.... 2024 Homocysteine Endothelium Vascular disease Shear stress There is evidence that the association between homocysteine and cardiovascular disease is causal [ 1 ]. Human vascular endothelial cells are damaged by homocysteine concentrations and the damage is thought to be mediated by H...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 Atrial fibrillation Flow-mediated dilatation Shear stress Warfarin Apixaban Atrial fibrillation (AF...

..., H1-calponin, Ift88, and p-smad3 in ECs. Results: The expression of αSMA, SM22α, and Cx43 was significantly increased, and CD31 was markedly decreased in ECs treated with laminar shear stress at 5 dyn/cm 2 . The Cx43 cDNA transfection could induce the expression of SM22α or H1-calponin and attenuate...

...Therese Ruane-O’Hora; Farouk Markos The aim of this study was to investigate whether platelets contribute to shear stress and vascular conductance in the iliac vascular bed in vivo. Flow-mediated dilation of pig iliac was induced by downstream injection of acetylcholine (50 μg), and separately...

.... In the last 2 decades, the development and deployment of innovative genetic manipulation techniques greatly facilitated the application of zebrafish as an animal model for studying basic biology and diseases. Hemodynamic shear stress is intimately involved in vascular development and homeostasis. The critical...

.... Endothelial nitric oxide synthase Shear stress Vascular remodeling Circadian clock gene Endothelial function Shear stress The force and composition of circulating blood is an important stimulus to the vasculature, affecting endothelial signals that are relayed to smooth muscle to cause functional...

..., instructions or products referred to in the content or advertisements. Endothelial cells Resistance vessels Ca 2+ Shear stress Endothelial nitric oxide synthase subcellular location National Institutes of Health (NIH) 10.13039/100000002 Nitric oxide (NO) is a ubiquitous...

...Annette Ploppa; Miriam Kampmann; Tanja Johannes; Helene A. Haeberle; Boris Nohé Background/Aims: The study examined the interdependent effects of shear stress and different leukocyte subpopulations on endothelial cell activation and cell interactions during low flow and reperfusion. Methods: Human...

...Theres Hennig; Christina Mogensen; Julian Kirsch; Ulrich Pohl; Torsten Gloe Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes. Based on previous studies demonstrating integrin-mediated release...

... exposed for 24 h to unidirectional (0.3 ± 0.1 or 6 ± 3 dynes/cm 2 ) shear stress oriented along flow direction, while those exposed to bidirectional shear stress (0.3 ± 3 dynes/cm 2 ) or static conditions had random orientation. Under bidirectional flow, tissue factor (TF) activity and mRNA expression...

... to inflammatory stimuli, migrate and grow new blood vessels, lay down extracellular matrix, and take up low-density lipoproteins. We also examined the ESC-EC ability to upregulate NO in response to shear stress and downregulate NO in response to pro-inflammatory TNF-α activation. Functional responses of ESC-EC...

... umbilical veins (HUVEC) or arteries (HUAEC) or from human coronary arteries (HCAEC) after ‘static’ culture or exposure to shear stress (2 Pa for 24 h) and treatment with tumour necrosis factor-α (TNF-α) or interleukin-1β (IL-1β). Results: Static cultures of each type of EC recruited flowing neutrophils...

...Jaume Padilla; Blair D. Johnson; Sean C. Newcomer; Daniel P. Wilhite; Timothy D. Mickleborough; Alyce D. Fly; Kieren J. Mather; Janet P. Wallace Background/Aims: Although normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress (FMD:shear stress ratio) has been...

... studies have established that shear stress is an important mechanical factor that regulates endothelial structure, function and growth. Numerous investigations, primarily in the systemic circulation, have focused on physiological shear stress (10–25 dyn/cm 2 ) and relatively low shear stress (<5 dyn/cm...

... , with an overall effect of limited dilation. These mediators are likely to have important roles in the multiple feedback regulation of wall shear stress in venules during changes in blood flow velocity and/or viscosity. Small veins and venules have an important role in determining the amount of blood flow...

... shear stress (FSS). We studied the role of known potent angiogenic growth factors (separately or in combination) in arteriogenesis by determining their expression in FSS-stimulated collaterals and close-to-collateral infusion of growth factor peptides in a rabbit model of femoral artery occlusion...

... at the plateau of constriction led to dilations that were also weaker in SHR compared to WKY vessels: 27 ± 6 vs. 61 ± 3, p < 0.001, when expressed as percentage of maximal initial constrictions. The maximal dilation induced by flow in SHR arteries was obtained for a greater value of shear stress compared...

... permits the chronic exposure of cultured EC and VSMC to physiological shear stresses, cocultures were exposed to stepwise increases in flow up to (1) 2 ml/min (low flow: 0.5 dyn/cm 2 ) or (2) 44 ml/min (high flow: 15 dyn/cm 2 ) and maintained for 72 h before SMC and EC were harvested separately...

... suggest that the flow-sensitive mechanism may be similar in the two vessels. 26 11 1993 29 06 1994 24 9 2008 Shear stress Flow-induced contraction Blood vessels Contraction Extracellular sodium 45 Ca 2+ unidirectional influx and net uptake © 1995 S. Karger AG, Basel...

... to cation channels in the plasma membrane by a pathway which appears to involve activation of both tyrosine and serine/threonine kinases since this portion of the Ca 2+ response is attenuated by both tyrosine kinase inhibitors and serine phosphatase inhibitors. In response to fluid shear stress...