...Therese Ruane-O’Hora; Farouk Markos The aim of this study was to investigate whether platelets contribute to shear stress and vascular conductance in the iliac vascular bed in vivo. Flow-mediated dilation of pig iliac was induced by downstream injection of acetylcholine (50 μg), and separately...

... of atrial fibrillation. Observational data hypothesized a cardioprotective effect. In an in vitro endothelial cell-platelet model, we evaluated the molecular atheroprotective effects of dronedarone. Methods: Following a 24-h incubation of human umbilical vein endothelial cells (HUVECs) with dronedarone...

...Vasileios G. Chantzichristos; Fani Gkrozou; Konstantinos Stellos; Minas E. Paschopoulos; Alexandros D. Tselepis Background/Aims: Platelets affect endothelial progenitor cell (EPC) functionality, inducing their differentiation into mature endothelial cells. However, it remains to be established...

...Wenhui Qian; Li Tao; Yingyu Wang; Feng Zhang; Mengqiu Li; Shile Huang; Aiyun Wang; Wenxing Chen; Zhiqiang Yue; Lei Chen; Yuping Liu; Chenhu Huang; Lei Zhang; Yao Li; Yin Lu Activated platelets have been recognized as an accessory character in the cascade of tumor hematogenous metastasis...

... norepinephrine levels, α 2 -adrenoceptor binding or platelets of β 2 -adrenoceptor binding of lymphocytes. The major postjunctional α-adrenoceptors in this artery are of the α 1 type. The data suggest that differences in potency of α-adrenoceptor agonists in relation to blood pressure may be due to differences...

...Azza Agha; Hartmut Schlüter; Stefanie König; Klaus Biel; Martin Tepel; Walter Zidek Platelet homogenates from 200 ml blood of essential hypertensives (n = 28) and normotensives (n = 13) were deproteinized and separated by gel chromatography. The fractions obtained were then tested for vasopressor...

... of the vascular smooth muscle of the SH rats to vasoconstrictor substances liberated from platelets at the site of injury. © 1977 S. Karger AG, Basel 1977 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

...Constantin von zur Muhlen; Karlheinz Peter; Ziad A. Ali; Jürgen E. Schneider; Martina A. McAteer; Stefan Neubauer; Keith M. Channon; Christoph Bode; Robin P. Choudhury Ruptured atherosclerotic plaques, lined with activated platelets, constitute an attractive target for magnetic resonance imaging...

...Rainer Kiefmann; Kai Heckel; Sonja Schenkat; Martina Dörger; Alwin Eduard Goetz Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia. The aims of the present study were to localize platelet...

... these insights. Atherothrombosis Cyclooxygenase Platelets NSAID Cyclooxygenase-2 The spectacular, worldwide withdrawal of Vioxx (rofecoxib) from the market, followed by a similar warning about Celebrex (celecoxib), has initiated legal and commercial sequelae and has also induced great uncertainty...

...Matthias S. Göpfert; Frank Siedler; Wolfgang Siess; Alois Sellmayer Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases. In order to study platelet-activating components of oxidized...

...M.E. Eichhorn; L. Ney; S. Massberg; A.E. Goetz Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet. The aim of this study was to develop a model enabling...

...Shiro Kato; Izumi Kishiro; Hiroyuki Sugimura; Suguru Machida; Daisuke Fuse; Noboru Kaneko The role of leukocytes (WBCs) and platelets (PLTs) in the pulmonary circulation may be important in the development of monocrotaline (MCT)-induced pulmonary hypertension in rats. We investigated...

...Jean-Guy Bienvenu; Jean-François Tanguay; Patrick Chauvet; Yahye Merhi Platelet and neutrophil interactions with injured vascular wall may contribute to restenosis. Their importance was mainly examined following balloon injury of intact arteries. However, dilation of diseased arteries is clinically...