... is a complex integration of cholesterol penetration, inflammatory cell infiltration, vascular smooth muscle cell (VSMC) migration, and neovascular invasion. A family of matrix-degrading proteases, the matrix metalloproteinases (MMPs), contributes to all phases of vascular remodeling. The contribution...

.... Hypertension Matrix metalloproteinases Transcription factors CARDIOVASCULAR REMODELLING Dear Editor, Berry et al. [ 1 ] have reviewed insights into the activity, differential expression, regulation and functions of matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases...

... treatment (3 U/day) decreases smooth muscle cell (SMC) migration and neointimal growth after carotid angioplasty in normal rats maintained at normoglycemia by oral glucose. SMC migration requires limited proteolysis of the extracellular matrix, which is mediated by matrix metalloproteinases (MMPs...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Porphyromonas gingivalis Neointima Matrix metalloproteinases Arterial injury Periodontal disease...

... plaque composition, the concentration of matrix metalloproteinases (MMPs) in the atherosclerotic plaque and the systemic circulation. Methods: Ninety apolipoprotein E-deficient (apoE –/– ) mice (45 male) were randomized to the following groups (n = 15 each): control male/female; sedentary male/female...

... of VEGFR-2 signaling leads to apoptosis in capillaries [ 10 ], but no molecular mechanism has been proposed for the enhanced endothelial apoptosis in hypertension. The matrix metalloproteinase (MMP) family includes 24 members that share structural domains, but differ in substrate specificity, cellular...

...Anita C. Thomas; Andrew C. Newby Long-term success in vein grafting for bypassing arteries blocked by atherosclerosis is limited by migration and proliferation of smooth muscle cells to form a neointima. Matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9, are implicated in neointimal...

...Yulan Zhao; Shuli Zhou; Chew-Kiat Heng Background: Although serum amyloid A (SAA) is an established biomarker of coronary artery disease (CAD), its direct role in matrix degradation is obscure. This study investigated the effect of SAA on the expression of matrix metalloproteinase-10 (MMP-10...

... characterized by infiltration of monocytes and enhanced expression of pro-inflammatory cytokines and chemokines, e.g. IL-1 and MCP-1, and vascular remodeling as indicated by wall thickening, fibrosis and expression of VEGF and the matrix metalloproteinases MMP-2 and MMP-9 [ 5,6,7 ]. In addition, increased...

... and MVD. A positive correlation was observed between the ratio of Ang-2/Ang-1 and MVD. Ang-2 expression was correlated with matrix metalloproteinase-2 (MMP-2) activity. Immunohistochemical staining of Ang-1 was observed in smooth muscle cells, whereas Ang-2 was detected in endothelial cells, smooth muscle...

...Antony Vinh; Tracey A. Gaspari; Hong Bin Liu; Lovisha F. Dousha; Robert E. Widdop; Anthony E. Dear Background/Aims: Aberrant expression of components of the matrix metalloproteinase (MMP) enzyme system is implicated in abdominal aortic aneurysm (AAA) formation. We aimed to investigate the influence...

... and sulfatases was measured using colorimetric methods. To assess matrix metalloproteinases (MMPs), Western blot and zymography were performed. The activity of endoglycosidase degrading chondroitin-4-sulfate was lower in the AAA wall. Endoglycosidase degrading heparan sulfate and dermatan sulfate, arylosulfatase...

... phenotype retaining their full contraction capacity. However, an increase in the expression level of matrix metalloproteinase-2 and -9, as well as a decrease in plasminogen activator inhibitor-1 expression were observed in arteries exposed to oscillatory shear stress when compared to arteries exposed...

...Michael Browatzki; Dina Larsen; Carolein A.H. Pfeiffer; Sven G. Gehrke; Joachim Schmidt; Alexander Kranzhöfer; Hugo A. Katus; Roger Kranzhöfer The renin-angiotensin system contributes to atherogenesis. Matrix metalloproteinases (MMP) are thought to participate in plaque destabilization through...

..., is important [ 6, 7 ]. Inhibition of collagen degradation via matrix metalloproteinase (MMP) inhibitors resulted in diminished arterial shrinkage after balloon angioplasty [ 8, 9 ]and diminished arterial enlargement after sustained blood flow changes [ 10 ], although others found no effect of MMP...