...Lars K. Markvardsen; Lene D. Sønderskov; Christine Wandall-Frostholm; Estéfano Pinilla; Judit Prat-Duran; Mathilde Aalling; Susie Mogensen; Charlotte U. Andersen; Ulf Simonsen Introduction: Pulmonary hypertension is characterized by vasoconstriction and remodeling of pulmonary arteries, leading...

...Jie Fu; Peiyuan Bai; Yiwei Chen; Tingting Yu; Fen Li Background and Aims: Pulmonary hypertension (PH) is a chronic progressing vascular disease characterized by pulmonary arteriole remodeling and loss of pulmonary microvasculature. The aim of this study was to investigate a potential role...

...Siqin Zhaorigetu; Henry Bair; Jonathan Lu; Di Jin; Scott D. Olson; Matthew T. Harting Although it is well known that nitrofen induces congenital diaphragmatic hernia (CDH), including CDH-associated lung hypoplasia and pulmonary hypertension (PH) in rodents, the mechanism of pathogenesis remains...

...Gongyong Peng; Xing Wen; Yu Shi; Yongliang Jiang; Guoping Hu; Yumin Zhou; Pixin Ran Pulmonary endothelial dysfunction plays an integral role in the pathogenesis and development of pulmonary hypertension. It is difficult and inconvenient to obtain pulmonary arterial endothelial cells (PAECs) from...

.... It is noteworthy that severe alterations including concentric neointimal thickening, abnormal endothelial proliferation, plexiform lesions and vascular occlusion with fibrin thrombi were observed in the combined pulmonary hypertension model when exposed to a long period of hypoxia. The present data indicate...

...Anita Umesh; Omkar Paudel; Yuan-Ning Cao; Allen C. Myers; James S.K. Sham Background: Pulmonary hypertension is associated with vascular remodeling and increased extracellular matrix (ECM) deposition. While the contribution of ECM in vascular remodeling is well documented, the roles played...

... to in the content or advertisements. ET B receptor Knockout Endothelin Pulmonary hypertension Pulmonary arterial hypertension (PAH) is a progressive condition involving small pulmonary arteries (PAs) characterised by a sustained increase in pulmonary vascular resistance and vascular remodelling...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pulmonary hypertension Shear stress Nitric oxide Endothelin Vascular tone Vascular remodeling Alterations in pulmonary blood flow are thought to be a critical...

... Bronchial vessels Radioimmunoassay Pulmonary hypertension Angiogenesis Neovascularizat ion Abstract Postobstructive pulmonary vasculopathy (POPV) is produced by chronic liga­ tion of one pulmonary artery and results in bronchial collateral vessel prolifer­ ation and pulmonary arterial abnormalities...

...James C. McKenzie; John Clancy, Jr.; Robert M. Klein The results of this study indicate that both cell proliferation and increased synthesis of extracellular matrix protein contribute to hypertrophy of the rat pulmonary trunk during the early development of hypoxia-induced pulmonary hypertension...

..., and hyperresponsive to intra-arterial prostaglandin F 2 α . After exposing rats to simulated high altitude (4-6 weeks at 4,270 m) to induce hypoxic pulmonary hypertension, SHRhad a higher right ventricular systolic pressure, a greater degree of right ventricular hypertrophy, and more pulmonary artery medial...

...James C. McKenzie; Robert M. Klein The purpose of this study was to determine the temporal alterations in protein synthesis and accumulation in the rat pulmonary trunk during the early development of hypoxia-induced pulmonary hypertension and to correlate these results with the pattern...

... vascular tone in rat lungs of control and monocrotaline (MCT)-induced pulmonary hypertension. Inhibition of EDHF with a combination of K Ca blockers, charybdotoxin (50 n M ) plus apamin (50 n M ), increased baseline vascular tone in MCT-induced hypertensive lungs. Thapsigargin (TG; 100 n M ), an inhibitor...

... was less in monocrotaline-treated rats compared with controls. Y-27632 concentration dependently relaxed ring segments of pulmonary artery pre-contracted with noradrenaline (10 –5 M ). The pIC 50 values were 6.46 ± 0.09 (n = 5) 5.81 ± 0.06 (n = 5) in control and pulmonary hypertensive rings, respectively...

...Eric A.G. Demoncheaux; Tim W. Higenbottam; David G. Kiely; Ju-Ming Wong; Simon Wharton; Richard Varcoe; Tom Siddons; Alan C. Spivey; Keith Hall; Andy P. Gize Impaired pulmonary release of nitric oxide (NO) is one of the characteristic phenotypic changes of vascular cells in pulmonary hypertension...

...William H. Stotz; Dechun Li; Roger A. Johns The histopathology of chronic pulmonary hypertension includes microvascular proliferation and neointimal formation. Nitric oxide (NO) has been implicated in the regulation of these mechanisms, but how NO controls microvascular proliferation and its effect...

...Shiro Kato; Izumi Kishiro; Hiroyuki Sugimura; Suguru Machida; Daisuke Fuse; Noboru Kaneko The role of leukocytes (WBCs) and platelets (PLTs) in the pulmonary circulation may be important in the development of monocrotaline (MCT)-induced pulmonary hypertension in rats. We investigated...