... small-caliber human omental and mouse tail resistance arteries. We show that GABA A receptors modulate both plasma membrane potential and calcium responses in primary cultured cells from human resistance arteries. Lastly, we demonstrate functional physiologic modulation of myogenic tone via GABA...

... potential is more positive than the resting membrane potential enabling Cl – to be a depolarizing ion upon activation of a Cl – conductance. Cl – currents are involved in different vascular responses suggesting a number of different Cl – channels. All known Cl – channel families, with the exception...

...: In isolated segments of artery, isometric tension and simultaneous measurements of either smooth muscle membrane potential or intracellular [Ca 2+ ] ([Ca 2+ ] SMC ) changes were recorded. Results: In the absence of L -NAME, asynchronous propagating Ca 2+ waves were recorded that were sensitive to block...

... and charybdotoxin (CTX). The membrane potential response was accompanied by an increase in intracellular Ca 2+ [Ca 2+ ] i . Pretreatment of endothelial cells with 20 µ M ATP, 0.2 µ M bradykinin or 0.1 µ M platelet-aggregating factor, which induced either a transient hyperpolarization or no response, changed...

...B. Juul; L. Plesner; C. Aalkjær We have investigated excitation-contraction coupling mechanisms associated with the activation of purinoceptors and putative pyrimidinoceptors by assessing the effects of ATP and UTP on cytoplasmic Ca 2+ activity ([Ca 2+ ] i ), membrane potential (E m ) and force...

...Holger Nilsson; Peter E. Jensen; Michael J. Mulvany The role of membrane potential-dependent and independent regulation of the intracellular free calcium concentration ([Ca 2+ ] i ) was assessed in the mesenteric small arteries of Wistar rats. [Ca 2+ ] i was determined by Fura-2 fluorescence...

...R.M. Wadsworth; T.O. Neild Membrane potential and tension were simultaneously recorded in ileal arteries isolated from rabbits with perinephritis hypertension and from sham operated controls. Stimulation of perivascular nerves with single pulses produced excitatory junction potentials, action...

... + channels Membrane potential Calcium Bloodvessels 1990;27:246-257 © 1990 S. Karger AG. Basel 0303-6847/90/0275-0246S2.75/0 Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses Gabor M. Rubanyia, Ana D. Freayb, Katalin Kauserc, Anthony Johns3...

.... The apparent affinity of the dihydropyridine binding site is related to the proportion of a high- and a low-affinity state which is regulated by membrane potential but could also be dependent upon other factors such as G proteins. Among Ca antagonists, a subgroup of agents exhibiting voltage dependence may...

...M.J. Mulvany; L.M. Videbœk; A.D. Hughes; C. Aalkjœr The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential...

...William W. Fleming A review of research on the relationship between the regulation of cellular sensitivity to drugs and transmitters and membrane potential is presented, with an emphasis on experiments with the rabbit saphenous artery. Chronic depression of the adrenergic innervation...

... hyperpolarization within several seconds after the addition of potassium. This hyperpolarization is believed to be caused by electrogenic ion transport since it exceeded the expected membrane potential based on the potential calculated from potassium concentrations, ER. Hyperpolarization declined within 5–15 min...

... vein. In guinea pig portal vein, inhibition by angiotensin and vasopressin was associated with an increase in membrane potential which was, on average, smaller than that produced by isoprenaline, and with a suppression of spike discharges. Tachyphylaxis of the responses to angiotensin and vasopressin...

... of the concentration-response curves to DCEBIO were performed using a two-way analysis of variance (ANOVA) with repeated measures and multiple comparisons were made using a Student-Newman-Keuls test. Statistical comparisons of the membrane potential responses to DCEBIO were performed using a one-way ANOVA. Differences...

... and isobaric force development of noradrenaline-activated segments of rat mesenteric small arteries in which the endothelium was removed. We further measured the concentration-dependent effect of 8Br-cGMP on VSMC membrane potential, spatially resolved [Ca 2+ ] i and VSMC membrane conductance. Results: With 300...

..., instructions or products referred to in the content or advertisements. Cerebral arteries Cyclic nucleotides Cytochrome P 450 Arachidonic acid Hyperpolarization Hypoxia Membrane potential Vascular endothelium Besides nitric oxide (NO) and prostacyclin, another relaxing factor, termed...

...Holger Nilsson; Lars M. Videbæk; Catalin Toma; Michael J. Mulvany We have investigated the effect of intracellular calcium levels for membrane potential during noradrenaline application in isolated small arteries. Rat mesenteric small arteries were mounted for isometric tension measurement. Smooth...