...Vinicius P. Garcia; Kelly A. Stockelman; Ma’ayan V. Levy; Hannah K. Fandl; Anabel Goulding; Jamie G. Hijmans; Samuel T. Ruzzene; Auburn R. Berry; Jared J. Greiner; Christopher A. DeSouza Introduction: The aims of this study were to determine (1) whether endothelial nitric oxide synthase (eNOS...

... dysfunction in vivo. Aortic GTPCH I expression and serum nitric oxide (NO) release were measured in young and aged mice. Aortic rings from young and aged wild-type (WT) mice and aged Tg-GCH mice were suspended for isometric tension recording. A hind limb ischemia model was used to measure blood flow recovery...

... arteries responded to all 3 agents ( p < 0.05). While maximal responses to acetylcholine (ACh) were similar between the venous and arterial segments, the dose required to achieve this value was lower ( p < 0.05) in the artery versus vein. Nitric oxide synthase inhibition attenuated ( p < 0.05...

...Xing Wei; Linbo Guan; Ping Fan; Xinghui Liu; Rui Liu; Yu Liu; Huai Bai Electric fields (EFs) promote angiogenesis in vitro and in vivo. These results indicate the feasibility of the application of EFs to modulate angiogenesis. Nitric oxide (NO) derived from endothelial nitric oxide synthase (eNOS...

... of the coronary arteries, i.e., coronary heart disease. Nitric oxide (NO) is synthesised from L-arginine in endothelial cells by the constitutive calcium-calmodulin-dependent enzyme, nitric oxide synthase (NOS), which mediates endothelium-dependent vasodilatation. Endothelial nitric oxide synthase (eNOS...

...: 22 mM). Endothelial senescence was investigated by assessing senescence-associated-β-galactosidase (SA-β-gal), p53, and telomere length. Endothelial function and atherosclerosis were examined by nitric oxide-related-products (NOx: NO 2 – and NO 3 – ), O 2 – , endothelial NO synthase (eNOS), NADPH...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Balloon injury Nitric oxide Redox state Soluble guanylate cyclase Vascular reactivity Soluble guanylate cyclase (sGC), an acceptor for the biological messenger nitric oxide (NO), has been...

...Claudio Molinari; Vera Morsanuto; Simona Polli; Francesca Uberti This work demonstrates the cooperative effect of Q10, vitamin D 3, and L -arginine on both cardiac and endothelial cells. The effects of Q10, L -arginine, and vitamin D 3 alone or combined on cell viability, nitric oxide, and reactive...

... cells and their supernatants on washed platelet aggregation was studied. The effect of OECs and their supernatant on the adenosine diphosphate (ADP)-induced magnitude of platelet integrin receptor α IIb β 3 activation and on P-selectin membrane expression was investigated. The levels of nitric oxide...

... Low-frequency oscillations Spectral analysis Nitric oxide Endothelium-derived hyperpolarizing factor Prostaglandins Control of the blood flow in the peripheral tissues is crucial to maintaining the complex functions of body organs, requiring appropriate modulation of blood supply...

...Louis Kolb; Diego Orbegozo; Jacques Creteur; Jean-Charles Preiser; Jean-Louis Vincent; Daniel De Backer Nitric oxide (NO) plays an important role in controlling microcirculatory function, but the effects of exogenous administration of nitrate (NO 3 - ) on the microcirculation have not been well...

... were studied. Functional responses to noradrenaline (NA), potassium chloride and endothelium-dependent and independent relaxations were investigated in vitro using acetylcholine hydrochloride (ACh) and sodium nitroprusside (SNP), respectively. Effects of the nitric oxide synthase (NOS) substrate L...

... Ca 3.1 and K Ca 2.3 expression, and ultimately attenuates relaxation mediated by nitric oxide- and endothelium-derived hyperpolarizing factor. [email protected] 1 02 2016 19 05 2016 1 9 2016 Eyeballs were removed for blood samples before the mice were sacrificed...

...Reza Aghamohammadzadeh; Richard D. Unwin; Adam S. Greenstein; Anthony M. Heagerty Introduction: Perivascular adipose tissue (PVAT) surrounds most vessels in the human body. Healthy PVAT has a vasorelaxant effect which is not observed in obesity. We assessed the contribution of nitric oxide...

... syndrome even though nitric oxide (NO)-mediated vasodilation is attenuated. Therefore, we examined the PAR2 mechanisms underlying metabolic syndrome-resistant vasodilation in SHRSP.ZF aortas with ageing. In isolated aortas, the PAR2 agonist 2-furoyl-LIGRLO-amide (2fly) caused vasodilation...

...Masashi Tawa; Takashi Shimosato; Hirotaka Iwasaki; Takeshi Imamura; Tomio Okamura Background/Aims: The present study investigated the mechanism by which peroxynitrite impairs vascular function through the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP pathway. Methods: Mechanical responses...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endothelium Nitric oxide Vasodilation Coronary artery Rheumatoid arthritis Rheumatoid arthritis (RA) is an autoimmune condition characterized by chronic synovitis...

...Yohannes T. Ghebremariam; Ngan F. Huang; Swetha Kambhampati Thiruvengadam; Katharina S. Volz; Gururaj G. Joshi; Eric V. Anslyn; John P. Cooke Background: Nitric oxide (NO), a potent vasodilator and anti-atherogenic molecule, is synthesized in various cell types, including vascular endothelial cells...

... completely abolished BK-induced vasodilation. Conclusion: Venous endothelial dilator function is not affected by TMP elevation. BK-induced vasodilation is completely dependent on the presence of functional endothelial cells and mediated in part by nitric oxide, BK Ca and SK Ca channels, while...

... in normotensive experimental animals and human subjects have revealed that a key feature of this pressure-independent effect of dietary salt is a profound reduction in vascular nitric oxide (NO) bioavailability that limits endothelium-dependent dilation. This reduction in NO is strongly associated with increased...