..., instructions or products referred to in the content or advertisements. 2024 Coronary artery bypass graft Saphenous vein Endothelial cells Smooth muscle cell Neointimal hyperplasia occurs when vascular smooth muscle cells (SMCs) proliferate and migrate toward the vessel lumen occluding blood...

... aortic dissections in mice. Here, we provide insight on a modified aortic dissection model in rats. The effect of smooth muscle cell (SMC) relaxation with vasodilators is studied in this model. Methods: Forty Sprague-Dawley rats were divided in 4 groups: control, isosorbide dinitrate (ISDN, 30 mg/kg/day...

...Jessica Davis-Knowlton; Jacqueline E. Turner; Anne Harrington; Lucy Liaw Introduction: We previously identified Notch2 in smooth muscle cells (SMC) in human atherosclerosis and found that signaling via Notch2 suppressed human SMC proliferation. Thus, we tested whether loss of Notch2 in SMC would...

.... Aortic perfusion Ex vivo mineralization Smooth muscle cell Vascular calcification Calcification of the vascular wall remains a major cause of morbidity and mortality in elderly patients as well as in patients with a high cardiovascular risk, e.g., those with end-stage renal disease [ 1...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Vascular tissue engineering Heparin Poly-ε-caprolactone Endothelium Smooth muscle cell Cardiovascular disease has become one of the many diseases that threaten human life owing to its high...

... conductance Ca 2+ -activated K + (BK) channel function in coronary smooth muscle cells (SMCs) of streptozotocin-induced diabetic rats. Methods: The effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on coronary BK channel open probabilities were determined using the patch clamp technique...

... and PBS. All the other chemicals were dissolved in deionized water. Subarachnoid hemorrhage Vasospasm Vascular remodeling Biomechanics Smooth muscle cell Transglutaminase The mortality rate associated with subarachnoid hemorrhage (SAH) is currently 25-30%, with about 50% of remaining...

...) load. Methods: We tested the interaction of 10 n M aldosterone, 15 m M NaCl and 1 µ M ouabain using rat aorta smooth muscle cells (A10) with respect to the following parameters: necrosis, apoptosis, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase activity, glutathione (GSH...

...Yuefeng Tang; Xuehui Yang; Robert E. Friesel; Calvin P.H. Vary; Lucy Liaw Background: Transforming growth factor-β (TGF-β) plays an important role in vascular homeostasis through effects on vascular smooth muscle cells (SMC). Fine-tuning of TGF-β signaling occurs at the level of ALK receptors...

... determinants for vascular remodeling. The cytoskeletal elements and actin re-organization during remodeling are discussed, as well as the re-lengthening of smooth muscle cells during prolonged constriction. We then consider tone as major causal factors in remodeling and discuss the role of vessel wall...

..., migration, and synthesis of extracellular matrix, which results in the formation of a neointima, vascular remodeling, and restenosis [ 2 ]. Neointimal smooth muscle cells (SMC) after vascular injury may not originate from media, as previously believed, but represent a progeny of circulating precursors...

...Frits N.G. Doornekamp; Cornelius Borst; Mark J. Post Interventional-injury-induced intimal hyperplasia involves smooth muscle cell proliferation that may be limited by endothelial cell coverage. We hypothesized that endothelial cell coverage modulates intimal hyperplasia. Therefore rabbit carotid...

... significantly more PDGF produced by the distal compared to proximal aorta at 77 ± 10 versus 14 ± 6 pg/cm 2 /72 h (p < 0.05). Endothelial cells (EC) and smooth muscle cells (SMC), isolated from analogous aortic sites, were grown in tissue culture and the conditioned medium was assayed for PDGF. EC in vitro...

...Lieselotte van Erven; Mark J. Post; Evelyn Velema; Cornelius Borst Angioplasty inflicts damage to the arterial wall. We studied whether augmented medial smooth muscle cell necrosis leads to augmented intimal hyperplasia and thus aggravates restenosis. Sixty-three normal femoral arteries of New...

... to in the content or advertisements. Arterial injury Heparin Heparan sulfate proteoglycan Smooth muscle cell Matrix proteins Research Paper J Vase Res 1993:30:161-168 Seiiaro Mutoh Monika M. Clowes Alexander W. Clowes Department of Surgery, School of Medicine, University of Washington, Seattle, Wash...

...Paul D. Bonin; Jai Pal Singh; Ronald B. Gammill; Laurence A. Erickson Medial smooth muscle cell migration and neointimal proliferation are primary contributors to the delayed restenosis that occurs after percutaneous transluminal coronary angioplasty. In this study, we describe...

...P.A. Underwood; S.M. Mitchell; J.M. Whitelock The proliferation of vascular smooth muscle cells (VSMC) plays a significant part in both the developing atherosclerotic lesion and in restenosis. Heparin has been widely reported to inhibit the growth of VSMC in culture and intimal VSMC in some animal...

... angionecrosis without pressor activity was partially purified. 18 9 2008 Angionecrosis Vascular permeability Renal lysosome Cerebral artery Pancreas Smooth muscle cell © 1978 S. Karger AG, Basel 1978 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... MCP-1 Smooth muscle cell Transplantation Arteriopathy is the leading cause of long-term morbidity and mortality following heart transplantation [ 1 ]. Arteriopathy can precipitate myocardial infarctions, graft failure and death. Within 5 years of transplantation, 50% of cardiac transplant...

... labeling indicates that neo-intimal formation was mainly due to proliferation and migration of smooth muscle cells. Smooth muscle cell proliferation, assessed by MIB-1 staining, was maximal at day 14 after stent insertion. Human mammary artery organ culture thus provides valuable information...