... by endothelin-1. We hypothesized that endothelin receptor blockade may improve CBF in AD. Methods: We investigated cerebrovascular reactivity in a mouse model of AD (APP-PS1; 5-6-month-old male subjects). We assessed the in vivo response to normoxic hypercapnia and in vitro FMD in isolated cerebral...

... and immunohistochemistry. Freshly isolated preparations and vessels incubated (24 h) with/without endotoxin (10 µg·ml –1 ) were compared. The contractile responses to phenylephrine, UK14.304, U46619, PGF 2 α , endothelin-1 (ET-1) and sarafotoxin were recorded, as well as the relaxation in response to acetylcholine...

...Erik N.T.P. Bakker; Peter J.W. van der Linden; Pieter Sipkema Vascular endothelial cells release dilatory compounds like nitric oxide and prostacyclin, as well as contractile factors like endothelin-1 (ET-1). We investigated the interaction of ET-1 with nitric-oxide-mediated dilation in cannulated...

...Masakazu Kohno; Koji Yokokawa; Takeshi Horio; Kenichi Yasunari; Koh-ichi Murakawa; Miwako Ikeda; Tadanao Takeda Cultured porcine endothelial cells (EC) released immunoreactive endothelin-1 (ir-endothelin-1) and big endothelin-1 (ir-big endothelin-1) into the medium in a time-dependent way. Reverse...

...) results in cardiovascular malformations. These abnormalities are similar to malformations observed in knockout mice studies of components of the endothelin-1 (ET-1)/endothelin-converting enzyme-1/endothelin-A receptor pathway. In previous studies we demonstrated that cardiac ET-1 expression is decreased 3...

...Jiazhen Dai; Cheng-Han Lee; Damon Poburko; Tania Szado; Kuo-Hsing Kuo; Cornelis van Breemen Endothelin-1 (ET1) is an endogenous vasoconstrictor released by the vascular system to regulate the contractility of vascular smooth muscle cells (VSMC). It is implicated in the pathogenesis of hypertension...

... Endothelin-1 Von Willebrand factor The endothelium has been recognized as a key component in the regulation of blood vessels under physiological and pathological conditions [ 1 ]. Studies on endothelial gene expression are therefore of great interest, but meet with technical difficulties when native...

...Amarjit S. Sethi; Delphine M. Lees; Julie A. Douthwaite; Anne B. Dawnay; Roger Corder Background: Elevated plasma homocysteine (Hcy) is a risk factor for coronary disease. The objective of this study was to investigate whether Hcy either alone or in high glucose conditions induces endothelin-1 (ET...

... in animals and humans. These effects are mediated by the inhibition of endothelin-1 (ET-1) production in endothelial cells. To clarify the mechanism of this inhibition, we investigated the effect of heparin on transcriptional regulation of the ET-1 gene in bovine aortic endothelial cells (BAEC) cultured...

...Erik N.T.P. Bakker; Carsten L. Buus; Ed VanBavel; Michael J. Mulvany Remodeling of resistance arteries is a key feature in hypertension. We studied the transition of vasoconstriction to remodeling in isolated rat skeletal muscle arterioles. Arterioles activated with 10 n M endothelin-1 showed...

...Shoshana Keynan; Mogher Khamaisi; Rachel Dahan; Kay Barnes; Carolyn D. Jackson; Anthony J. Turner; Itamar Raz Endothelin-1 (ET-1) is both a potent vasoconstrictor and mitogenic factor that has been implicated as a cause of the micro- and macrovascular complications of diabetes mellitus. The pathway...

...Yung-Ho Hsu; Jin-Jer Chen; Nen-Chung Chang; Cheng-Hsien Chen; Ju-Chi Liu; Tso-Hsiao Chen; Cherng-Jye Jeng; Hung-Hsing Chao; Tzu-Hurng Cheng Background: Circulating angiotensin II (Ang II) increases vascular endothelin-1 (ET-1) tissue levels, which in turn mediate a major part of Ang II-stimulated...

...Amauri Cruz; Charles Parnot; Domenico Ribatti; Pierre Corvol; Jean-Marie Gasc We investigated the angiogenic properties of endothelin-1 (ET-1) using a novel experimental approach involving the constant production and release of ET-1, which was achieved by grafting stably transfected Chinese hamster...

... the endothelial production and release of endothelin-1. The investigation of insulin resistance in the vasculature provides not only a unique and physiologically relevant window onto vascular pathology, but also an opportunity for therapeutic targeting in individuals affected by the clinical states of insulin...

... AB, Bending MR: Amelioration of hepatorenal syndrome with selective endothelin-A antagonist. Lancet 1996;347:1842–1843. 13. Leivas A, Jiménez W, Lamas S, Bosch-Marcé B, Oriola J, Clària J, Arroyo V, Rivera F, Rodés J: Endothelin-1 does not play a major role in the homeostasis of arterial pressure...