Aims: It was the aim of this study to investigate the relationship between normal renal function – estimated glomerular filtration rate (GFR) – and visceral adiposity measured by CT in apparently healthy Korean women. Methods: A total of 425 apparently healthy women were recruited. We assessed body composition with CT and divided the study population into 2 groups based on fat distribution: the visceral fat dominant group and the subcutaneous fat dominant group. GFR was estimated using the abbreviated Modification of Diet in Renal Disease and quadratic equation. Results: After adjustment for age, mean blood pressure, body mass index, fasting glucose, homeostasis model assessment of the insulin resistance index, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein levels, and mean brachial-ankle pulse wave velocity, the visceral fat dominant group showed significantly lower GFR levels compared with the subcutaneous fat dominant group. The GFR level was negatively correlated with visceral fat areas after adjustment for age. By stepwise multiple regression analysis, age, triglyceride and visceral fat areas independently affected GFR levels. Conclusion: Our study shows that even in apparently healthy women, visceral fat seems to be an important contributor to renal impairment. Further studies on the causality between visceral adiposity and renal function are warranted.

Keywords:
Visceral fat, Fat distribution, Glomerular filtration rate, Renal function
This content is only available via PDF.
© 2009 S. Karger AG, Basel
2009
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.