...Caitlin Wilson; Janice M. Thompson; Leah Terrian; Adam D. Lauver; Emma D. Flood; Gregory D. Fink; Lisa Sather; Sudin Bhattacharya; G. Andres Contreras; Stephanie W. Watts Introduction: Tunica media extracellular matrix (ECM) remodeling is well understood to occur in response to elevated blood...

... to in the content or advertisements. Graphic Abstract Graphic Abstract. Aortic dissection Aortic dilation Experimental model Vasodilators Smooth muscle cell Extracellular matrix Thoracic aortic aneurysms and dissections (TAADs) are serious pathologies, in part associated with age...

..., instructions or products referred to in the content or advertisements. Fibroblasts Glycemic variability Diabetes Vascular access Extracellular matrix AKR-2B cells were preconditioned in hyperglycemic milieu (media containing 30 m M glucose). All experiments were performed...

...V.A. Belo; Danielle A. Guimarães; Michele Mazzaron Castro For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells (VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs to be degraded to favor VSMC migration. Many proteases...

... structural changes of resistance arteries and stiffening of the arterial wall, including remodeling of the extracellular matrix. We hypothesized that biopsies of the human parietal pericardium, obtained during coronary artery bypass grafting or cardiac valve replacement surgeries, can serve as a source...

...Rong Li; Mao Luo; Meiping Ren; Ni Chen; Jiyi Xia; Xin Deng; Min Zeng; Kai Yan; Tingting Luo; Jianbo Wu Background: Vascular endothelial growth factor (VEGF) plays a key role in regulating angiogenesis, and this process is largely dependent on the newly formed extracellular matrix (ECM). The levels...

... transversal to the main axis of the wall. The recognition of this pattern and the degradation/fragmentation of collagen and elastic fibrils facilitates understanding of why the wall is weak and affected by aneurysms and dissections. Aorta Extracellular matrix Collagen Elastic system fibers Aneurysm...

... to inflammatory stimuli, migrate and grow new blood vessels, lay down extracellular matrix, and take up low-density lipoproteins. We also examined the ESC-EC ability to upregulate NO in response to shear stress and downregulate NO in response to pro-inflammatory TNF-α activation. Functional responses of ESC-EC...

...Luisa A. DiPietro; Denise R. Nebgen; Peter J. Polverini Vascular endothelial cells are an established source of thrombospondin 1 (TSP1), a multifunctional extracellular matrix molecule. TSP1 appears to play an important role in modulating endothelial cell functions such as proliferation, migration...

...M. Rodríguez; G. Pascual; A. Cifuentes; B. Perez-Köhler; J.M. Bellón; J. Buján Background: Extracellular matrix deposition is the main factor inducing stenotic lesions in arterial grafts. Lysyl oxidases (LOX) play a key role in stabilizing collagen and elastin. Objective: To examine the repair...

... the increase in upstream shear rate caused an upstream dilation that was NO mediated (for example flow-mediated dilation). 19 08 2009 8 01 2010 6 7 2010 Vascular endothelial cell growth factor A Basic fibroblast growth factor Permeability Extracellular matrix Growth...

...Jozef L. Van Herck; Dorien M. Schrijvers; Guido R.Y. De Meyer; Wim Martinet; Cor E. Van Hove; Hidde Bult; Christiaan J. Vrints; Arnold G. Herman Aim: Transglutaminase 2 (TG2) is important for the deposition and stability of the extracellular matrix via effects on cross-linking of matrix proteins...

... Membrane type 1-matrix metalloproteinase Decorin Extracellular matrix Angiogenesis plays a critical role in a variety of pathological conditions such as tumor growth and metastasis, diabetic retinopathy, and wound healing [ 1, 2 ]. Identification of the factors that contribute to the physiology...

... to tenascin substrata. Tenascin reduced focal adhesion integrity in confluent endothelial and smooth muscle cell cultures. Angiotensin II-induced migration of endothelial and smooth muscle cells was accompanied by tenascin deposition within extracellular matrix migration trails. Tenascin may function both...

... of exogenously added growth factors. Since it has been hypothesized that extracellular matrix proteoglycans may influence the growth and differentiation of vascular smooth muscle cells, we examined the ability of matrix derived from these cells to influence vascular smooth muscle cell proliferation. To produce...

... and heparitinase each caused a dramatic reduction of the large proteoglycan granules of the extracellular matrix, only exposure to heparitinase and thrombin caused a reduction in the small proteoglycans which populate the basement membrane of smooth muscle cells. Of the subendothelium-bound 125 I-antithrombin III...

... aortas (p < 0.01 vs. nondigested), but decreased their reactivity towards platelets on umbilical arteries (p < 0.01 vs. nondigested). The ultrastructural study of the interacting platelets revealed that aggregates, when present, were found on the extracellular matrix underlying endothelial cells...

...Gene Liau; Jeffrey A. Winkles; Samuel Cannon; Lih Kuo; William M. Chilian Growth factor and extracellular matrix gene expression by vessel wall cells influence the development of arterial lesions. In this study, we compared the level of acidic and basic fibroblast growth factor mRNA expression...

.... Independent of the inciting stimuli (biochemical/mechanical), TAA development proceeds by a multifactorial process influenced by both cellular and extracellular mechanisms, resulting in alterations of the structure and composition of the vascular extracellular matrix (ECM). While the role of enhanced ECM...

...Pedro Geraldes; Pascale Geoffroy; Isabelle Cloutier; Martin G. Sirois; Jean-François Tanguay Background: Percutaneous transluminal coronary angioplasty (PTCA) and stent implantation are associated with intimal hyperplasia and extracellular matrix (ECM) accumulation, resulting in restenosis. We...