...Klas Österberg; Joakim Håkansson; Erney Mattsson Introduction: Smooth muscle cells (SMCs) with an origin separate from the local vein wall contribute to formation of intimal hyperplasia (IH) in mouse vein grafts. The recruitment pathway of these cells has not been defined, but circulating...

... AVF-vein and artery intimal hyperplasia, (2) angioplasty decreased eNOS protein expression in AVF-vein and artery at 21 days post-AVF creation and remained decreased in the AVF-vein angioplasty group at 35 days, (3) angioplasty increased AVF-vein and artery α-SMA expression within the intimal region...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Restenosis Peripheral angioplasty Intimal hyperplasia Stent Carbon...

... by the attenuation of proinflammatory activities in the remodeled vasculature. Results are presented as means ± SD. Data were compared using an unpaired t test or ANOVA as appropriate. p < 0.05 was considered statistically significant. HMG-CoA reductase inhibitors Inflammation Intimal hyperplasia...

...) after surgery. One group of animals was injected with a potent irreversible LOX inhibitor daily for 30 days. Results: Intimal hyperplasia increased in thickness until 90/180 days postsurgery. Elastin showed great expression in the neointima at 14/30 days and in the media at 90/180 days. LOX/LOXL1 were...

... cell migration to the injury site and maintenance of cell integrity by inhibition of apoptosis and SMC dedifferentiation. Sirolimus Imatinib mesylate Intimal hyperplasia Restenosis Smooth muscle cells The success of angioplasty and endovascular surgery is severely limited...

...Frits N.G. Doornekamp; Cornelius Borst; Mark J. Post After balloon angioplasty, retarded endothelial cell recoverage of the injured segment may lead to enhanced intimal hyperplasia. We tested the hypothesis that long lesions result in more intimal hyperplasia than short lesions due to a prolonged...

...Frits N.G. Doornekamp; Cornelius Borst; Mark J. Post Interventional-injury-induced intimal hyperplasia involves smooth muscle cell proliferation that may be limited by endothelial cell coverage. We hypothesized that endothelial cell coverage modulates intimal hyperplasia. Therefore rabbit carotid...

... suggest that increased pulsatile deformation of veins grafted into an arterial position may play a role in intimal hyperplasia. Since intimal hyperplasia occurs at the vein/arterial interface of the graft, SMC hyperplasia could be due to the proliferation of either aortic or venous SMCs. Therefore, we...

...Lieselotte van Erven; Mark J. Post; Evelyn Velema; Cornelius Borst Angioplasty inflicts damage to the arterial wall. We studied whether augmented medial smooth muscle cell necrosis leads to augmented intimal hyperplasia and thus aggravates restenosis. Sixty-three normal femoral arteries of New...

... as an antirestenotic agent in clinical trials. Heparin Smooth muscle cell Cell proliferation Intimal hyperplasia 23 9 2008 1998 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized...

... of intimal hyperplasia. The effects of ex vivo treatment with desferrioxamine Mn +3 (DFMn), a cell-permeable free radical scavenger, on the development of intimal hyperplasia in experimental vein grafts was examined. Twenty New Zealand white rabbits received a reversed vein interposition bypass graft...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chemokines Intimal hyperplasia...

... vasorelaxation of collared-vessels was not altered by either peptide. Intimal hyperplasia induced by the collars was not prevented by peri-arterial natriuretic peptides. In additional rabbits (n = 6), CNP (100 pmol/h) given directly into the lumen of collared carotid arteries for 7 days reduced neointima...

...Klas Österberg; Erney Mattsson Altered flow conditions are presumed to cause stenosis in vein grafts due to exaggerated neointimal formation. The aim of this study was to establish a mouse model of flow-regulated intimal hyperplasia (IH) in vein grafts. The caval vein was grafted into the common...

.... Methods and Results: Wild-type (WT) mice (n = 40) and hyperlipidemic apolipoprotein-E-deficient (apoE –/– ) mice (n = 40) received normal chow or chow containing simvastatin 100 mg/kg/day prior to bilateral femoral artery wire injury. Intimal hyperplasia and plasma cholesterol concentration were...

.... Intimal hyperplasia (IH), a fibroproliferative thickening of the intima, is the primary cause of vein graft failure after the first postsurgical year [ 1, 2 ]. No treatments exist for IH, and its etiology is not fully understood. The process of IH development in vein grafts resembles arterial restenosis...

... and 2 months postoperatively. The anastomoses were wrapped with polymer matrices containing confluent porcine aortic endothelial cells (PAE; n = 14) or control matrices without cells (n = 10). PAE implants significantly reduced intimal hyperplasia at the anastomotic sites compared to controls by 68% (p...

...Per Fogelstrand; Bo Risberg; Erney Mattsson Intimal hyperplasia is a common complication following vascular interventions. To understand the underlying pathophysiology, the focus has mainly been on the intima and media. The adventitia has been less investigated, although adventitial hyperplasia...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Fibroblasts Intimal hyperplasia Myofibroblasts Neointima Smooth muscle differentiation...