...) inhibition stimulates endothelial microvesicles (EMVs) release and (2) the effect of EMVs derived from eNOS-inhibited cells on endothelial cell eNOS, inflammation, apoptosis, and tissue-type plasminogen activator (t-PA). Methods: Human umbilical vein endothelial cells (HUVECs) were treated with the eNOS...

... of rivaroxaban on human umbilical vein endothelial cells exposed to acute and chronic H 2 O 2 -induced oxidative stress. Results: Rivaroxaban dose-dependently suppressed syndecan-1, a key component of the glycocalyx, shedding from cell surface, and enhanced protease-activated receptor (PAR)1-PAR2...

... stress marker 4-hydroxynonenal (4HNE), and oxidative stress protective marker nuclear factor erythroid 2-related factor 2 (NRF2) were evaluated. Results: In saline patient veins, histological analysis revealed a limited luminal layer, suggesting a loss of endothelial cells (ECs). Immunofluorescent...

... to in the content or advertisements. 2023 Gap junction communication Endothelial cells Vascular function Conducted vasodilation Arterial blood pressure The vasculature is a complex network designed to transport the blood pumped by the heart through the arterial circulation to supply oxygen...

... expression in vascular smooth muscle cells (vSMC), endothelial cells (EC), and pericytes. Cx43 is thought to coordinate homocellular signaling within EC and vSMC. Cx43 gap junctions also function as conduits between different cell types (heterocellular signaling), between EC and vSMC at the myoendothelial...

... multiflorum Thunb, has been shown to have strong antioxidant and antiapoptotic activities. In the present study, we investigated the protective effect of TSG on apoptosis induced by high glucose in human umbilical vein endothelial cells (HUVECs) and the possible mechanisms. Our data demonstrated that TSG...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vascular reactivity Endothelial dysfunction Endothelial cells Nitric oxide...

...) is an important regulator of angiogenesis. However, the role of direct current EFs in eNOS activity and expression in association with angiogenesis of endothelial cells has not been investigated. In the present study, we stimulated human umbilical vein endothelial cells (HUVECs) with EFs and evaluated...

... of atrial fibrillation. Observational data hypothesized a cardioprotective effect. In an in vitro endothelial cell-platelet model, we evaluated the molecular atheroprotective effects of dronedarone. Methods: Following a 24-h incubation of human umbilical vein endothelial cells (HUVECs) with dronedarone...

...Filipa Cunha; Ann M. Rajnicek; Colin D. McCaig Natural direct current electric fields (DC EFs) within tissues undergoing angiogenesis have the potential to influence vessel formation, but how they affect endothelial cells is not clear. We therefore quantified behaviours of human umbilical vein...

...Claudio Molinari; Vera Morsanuto; Simona Polli; Francesca Uberti This work demonstrates the cooperative effect of Q10, vitamin D 3, and L -arginine on both cardiac and endothelial cells. The effects of Q10, L -arginine, and vitamin D 3 alone or combined on cell viability, nitric oxide, and reactive...

...Vasileios G. Chantzichristos; Fani Gkrozou; Konstantinos Stellos; Minas E. Paschopoulos; Alexandros D. Tselepis Background/Aims: Platelets affect endothelial progenitor cell (EPC) functionality, inducing their differentiation into mature endothelial cells. However, it remains to be established...

.... Coronary artery disease Endothelial cells microRNA Cardiovascular diseases (CVD) account for nearly one-third of deaths worldwide. Coronary artery disease (CAD) is the most common type of CVD and is predicted to be the most important death-related problem worldwide in the next 20 years...

... on the critical role of the Cables1/p21 pathway, which inhibits cell proliferation and induces cell senescence in human umbilical vein endothelial cells. Moreover, we confirmed that silencing of Cables1 promoted cell proliferation as well as increased resistance to angiotensin II-induced senescence, at least...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth factor Arterial injury Endothelial cells Inflammation Adenosine triphosphate Monocytes P2Y receptors...

... endothelial cells from wild-type (WT) but not Cx40 -/- mice. Because Cx40 knockout could result in nonspecific effects, this discovery may not establish the causal relationship between Cx40 and reduced coupling. Using the same cell culture model, we aimed to address this uncertainty by using the rescue...

... signaling in endothelial cells, pericytes and smooth-muscle cells to regulate vessel formation and remodeling in adult tissues. R-Ras suppresses VEGF-induced endothelial permeability and vessel sprouting while promoting normalization of pathologically developing vessels in mice. It attenuates VEGF receptor...

.... Results: We showed that the immunohistochemical quantification of the ingrowth of endothelial cells, based on CD31, was superior to the fluorometric quantification advised in the manufacturer's instructions. We optimised the explantation procedure, ensuring the complete recovery of the ingrown vessels...

...Claudia Schrimpf; Omke E. Teebken; Mathias Wilhelmi; Jeremy S. Duffield Background: Pericytes surround endothelial cells at the perivascular interface. Signaling between endothelial cells and pericytes is crucial for capillary homeostasis, as pericytes stabilize vessels and regulate many...

...Daniel Svensson; Olof Gidlöf; Karolina M. Turczyńska; David Erlinge; Sebastian Albinsson; Bengt-Olof Nilsson The microRNA-125a (miR-125a) is highly expressed in endothelial cells, but its role in vascular biology is not known. Endothelial cell proliferation and viability play an important role...