... to in the content or advertisements. 2025 Oxidative balance score Mortality Hypertension Oxidative stress National health and nutrition examination survey Hypertension (HTN) affects about 1.28 billion individuals worldwide and constitutes a significant contributor to both all-cause...

..., is vulnerable to oxidative stress, leading to endothelial dysfunction, which strongly correlates with cardiovascular disease (CVD). This study investigates the protective effects of rivaroxaban, a factor X inhibitor, on the glycocalyx under oxidative stress condition. Methods: We examined the impact...

...Nataša Kozina; Ivana Jukić; Zrinka Mihaljević; Anita Matić; Marina Dobrivojević Radmilović; Anja Barić; Ines Drenjančević Introduction: It is well documented that high-salt (HS) diet increases systemic and vascular oxidative stress in various animal models and in humans, leading to impairment...

... High glucose Diabetes Tetrahydroxystilbene glucoside Endothelial cells Apoptosis Oxidative stress Accumulating evidences indicate that diabetes mellitus can cause a wide variety of vascular complications and cardiovascular dysfunction [ 1‒3 ]. Endothelial dysfunction is thought...

... and CHD9 reversed the inhibitory effect of miR-22-3p mimics on cell proliferation, migration, and oxidative stress in ASMCs. Finally, miR-22-3p suppressed vascular remodeling and oxidative stress in vivo. Overall, miR-22-3p regulated ASMC phenotype switch by targeting CHD9. This new discovery provides...

...Rodrigo O. Marañón; Claudio M. Joo Turoni; María Peral de Bruno Background: Oxidative stress plays an essential role in the vascular tone in hypertension; however, the mechanisms remain unclear. Aim: This study aimed to determine the antioxidant effect of tempol and vitamin C (Vit-C) on the basal...

...Sangwon Yoon; Eunjo Lee; Mina Kim; InKyeom Kim Introduction: Although both glucose and fructose are hexoses, their catabolism is quite different: the catabolism of fructose is initiated by ketohexokinase and is not regulated by negative feedback, which results in oxidative stress. Objective: We...

...Min Young Ahn; Sun Ah Ham; Taesik Yoo; Won Jin Lee; Jung Seok Hwang; Kyung Shin Paek; Dae-Seog Lim; Sung Gu Han; Chi-Ho Lee; Han Geuk Seo Thrombospondin-1 (TSP-1) is implicated in vascular diseases associated with oxidative stress, such as abdominal aortic aneurysms, ischemia-reperfusion injury...

..., -8, -9 activities were also measured. Results: We found that Ang II treatment increased the generation of ROS, enhanced MPTP opening and cytochrome c release, activated caspase-3/9, and consequently induced HUVEC apoptosis. EGCG treatment-suppressed Ang II induces the oxidative stress of HUVECs...

... as the extent of DNA damage (phospho-p53), were performed. Oxidative stress followed upon the termination of malondialdehyde, reduced glutathione, thiol group, and superoxide dismutase plasma levels. Inflammatory changes were measured by the determination of serum tumor necrosis factor-α and interleukin-1...

...Maria Giovanna Scioli; Alessandra Bielli; Sara Agostinelli; Chiara Tarquini; Gaetano Arcuri; Amedeo Ferlosio; Gaetana Costanza; Elena Doldo; Augusto Orlandi Aims: Oxidative stress plays a pivotal role in the impaired endothelial function occurring in vascular diseases. Antioxidant strategies induce...

..., there is evidence showing that oxidative stress can induce osteogenic gene expression leading to calcification of VSMC [ 11,12,13,14 ]. Some studies have shown that the activity of NADPH oxidase, a key enzyme in ROS production, is implicated in the expression of osteoblastic gene markers [ 13,14 ]. It has also been...

... (eNOS) expression, e.g. in response to an increased superoxide production in endothelial cells [ 6 ]. Uncoupling of eNOS [ 7 ] results in the production of superoxide which, in turn, reacts rapidly with NO to produce peroxynitrite [ 8 ]. While causing oxidative stress along with other reactive oxygen...

...Marie Briet; Ernesto L. Schiffrin Aldosterone exerts direct effects on the vascular system by inducing oxidative stress, inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone exerts its effects through genomic and nongenomic pathways in a mineralocorticoid...

..., in the presence of ADMA, we investigated the dilator effect of an NO donor and increases in flow and aimed to elucidate the underlying mechanisms, including the role of oxidative stress, which is known to reduce the bioavailability of NO. Methods and Results: In isolated rat gracilis skeletal muscle arterioles...

... with superoxide dismutase or NADPH inhibitor apocynin restored the enhanced contractile response to phenylephrine to WT levels. β 2 KO aortas exhibited oxidative stress detected by enhanced dihydroethidium fluorescence, which was normalized by apocynin. Protein expression of eNOS was reduced, while p47 phox...

... ) and placed in an FB12 luminometer. After a 2-min dark adaptation period, measurement of emitted light was obtained every 30 s and averaged over a 5-min period. Restenosis NADPH oxidases Oxidative stress Antioxidants National Institutes of Health (NIH) 10.13039/100000002 SMCs...

... oxidative stress and dysfunction. In the present study, we sought to determine whether vascular dysfunction and oxidative stress strictly depend on insulin deficiency. Methods: The effects of insulin (2.5 U/day s.c., 2 weeks) therapy on vascular disorders in STZ-induced (60 mg/kg i.v., 8 weeks) diabetes...

.... Conclusion: Although ouabain treatment induced hypertension in all groups, a larger noradrenaline induced contraction was observed over 20 weeks of treatment. This vascular dysfunction was related to COX-2-derived prostanoids and oxidative stress, increased pro- inflammatory cytokines and reduced...

...Murasaki Aman; Mayumi Hirano; Hideo Kanaide; Katsuya Hirano Background/Aims: The effects of oxidative stress on the vascular responsiveness to the agonists of proteinase-activated receptors (PARs) were investigated. Methods: Serum-free incubation was utilized to impose oxidative stress to isolated...