... vasodilation in a concentration-dependent manner in the isolated rat thoracic aortas. Removal of endothelium or pretreatment of aortic rings with L-NAME, 1 H -[1,2,4]-oxadiazolo-[4,3- a ]-quinoxalin-1-one, and wortmannin significantly inhibited XAT-induced relaxation. In addition, treatment with thapsigargin...

... XE991 antagonizes the vasodilator effect of adipose tissue [ 15,18 ]. We therefore tested this compound on the response to phenylephrine of these mouse carotid arteries in the absence and presence of adipose tissue. The results are seen in Figure 2 . In the absence of phenylephrine, XE991 (10 µ M...

.... Therefore, we investigated the effects and mechanisms of nobiletin on rat isolated mesenteric arteries (MAs). Methods: We examined vasodilation induced by nobiletin on rat isolated MA rings with a tension study, the expression and activity of endothelial nitric oxide synthase (eNOS) with Western blotting...

... in protein and mRNA expression in the rat middle cerebral artery (MCA) and cerebral basilar artery (CBA). Acetylcholine (ACh) induced significant hyperpolarization and vasodilation in endothelium-intact MCA and CBA. Removal of the endothelium abolished these responses. The nitric oxide (NO) synthase...

... dysfunction, characterized by reduced endothelium-dependent vasodilation. The aim of this study was to assess endothelial function in isolated coronary and digital arteries using an ovine model of collagen-induced RA. Methods: Sheep were culled following induction of arthritis, and their endothelial function...

...). Methods: In PGF2α-preconstricted MSVs, bradykinin (BK), sodium nitroprusside (SNP) and S -Nitroso- N -acetylpenicillamine (SNAP) concentration-response curves were generated at intermediate (6 mm Hg) and high (12 mm Hg) pressures. BK-induced vasodilation was examined in the absence and presence of nitric...

... cell Proteinase-activated receptor Rat aorta Vasodilation Oxidative stress Trypsin © 2010 S. Karger AG, Basel 2010 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pial arterioles Vasodilation Vascular endothelium Asphyxia Potassium channels Oxygen radicals R^e"sVeaarscc uh la...

..., instructions or products referred to in the content or advertisements. Proteinase-activated receptor 2 Nitric oxide Hypotension Vasodilation Vascular endothelium ^"V ascular Research Research Paper J Vase Res 1997;34:267-272 Received: July 23, 1996 Accepted after revision: February 18.1997 Kjell...

... to complete vasodilation of the arterioles, because their diameters did not further increase during reactive hyperemia after complete occlusion. ADO (10∼ 4 M) induced an increase of control capillary diameter to 5.5 µm (4.1–6.4 µm; median relative increase: 27%; p < 0.0001), resulting in a decrease...

... ), elastin peptides induced an endothelium-dependent vasodilation. The pretreatment of aortic rings with N-ω-nitro- L -arginine methyl ester (10 –5 M ), an inhibitor of nitric oxide (NO) production, or with indomethacin (10 –5 M ), an inhibitor of cyclooxygenase, prevented elastin peptide-induced...

... of endothelium-derived relaxing factor (EDRF). Hemoglobin (3 and 10 µ M) and methylene blue (10 µ M )both produced marked inhibition of this EDRF-mediated relaxation. In the perfused mesenteric arterial vasculature of the rat, ACh-induced vasodilation was also inhibited by hemoglobin and by methylene blue...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cyclic GMP Guanylate cyclase activation Nitric oxide Nitrogen oxides Endothelium-dependent vasodilation Endothelium...

...Joseph E. Brayden; John M. Quayle; Nicholas B. Standen; Mark T. Nelson Many endogenous and pharmacological vasodilators hyperpolarize vascular smooth muscle and this response appears to be due to an increased conductance to potassium ions. The hyperpolarization may contribute to the mechanism...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endothelium-dependent Vasodilation Cytochrome P-450 inhibitors Metyrapone SKF-525A Blood Vessels 21: 223-230 (1984...

... to adenosine and ATP were significantly antagonised by 8-phenyltheophylline, a potent P 1 purinoceptor antagonist. αβ-Methylene ATP further contracted the high-tone preparation and was again unaffected by removal of the endothelium. These results confirm that endothelial cells can mediate vasodilation...

... distribution of high affinity receptors and/or different states of active vascular tone of the particular preparation. 23 9 2008 Atrial natriuretic factor Cyclic GMP Particulate guanylate cyclase Vasodilation Vasorelaxation Vascular smooth muscle © 1987 S. Karger AG, Basel 1987...

... modulates pulmonary artery tone in both man and cow. Vasoactive intestinal peptide Peptide histidine isoleucine Vasodilation Pulmonary artery 16 06 1986 11 09 1986 23 9 2008 © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

...Robert F. Furchgott; Maria Helena Carvalho; Mohammad T. Khan; Kazuki Matsunaga In the perfused mesenteric arterial vasculature of the rabbit, vasodilation by acetylcholine (ACh) was almost completely blocked after a 15-min perfusion of the vasculature with 0.2% collagenase, an enzyme capable...

... and K+Channel Openers Key Words Vasodilation Antihypertensives Sulfonylureas K+channel openers Vascular smooth muscle KAtp channel Abstract This study in isolated rabbit superior artery (RMA) investigated the interac­ tions between glyburide, a known blocker of vascular ATP-sensitive K+chan­ nels (K.vrp...