...Shu-Jie Guo; Peng Zhang; Ling-Yun Wu; Guan-Nan Zhang; Wen-Dong Chen; Ping-Jin Gao Phenotypic transformation from adventitial fibroblasts (AFs) to myofibroblasts (MFs) is critical for vascular remodeling. Septin 2 was found to be downregulated during the differentiation of AFs to MFs induced...

... assessed the distribution of transplanted peripheral blood mononuclear cells (PBMCs) in granulation tissue formation, and evaluated their possible transdifferentiation into myofibroblasts. Methods: Silastic tubes were inserted into the peritoneal cavity of rats, followed by injection of PKH26-labelled...

... suggesting inward migration. On day 2, proliferating cells stained positive only for vimentin. By days 5–14, proliferating cells stained for α-smooth-muscle actin, a phenotype characteristic of myofibroblasts. Conclusion: These results indicate that cell proliferation and apoptosis occur simultaneously...

...Julie H. Campbell; Johnny L. Efendy; Chih-Lu Han; Adeeb A. Girjes; Gordon R. Campbell This study utilized both in vivo and in vitro techniques to investigate whether cells of bone marrow origin can differentiate into smooth muscle-like cells (myofibroblasts) with contractile filaments and proteins...