15% in North America [ 1, 2 ]. Once stones have formed, recurrence rates...

... stones. Thirty-five patients were evaluated and 25 of them met the inclusion criteria. Five patients presented nephrolithiasis corresponding to 20% of the study population. There were no statistically significant differences in any of the clinical or laboratory variables studied between patients...

... Macrophages Nephrolithiasis Phagocytosis Clinical dissolution therapies for the cystine and uric acid components of kidney stones have been used for >50 years [ 1, 2 ]; however, dissolution therapy for calcium oxalate crystals, which represent the majority of stone components, is not currently...

... to elevated levels of active vitamin D metabolites and, consequently, to hypercalcemia, hypercalciuria, nephrocalcinosis, and nephrolithiasis; however, monoallelic mutations have been associated only with milder phenotypes. In the present manuscript, we report the case of a young male patient who presented...

...Jiawen Zhao; Jiwen Cheng; Chengyang Li; Mingbin Xu; Chenjun Ma; Lei Qin; Kai Yi; Naikai Liao Background/Aims: Nephrolithiasis is one of the most prevalent diseases of the urinary system. Approximately 80% of human kidney stones are composed of calcium oxalate (CaOx), and hypercalciuria is one...

... of cinacalcet hydrochloride, coronary artery disease (CAD), myocardial infarction (MI), nephrolithiasis-related ESRD, and mortality. CASR rs7652589(A<G)_rs1801725(G>T) haplotypes and rs1801725 epistatic interactions with vitamin D signaling pathway genes were examined for associations with selected...

...Yunlong Liu; Quan Liu; Xiang Wang; Ziqi He; Derong Li; Xiaofeng Guan; Zhiwei Tao; Yaoliang Deng Background/Aims: Nephrolithiasis is a common and frequently occurring disease, its exact pathogenesis is remains unclear. Emerging data suggest that autophagy plays a vital role in the pathophysiological...

...Tilman Jobst-Schwan; Andrea Pannes; Karl Peter Schlingmann; Kai-Uwe Eckardt; Bodo B. Beck; Michael S. Wiesener Background/Aims: Hypercalcemia can result in nephrocalcinosis/nephrolithiasis and may lead to renal failure. Idiopathic infantile hypercalcemia is caused by mutations of the CYP24A1 gene...