...Susana R. Garcia; Ashley S. Izzard; Anthony M. Heagerty; Stuart J. Bund The aims of this study were to investigate myogenic tone in cannulated coronary arteries from SHR (spontaneously hypertensive rats) and WKY (Wistar-Kyoto rats) at 5 and 20 weeks of age under pressurised no-flow conditions...

...Scott D. Smid; Derek B. Frewin; Catherine L. Wyartt; Richard J. Head Treatment of spontaneously hypertensive rats (SHR) with α-adrenoceptor antagonists failed to alter the development of hypertension in this animal model. However, agents such as captopril (CAP) and losartan (LOS) which interfere...

...M. Mano; S. Jeffreson; R.J. Head We have examined the disposition of catecholamines in cardiac tissue, mesenteric arteries and ganglia from normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP). The norepinephrine (NE...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Smooth muscle cells Polyploidy Spontaneously hypertensive rat...

...R.J. Head There is now compelling evidence indicating that there is a greater sympathetic innervation of blood vessels in the spontaneously hypertensive rat (SHR) when compared with the innervation of corresponding vessels in the normotensive genetic control rat (WKY). In selected vascular beds...

...Richard J. Head Two distinguishing features of the vasculature of the spontaneously hypertensive rat (SHR) are an increased sympathetic innervation and vascular smooth muscle hyperplasia. Evidence supporting the existence of hypernoradrenergic innervation and vascular smooth muscle cell hyperplasia...

...Julie R. Jonsson; Derek B. Frewin; Richard J. Head Morphometric studies conducted on the blood vessels of the spontaneously hypertensive rat have provided evidence that medial hypertrophy is a key characteristic of the vascular change which occurs in hypertension. In the present study, we...

... (0.05% Na + ). Angiotensin was seen to enhance the field-stimulation (480 pulses, 2 Hz, 1 ms duration, supramaximal voltage) induced release of 3 H-norepinephrine from vessels obtained from Sprague-Dawley, Wistar, Wistar-Kyoto (WKY) and the spontaneously hypertensive rats (SHR) maintained on a normal...

...Suzanne M. Dyer; David Taylor; Sotiria Bexis; Neil J. Hime; Derek B. Frewin; Richard J. Head Aortic ring preparations from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were treated with N ω -nitro-L-arginine (NOLA, 10 –4 M ) . This produced a sustained contraction...

... in noradrenergic transmission at the vascular neuroeffector junction. Norepinephrine release Vascular neuroeffector junction Hypertension Spontaneously hypertensive rat Caudal artery Mesenteric artery Portal vein DOCA salt hypertension Renal hypertension © 1987 S. Karger AG, Basel 1987 Copyright...

...Masanobu Urabe; Che Su; Tony J.-F. Lee The effects of angiotensin I (AI) and angiotensin II (AII) on ring segments of femoral arteries from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied. AI and AII elicited significantly greater direct contractile...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Spontaneously hypertensive rat Norepinephrine sensitivity Vascular smooth muscle...

...Michael J. Antonaccio; Thomas Cavaliere; Donald Cote Heart rate, systolic blood pressure and responses of spontaneously hypertensive rats (SHR) to guanethidine, timolol, minoxidil and phentolamine were monitored at 2, 6 and 12 months of age. All antihypertensive agents produced significant...

...M.J. Mulvany; B. Ljung; M. Stoltze; A. Kjellstedt In perfusion experiments, previous investigations have shown an increased responsiveness of isolated vascular beds from spontaneously hypertensive rats (SHRs) compared with Wistar-Kyoto controls (WKYs). The results have suggested...

... the apparent K a value (concentration required for half maximal stimulation) for Gpp(NH)p stimulation. In a comparative study of adenylate cyclase activity between spontaneously hypertensive rats (SHR) and Kyoto Wistar normotensive rats (WKY), using 0.6 M KC1 washed membranes from aorta and caudal artery...

...M.J. Mulvany This review summarizes some of the evidence pointing to the existence of vascular abnormalities in the spontaneously hypertensive rat (SHR) and the extent to which such abnormalities could be responsible for the elevated blood pressure in this animal. Compared with its genetic...

... t U SA Key Words. Spontaneously hypertensive rat Adrenergic function Resistance arteries Potassium depolarization Norepinephrine 6-Hydroxydopamine Phentolamine Abstract. We characterized the function of adrenergic nerve varicosities in mesenteric resistance arteries from spontaneously...

...Jiann-Wu Wei; Ronald A. Janis; Edwin E. Daniel The effect of Sr++, Ba++ and Mn++ on calcium uptake by a plasma membrane-enriched fraction from mesenteric arteries of spontaneously hypertensive rats (SHR) was studied to determine what alterations in divalent cation interactions are associated...

...S. Ramanathan; Shoji Shibata The vascular smooth muscle (aorta, portal vein and renal arteries) from spontaneously hypertensive rats (SHR) contained a lower level of cyclic adenosine-3’5’-monophosphate (cyclic AMP). Similar differences were observed in young SHR that had not yet developed...

.... The differences seen in cyclic AMP and protein kinase levels in the intact aortas are also seen in the aortic smooth muscle cells in culture. 6 10 1975 23 04 1976 18 9 2008 Blood Vessels 13: 361-373 (1976) Cyclic AMP and Protein Kinase in the Spontaneously Hypertensive Rat Aorta and Tissue...