...Alessio Mazzieri; Francesca Timio; Francesco Patera; Francesco Trepiccione; Mario Bonomini; Gianpaolo Reboldi Background: Aldosterone is the principal mineralocorticoid hormone and the final effector of the renin-angiotensin-aldosterone system. This hormone is primarily synthesized by the CYP11B2...

...Anne Myrthe C. van Vliet; Liffert Vogt; Bigina N.R. Ginos; Petra Frings-Meuthen; Martina Heer; Rik H.G. Olde Engberink Introduction: Long-term sodium balance studies show that sodium can be temporarily stored and released in tissues, mediated by circaseptan rhythms of aldosterone and cortisol...

...Tomáš Zelinka; Ondřej Petrák; Ján Rosa; Robert Holaj; Branislav Štrauch; Jiří Widimský Jr. Objective: Primary aldosteronism (PA) may present at younger age and may thus complicate pregnancy. Our aim was to identify female patients in whom PA was diagnosed after pregnancy complicated...

...Jing Qian; Jianyong Zhong; Minhua Yan; Ping Cheng; Huizhu Shi; Chuanming Hao; Yong Gu; Lingyun Lai Background/Aims: We aimed to determine if soluble α-klotho level was an indicator of chronic kidney disease (CKD) progression and whether α-klotho interacted with aldosterone during the course...

... in Ussing chamber experiments, fecal, serum and urinary Na + concentration by flame photometry, blood pressure by the tail cuff method and serum aldosterone levels by immunoassay. Results : The amiloride (50 µM)-induced deflection of the transepithelial potential difference was significantly lower and fecal...

... at least partially due to excessive formation of 1,25(OH) 2 D 3 and subsequent hyperphosphatemia. Klotho expression is inhibited by aldosterone. The present study explored the interaction of aldosterone and DOCA as well as the moderately selective mineralocorticoid receptor antagonist spironolactone...

... system by angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers ameliorated the progression of chronic renal disease. Different concepts supposed that aldosterone is involved in development and/or progression of renal diseases via interaction with a non-epithelial...

...Tomáš Zelinka; Martin Mašek; Jana Vlková; Mojmír Kasalický; David Michalský; Robert Holaj; Ondřej Petrák; Branislav Štrauch; Ján Rosa; Jana Dvořáková; Jiří Widimský, Jr. Background: Adrenal venous sampling serves as a discrimination between uni- and bilateral forms of primary aldosteronism (PA...

... weight verified and were housed in individual metabolic cages. After a 24-hour period, urine samples were collected and the urinary and water intake volumes measured. Blood samples to determine osmolality, aldosterone, corticosterone, angiotensin II, creatinine, urea, sodium and potassium levels were...

... aldosterone promotes tissue fibrosis in many organs, its contribution to peritoneal fibrosis and the underlying mechanism are poorly understood. The present study investigated the direct effect of aldosterone on cultured rat peritoneal fibroblasts (RPFs). Methods: The expression of aldosterone synthase...

... dialysis. The present study investigated the direct effect of aldosterone, which influences tissue fibrosis, and its cellular mechanism using cultured rat peritoneal mesothelial cells (RPMCs). Materials and Methods: The expression of aldosterone synthase (CYP11B2), mineralocorticoid receptors, 11β...

...Xiaoshu Cheng; Gaosi Xu A thymidine-to-cytosine substitution in the –344 promoter region of the aldosterone synthase gene (CYP11B2) has been associated with essential hypertension in some but not all studies conducted in Chinese. We performed a meta-analysis to evaluate the association of the –344C...

... by moderate increases in plasma aldosterone and urea concentrations. However, treatment with triamterene in sgk1 –/– mice (but not in sgk1 +/+ mice) led to severe, eventually lethal, body weight loss as well as increases in plasma aldosterone, urea and K + concentrations. Conclusions: SGK1 is required...

... were age- and body mass index (BMI)-matched with 21 healthy women were studied. Total renin, aldosterone levels, glucose and insulin levels were measured at basal state and during an oral glucose tolerance test in all subjects. A subgroup of women with PCOS was evaluated 6 months after metformin...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Atomic force microscopy Endothelial cells Cell volume Aldosterone Na + /H + exchange Basic Renal Research Kidney...

... that amiloride-sensitive lithium transport seen during potassium depletion is influenced by the presence of the adrenal glands, most likely due to their production of aldosterone. 12 09 1996 11 11 2008 © 1997 S. Karger AG, Basel 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

...Will W. Minuth; Michael Struck; Marianne Zwanzig; Peter Gross Cultured renal collecting duct cells from neonatal rabbit kidney were used to examine the influence of aldosterone on enyzmatic activity of citrate synthase during increase in Na + transport. Control epithelia showed citrate synthase...

...Marianne Zwanzig; Will W. Minuth; Peter Gross The effects of aldosterone on protein synthesis in the latent period were investigated on cultured renal collecting duct cells from neonatal rabbit kidneys. Tissue was incubated with radioactively labelled uridine and amino acids and then precipitated...

... commercialized as the ‘ideal’ ligand for the MCR, replacing the natural hormone aldosterone. None of the derivatives was retained for possible clinical use as an improvement over Canrenone or Spironolactone. No apparent correlation could be drawn between affinity for the MCR in vitro and biological potency...

... SGK2 and SGK3. Thus, all three kinases may participate in the regulation of Na + /K + -ATPase activity by hormones such as insulin and IGF-1. 29 11 2002 26 2 2003 Insulin Insulin-like growth factor-1 Glucocorticoids Aldosterone Na + transport Original Paper Kidney Blood Press...