... patients with CKD. Azilsartan is a strong antihypertensive ARB, but its antiproteinuric effects are not well understood. We compared the antiproteinuric effect of azilsartan and candesartan in CKD patients in an open-label, randomized, crossover trial. Methods: A total of 111 patients were treated with 20...

...) excretion has been found to be increased in association with megalin-mediated metabolic load to the endo-lysosomal system in proximal tubular epithelial cells (PTECs) of residual nephrons. In the present study, we investigated the association between urinary iron and C-megalin in chronic kidney disease (CKD...

...Martino F. Pengo; Donatella Ioratti; Valeria Bisogni; Verdiana Ravarotto; Barbara Rossi; Luciana Bonfante; Francesca Simioni; Federico Nalesso; Giuseppe Maiolino; Lorenzo A. Calò Background/Aims: In chronic kidney disease (CKD) patients blood pressure variability (BPV) is associated with poor...

.... Newborn Congenital obstructive nephropathy Unilateral ureteral obstruction CKD Microarray MMP-12, IL-24 Original Paper Kidney Blood Press Res 2017;42:16-32 DOI: 10.1159/000464317 © 2017 The Autho©r(s2)0. 1P7ubTlhiseheAdutbhyoSr(.sK) arger AG, Basel Published online: February 28, 2017...

...Antonio Santoro; Marcora Mandreoli The pathogenesis of cardiovascular disease in CKD differs subtly from that of non-CKD patients. As renal function declines, the role and impact of treating classical risk factors may change and diminish. However, hypertension, hypercholesterolaemia and smoking...

...Carmine Zoccali; Giovanni Tripepi; Evangelia Dounousi; Francesca Mallamaci The inter-organ cross-talk and the functional integration of organ systems is an exceedingly complex process which until now has been investigated with a reductionist approach. CKD perturbs the inter-organ cross-talk...