...George Wyse This cross-sectional study examined responses of the isolated cystic artery to 3 α-adrenoceptor agonists and the effects of 2 antagonists in relation to subjects’ blood pressures. Potency of the 3 amines studied was: α-methylnorepinephrine > norepinephrine > phenylephrine...

...Susan B. Jones; Yu Liu; Allan W. Jones Supersensitivity of vascular smooth muscle to catecholamines in aldosterone-salt hypertensive rats appears to reside beyond the α 1 -adrenoceptor. The objective of this study was to assess the norepinephrine-stimulated production of arachidonic acid...

... measurement obtained in vivo. The purpose of the present study was to determine the effects of norepinephrine (NE) on the coronary microcirculation using direct in vitro approaches. Porcine coronary microvessels (80-200 µm in diameter) were pressurized in isolated organ chambers. Diameters were measured using...

...M. Mano; S. Jeffreson; R.J. Head We have examined the disposition of catecholamines in cardiac tissue, mesenteric arteries and ganglia from normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP). The norepinephrine (NE...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Norepinephrine Nerve growth factor 3-Methylhistidine Hypernoradrenergic innervation Hyperplasia Vascular smooth muscle cell Blood pressure...

...P.H. Carpentier Vasomotion is a potential target for drugs in vascular diseases. In this work, the effects on arteriolar vasomotion of norepinephrine, phentolamine and the vasoactive drug buflomedil were assessed in the hamster skinfold preparation. Results show the strong vaso-kinetic properties...

...Raghu G. Nath; Thomas McCalden Ring segments of the rabbit ear artery were studied in the normal configuration (where drugs entered the media mainly through the adventitia) and in the everted configuration (where drugs entered mainly through the intima). Norepinephrine (NE) produced a faster...

... lengths. The decrease in mean cell length of dispersed cells exposed to serotonin, acetylcholine, and ergonovine maleate was 21.0, 23.0 and 25.5%, respectively (p < 0.05). No significant decrease in cell length was obtained with norepinephrine. The ultrastructure of the relaxed cells seemed...

... in isolated vascular tissue have been minimally successful at best. The present study reports that bovine PTH-(1–34) can relax isolated rat tail artery helical strips precontracted by either arginine vasopressin, depolarizing concentrations of potassium chloride, or norepinephrine. The phenomenon occurs...

...Paulie J. Silin; Judith A. Strulowitz; Michael S. Wolin; Francis L. Belloni We tested the hypothesis that the endothelium-dependent relaxation of rabbit thoracic aorta in vitro is mediated by reduced metabolites of oxygen. Helical vascular strips were contracted with either norepinephrine...

...D.A.S. Parker; I.S. de la Lande; J.A. Thompson; I. Parker The spontaneous and stimulation-induced (SI) effluxes of 3 H-norepinephrine ( 3 H-NE) and its metabolites from the intimal and adventitial surfaces of perfused segments of rabbit ear arteries were determined; vessels were previously...

... (WKY). We noted differences between the norepinephrine (NE) contents of individual tissues from SHR and WKY rats and have used two different analytical procedures for the measurement of NE to confirm these differences. Comparisons between tissue contents of NE in SHR and WKY rats indicated a greater...

...John C. Vitullo; Ross G. Gerrity; Philip A. Khairallah Cross-sections of rat mesenteric vessels were examined histologically after short-term perfusions of angiotensin II (AII), norepinephrine (NE), 5-hydroxytryptamine (5-HT), and histamine. Mesenteric veins (300–400 µm) and muscular venules (50...

... aortas of trout were suspended for isometric force measurements. Acetylcholine and the calcium ionophore A23187 initiated concentration-dependent relaxations in aortas from cayman and bullfrogs contracted with norepinephrine. These relaxations were not affected by meclofenamate, were reversed...

... that mesenteric preparations from SHR rats responded more forcefully to intraluminally administered norepinephrine and potassium, regardless of whether the intestine was absent or present. Similarly, the responses of mesenteric preparations to electrical nerve stimulation were greater in preparations from SHR...

... fluxes of Rb and K were equivalent in rat aorta in the absence of endothelium. The ouabain-sensitive (active) uptake of 86 Rb and 42 K was similar. However, the basal 86 Rb efflux was only 80% of the 42 K efflux. Norepinephrine and KCl depolarization stimulated 86 Rb and 42 K effluxes via a calcium...

... pressure significantly reduced high (50, 70 and 125 m M ) potassium-induced contractions, but not drug (serotonin, norepinephrine, histamine) induced contractions. The intraluminal surface of the MCA was significantly more sensitive to serotonin than the extraluminal surface. The above contractile...

... Muscle Sensitivity A Minireview1 William W. Fleming Department of Pharmacology and Toxicology. West Virginia University Medical Center, Morgantown, W.Va., USA Key Words. Supersensitivity Membrane potential Smooth muscle Reserpine Norepinephrine Histamine Potassium Abstract. A review...

...John A. Bevan; Ismail Laher; Reed Rowan Norepinephrine concentrations in excess of 10 –4 M are achieved at the post-junctional membrane of the adrenergic synaptic cleft in resistance arteries at least for short periods of time. These concentrations are greater than the threshold of low affinity non...

...David P. Westfall; Khaled Sedaa; Richard A. Bjur Electrical field stimulation of the rat caudal artery (0.5-ms pulses at 8 Hz for 3 min) results in the release of norepinephrine (quantified by HPLC-electrochemical detection) and adenyl purines including ATP, ADP and AMP (quantified by HPLC...