...Katarzyna Pęczek; Michał Nowicki Background: Glucocorticoids are one of the most commonly used drugs for treatment of inflammatory and autoimmune diseases. Sirtuin-1 (SIRT-1) belongs to the family of proteins involved in protection against inflammation and oxidative stress. A role of SIRT-1...

.... Vasopressin stimulates the release of glucocorticoids which in turn up-regulate the serum- and glucocorticoid-inducible kinase 1 (SGK1). Moreover, dehydration upregulates the transcription factor NFAT5, which in turn stimulates SGK1 expression. SGK1 is activated by insulin, growth factors and oxidative stress...

... (PCT) and medullary thick ascending limb of the loop of Henle (mTAL). The effects of adrenalectomy (ADX) and ADX plus exogenous glucocorticoids were analyzed. The hormonal replacement was daily injections of dexamethasone (10 µg/l00 g body weight/24 h) for 5 days. ADX lowered the activity of all...

...Guido Henke; Iwan Setiawan; Christoph Böhmer; Florian Lang Background/Aim: Expression of the constitutively active form of serum and glucocorticoid-dependent kinase ( S422D SGK1) in Xenopus oocytes has recently been shown to upregulate endogenous Na + /K + -ATPase activity, an effect presumably...