...Aaron Gelinne; Lucia Brown; Nga Ling Ko; George Osol; Stephen Brown Background/Aims: Ten-eleven translocation 2 ( Tet2 ), a DNA demethylase enzyme, has been identified as a master epigenetic regulator of vascular smooth muscle cell plasticity. We hypothesized that pregnancy will induce significant...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Aorta Blood vessel Isometric contraction Myography Phenotypic switch Vascular smooth muscle National...

... (NIH) 10.13039/100000002 Arterioles Calcium-activated potassium channel Conducted dilation Endothelium Exercise Gap junctions Microcirculation Resistance arteries Sympathetic nerves Vascular smooth muscle Ascending vasodilation The two principal cellular elements...

... in the regulation of vascular tone. Activation of mitoK ATP channels in cerebral arteries causes vasodilation, with cell-specific contributions from the endothelium, vascular smooth muscles, and nerves. Preexisting chronic conditions, such as insulin resistance and/or diabetes, prevent preconditioning and impair...

...H.T. Syyong; A.W.Y. Chung; C. van Breemen Background/Aims: Vascular smooth muscle in Marfan syndrome, a connective tissue disorder caused by mutations in FBN1 encoding fibrillin-1, is associated with decreased tonic contraction. As Ca 2+ waves are tightly associated with vasoconstriction, we...

... vascular smooth muscle NAD(P)H oxidase, to upregulate vascular Ca V 1.2 protein. Reactive oxygen species Ca V 1.2 Ca 2+ channel Endothelium Vascular smooth muscle National Institutes of Health (NIH) 10.13039/100000002 Angiotensin II is a potent vasoconstrictor known...

...-inflammatory response of vascular smooth muscle cells (VSMC). The aim of the present study was to examine whether reactive oxygen species (ROS) might be involved in this context. The effect of IL-17A on ROS generation was examined using the fluorescent dye 2′7′-dichlorodihydrofluorescein (H 2 DCF) in primary...

..., U46619, endothelin 1, angiotensin II and phorbol 12, 13-dibutyrate (PDBu). In mesenteric vascular smooth muscle cells (VSMCs), PE stimulated increase in Raf-1 phosphorylation which was inhibited by GW5074. Measurement of [Ca 2+ ] i with Fura-2 showed that GW5074-mediated inhibition of PE-induced...

... and tissue perfusion in the cerebral vasculature both in vivo and in vitro, and in many other vascular beds [ 1, 2 ]. The development of myogenic tone is generally characterized by vascular smooth muscle cell depolarization, leading to an increase in intracellular [Ca 2+ ] ([Ca 2+ ] SMC ) and associated...

... in structure and function of tissues and organs, resulting in CV and related disorders in the offspring [ 11, 12 ]. National Institutes of Health (NIH) 10.13039/100000002 Mean arterial blood pressure Endothelium Nitric oxide Fetal programming Pregnancy Vascular smooth muscle...

...David R. Harder; Andrew R. Lange; Debebe Gebremedhin; Eric K. Birks; Richard J. Roman Recent studies from our laboratory have indicated that vascular smooth muscle cells (VSMC) metabolize arachidonic acid via a P4504A-dependent pathway to 20-hydroxyeicosatetraenoic acid (20-HETE...

... of disease states such as hypertension and diabetes mellitus. 19 06 1995 15 12 1995 24 9 2008 Angiotensin II Mesenteric resistance arteries In situ hybridization Gene expression Osteopontin Elastin Vascular smooth muscle Polyploidy Vascular remodeling Hypertension © 1996...

... or maximal response. These results suggest that isoprenaline acts through β-adrenoceptors present on vascular smooth muscle and that estrogen replacement enhances the relaxant responses induced by β-adrenoceptor activation by an endothelium-independent mechanism. 5 07 1995 21 09 1995 24 9...

.... Vascular smooth muscle Stiffness Shortening velocity Muscle mechanics Relaxation Smooth muscle energetics Original Paper J Vase Res 1995;32:313-319 Robert S. Morelanda-b Ronald F. Coburnb Suzanne Moreland Bockus Research Institute, Graduate Hospital, Philadelphia, Pa., Department of Physiology...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vascular smooth muscle Growth Serum Calcium channel antagonist Y a.si'iilar R esearch Research Paper J Vase Res 1997;34:103-108 Received: July...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vascular smooth muscle Transplantation Allograft Autograft Arterial rejection Matthew A. Galumbeck3 Paul H. Ralzh Departments of Plastic...

... Vascular smooth muscle Energetics Creatine Saturation transfer ATP ADP Hypoxia-induced relaxation Research Paper J Vase Res 1995;32:24-30 Joseph F. Clarka Patrick F. Dillonb Department of Biochemistry, University of Oxford, UK; Departments of Physiology and Radiology, Michigan State University...

...Stephanie W. Watts; Cheol Ho Yeum; George Campbell; Clinton Webb Serotonin (5-HT, 5-hydroxytryptamine) is a mitogen in vascular smooth muscle and vascular reactivity to 5-HT is significantly enhanced in hypertension and atherosclerosis. We have tested the hypothesis that tyrosine kinases, enzymes...

... Chetan Goud Stephanie W. Watts R. Clinton Webb Department of Physiology, The University of Michigan. Ann Arbor. Mich., USA Photorelaxation Is Not Attenuated by Inhibition of the Nitric OxidecGMP Pathway Key Words Ultraviolet light Guanylate cyclase Vascular smooth muscle Abstract Photorelaxation...

... junctions Heptanol Nitric oxide Octanol Sucrose Vascular smooth muscle Abstract Studies have provided evidence for the role of gap junctional intercellular communication in syncytial tissue function. This study tested the hypothesis that the vasodilating effects of nitric oxide (NO) rely on gap junctions...