...Fenglin Li; Jinling Zhang; Le Luo; Jing Hu Introduction: Diabetic nephropathy (DN) is a long-term loss of renal function occurring in the diabetic patients, leading to 5 million deaths in 2015, and this number is dramatically growing annually. Due to unsatisfied outcome of current treatment...

... Epidemiology Outcome Diabetes mellitus Diabetic nephropathy Cardiovascular disease Diabetes mellitus is a rapidly evolving global health problem that increasingly assumes epidemic proportions. Throughout the past 20 years, the global prevalence has more than tripled, with type 2 diabetes (T2DM...

...Yuanyuan Han; Liangzi Jin; Liangzhi Wang; Lan Wei; Chao Tu Introduction: Diabetic nephropathy (DN) is related to type 1 and type 2 diabetes. They are the leading cause of end-stage renal disease, but the underling specific pathogenesis of DN is not yet clear. Our study was conducted to explore how...

...Seigo Ito; Masahiro Nakashima; Takuya Ishikiriyama; Hiroyuki Nakashima; Akira Yamagata; Toshihiko Imakiire; Manabu Kinoshita; Shuhji Seki; Hiroo Kumagai; Naoki Oshima Introduction: In diabetic nephropathy (DN), mitochondrial dysfunction and leakage of mitochondrial DNA (mtDNA) are caused...

...Yan-Xia Chen; Shu-Ying Zhu; Chong Huang; Cheng-Yun Xu; Xiang-Dong Fang; Wei-Ping Tu Introduction: Diabetic nephropathy (DN) is the leading cause of kidney failure worldwide. To explore the pathogenesis and effective biological target of DN is beneficial to seeking novel treatment strategies...

...Xianjun Xue; Minjie Liu; Yulu Wang; Yanlei Yang; Zhiping Li; Ruifang Shi; Yueting Miao Background: Diabetic nephropathy is a common complication of the kidneys induced by diabetes and is the main cause of end-stage renal disease. MicroRNA-494-3p was reported to be upregulated in renal tissues...

...Gamze Aytaş; Rümeyza Kazancıoğlu; Ömer C. Elçioğlu; Meltem Gürsu; A. Serra Artan; Ayşegül Yabacı; Pinar Soysal; Kadir Bilgi; Semra Özçelik Introduction: Orthostatic hypotension (OH) affects 5–20% of the population. Our study investigates the presence of OH in diabetic nephropathy (DNP) patients...

...Xiao-Qiang Min; Yan Xie Background: Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear. Methods: Db/db diabetic mouse models and high glucose (HG)-induced human renal mesangial cells...

... between patients with diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). Methods: A total of 326 type 2 diabetes mellitus patients with renal biopsy were assigned to DN and NDRD groups. Echocardiography and Doppler ultrasound were performed to evaluate left ventricular hypertrophy (LVH...

...Andrew Smith; Vadim Iablokov; Mariafrancesca Mazza; Sonia Guarnerio; Vanna Denti; Mariia Ivanova; Martina Stella; Isabella Piga; Clizia Chinello; Bram Heijs; Peter A. van Veelen; Hallgrimur Benediktsson; Daniel A. Muruve; Fulvio Magni Introduction: Diabetic nephropathy (DN) and hypertensive...

...Jiali Yu; Rong Dong; Jingjing Da; Jiayu Li; Fuxun Yu; Yan Zha Background/Aim: Renal fibrosis is essential for the progression of diabetic nephropathy (DN). Macrophages accumulate in diabetic kidneys and are involved in epithelial-to-mesenchymal transition (EMT), a vital mechanism leading to renal...

...Xiaofang Tang; Jing You; Di Liu; Ming Xia; Liyu He; Hong Liu Background/Aims: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Microalbuminuria (MA) is widely used to predict early progressive renal function decline (ERFD) of DN in type 2 diabetes mellitus (T2D) patients...

...Yangyang Wang; Shikun Yang; Qianying Zhou; Hao Zhang; Bin Yi Background/Aims: Vitamin D (VD) is widely recognized as renal protective. However, whether VD supplementation provides benefit to patients with diabetic nephropathy (DN) remains controversial. Here, we performed a meta-analysis...

...Peng Gao; Bo Xu; Panai Song; Xuejing Zhu; Shuguang Yuan; Yashipal S. Kanwar; Lin Sun Background/Aims: Renal tubular injury plays an important role in the progression of diabetic nephropathy (DN). However, there is a lack of specific biomarkers for tubular damage in incipient DN. We have evaluated...

...Feng Liu; Siqi Zhang; Ruisi Xu; Shuohui Gao; Jian Yin Background/Aims: Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates diabetic nephropathy, but its role and mechanism in EndMT of GEnCs...

...Wei Wang Background/Aims: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated. Methods: Sixty patients with type 2 DN were...

...Yi-Chun Tsai; Chee-Siong Lee; Yi-Wen Chiu; Jia-Jung Lee; Su-Chu Lee; Ya-Ling Hsu; Mei-Chuan Kuo Background/Aims: Diabetic nephropathy is the leading cause of end-stage renal disease and accounts for 30∼40% of patients requiring maintenance dialysis, thereby increasing the burden on health insurance...

... effectiveness and safety of these drugs among diabetic nephropathy patients. Methods: This retrospective cohort study was conducted with diabetic nephropathy patients who initiated ACEI or ARB monotherapy. The primary outcome was a composite of end stage of renal disease and renal transplantation...

...Gábor Kökény; Lilla Fang; Csaba Révész; Miklós M. Mózes; Péter Vörös; Gábor Szénási; László Rosivall Background/Aims: Diabetic nephropathy remains a major clinical problem. The effects of prorenin might be adverse, but the literature data are controversial. We compared the renal effects of the (pro...

...Baoqin Zhou; Honghong Zou; Gaosi Xu Background/Aims: Clinically, there is lack of predictors for diabetic nephropathy (DN) in diabetes mellitus (DM) without microalbuminuria, macroalbuminuria or retinopathy. Methods: PubMed, Chinese Biomedical Database, Cochrane Library, EMBASE and Elsevier...