... A 2 analogue U46619-stimulated Ca 2+ spike activity but had no effect on the U46619-induced increase in the basal level of Ca 2+ . The voltage-sensitive L-type Ca 2+ channel blocker nifedipine (100 n M ) reduced Ca 2+ spike activity similar to G-1. Pharmacological, but not physiological...

... responsiveness. Nifedipine (1 and 10 µ M) suppressed spontaneous myogenic responses. The αi-adrenoceptor agonist phenylephrine (1 and 10 µ M), when administered at 20 mm Hg, elicited constriction and vasomotion, and potentiated myogenic constriction to subsequent pressure elevation. Nifedipine (1 and 10 µ M...

... in aortic strips from adult female, pregnant and old male rats. Aortic oscillations were partially inhibited by indomethacin, ibuprofen and nordihydroguaiaretic acid (NDGA), and completely inhibited by indomethacin plus NDGA, nifedipine, low external calcium &(< 1 m M ) and pre-treatment...

...Mabayoje A. Oriowo; Robert R. Ruffolo, Jr. The effects of chlorethylclonidine, WB 4101 and nifedipine on norepinephrine-induced contractions of rat, guinea-pig, rabbit and dog aortae were investigated in order to characterize the α 1 -adrenoceptor subtype(s) present in the aortae of these different...

... in a concentration-dependent manner, but had no effect on the response to methoxamine (MO). Nifedipine (10 –6 and 10 –5 M ) had no significant effect on responses to CL and MO, but it had a noticeable inhibitory effect on the response to BHT-920. In tissues pretreated with phenoxybenzamine, nicorandil (10 –5 M...

... 10-9 and 10–5 M. The order of potency in aorta was: mesudipine = verapamil > diltiazem > nifedipine. Of the three drugs studied in vena cava, the order of potency was: mesudipine > verapamil > bepridil. It is concluded that, in both preparations of arterial and venous VSM, mesudipine...

...-precontracted aorta. The L -NNA-resistant relaxations by ACh in MBMA precontracted with phenylephrine were eliminated in the presence of 1 μ M nifedipine where contractions were independent of L-type Ca 2+ channel activation. In FBMA precontracted with phenylephrine, the L -NNA-resistant relaxations were only...

... and moderate hypoxia (PO 2 35 and 20 mm Hg, respectively) elicited significant relaxation. Pretreatment with the L-type Ca 2+ channel antagonist nifedipine completely inhibited mild hypoxic relaxation and diminished relaxation under moderate hypoxia, whereas glibenclamide, a blocker of adenosine triphosphate...