..., a negative association between diabetes (a major risk factor for atherosclerosis) and vascular aneurysmal disease has been observed. Investigating the biomechanical and histological properties of the aortic wall may shed light on the etiopathogenesis of aneurysms. Methods: This study involved 75 Wistar...

...Fang-Qiang Song; Hui-Min Zhou; Wei-Xuan Ma; Yu-Lin Li; Bo-Ang Hu; Yuan-Yuan Shang; Zhi-Hao Wang; Ming Zhong; Wei Zhang; Yun Ti Cell death-inducing DFF45-like effector C (CIDEC) is involved in diet-induced adipose inflammation. Whether CIDEC plays a role in diabetic vascular inflammation remains...

...Jiankun Cui; Bo Zhang; Min Gao; Baohai Liu; Cong Dai; Yumei Dong; FanJi Meng Endothelial dysfunction plays a central role in the patho­genesis of diabetic vascular complications. 2,3,5,4′-tetra­hydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from the roots of Polygonum...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diabetes Endothelial dysfunction...

...Ewelina Kreft; Kornelia Sałaga-Zaleska; Monika Sakowicz-Burkiewicz; Kamil Dąbkowski; Miroslawa Szczepánska-Konkel; Maciej Jankowski Diabetes through adenosine A1 receptor (A 1 R) and P2 receptors (P2Rs) may lead to disturbances in renal microvasculature. We investigated the renal microvascular...

...Rongrong Hou; Mingzhi Shen; Rutao Wang; Haitao Liu; Chao Gao; Jing Xu; Ling Tao; Zhiyong Yin; Tao Yin Diabetes mellitus (DM)-induced impairment of collateral formation has been demonstrated in subjects with coronary artery disease, which contributes to unfavorable prognosis among diabetic...

... conductance Ca 2+ -activated K + (BK) channel function in coronary smooth muscle cells (SMCs) of streptozotocin-induced diabetic rats. Methods: The effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on coronary BK channel open probabilities were determined using the patch clamp technique...

..., and that diabetic patients have worse clinical outcomes. The aim of this study was to determine the functional and gene expression outcomes of matrix metalloproteinase-2 (Mmp-2) silencing in fibroblasts cultured under hyperglycemia and euglycemia with hypoxic and normoxic stimuli. Materials and Methods: AKR-2B...

...Matthias Oelze; Maike Knorr; Swenja Schuhmacher; Tjebo Heeren; Christian Otto; Eberhard Schulz; Kurt Reifenberg; Philip Wenzel; Thomas Münzel; Andreas Daiber Objective: In previous studies we and others have shown that streptozotocin (STZ)-induced diabetes in rats is associated with vascular...

... and neovascularization in diabetic murine hind limb ischemia. Methods: After surgery in streptozotocin-induced diabetic mice, the mice were randomly assigned to the following 4 experimental groups: control (C), 100 µl of the sustained-release form of platelet-poor plasma (PPP), 100 µl of the solution form of PRP (PRP...

...Dimitria Vranes; Mark E. Cooper; Rodney J. Dilley Angiotensin-converting enzyme (ACE) activity and vascular mass are both increased in the mesenteric arteries of diabetic rats. As vascular hypertrophy may result from smooth muscle growth following increased formation of angiotensin II, we have...

... to local adhesion/aggregation especially of platelets activated by a preexisting pathology. Coronary artery disease, ischemic stroke and diabetes are examples of diseases associated with both hyperaggregable platelets and with impaired endothelial synthesis/release of antiplatelet paracrine mediators...

...Steven A. Moore; Glenn Bohlen; Bryan G. Miller; Andrew P. Evan Microvascular pathology is one of the major problems associated with prolonged diabetes mellitus. The purpose of the present study was to determine if anatomical cellular pathology of the cerebral cortical microvessels could be detected...

...M.L.J. Lagnado; R. Crowe; J. Lincoln; G. Burnstock The perivascular autonomic nerves of the major blood vessels on the ventral surface of the brain were studied in the streptozotocin-induced diabetic rat, an animal model for juvenile onset of diabetes. Histochemical and immunohistochemical...

...Marie Jirkovská; Lucie Kubínová; Jiří Janáček; Milena Moravcová; Vratislav Krejčí; Petr Karen Spatial arrangement and complexity of the capillary bed of placental terminal villi were analyzed in 9 normal and 11 diabetic placentas. Specimens were taken by systematic random sampling, fixed...

... that arterial MMP-2 activity is elevated in the presence of cardiovascular risk factors such as diabetes, hypertension, smoking and ageing, and that it correlates with the degree of kidney function. MMP-2 activity in internal mammary arteries (n = 37) was measured using gelatinolytic zymography, and cutoffs...

...Roopashree S. Dwarakanath; Saurabh Sahar; Linda Lanting; Nanping Wang; Michael B. Stemerman; Rama Natarajan; Marpadga A. Reddy Increased expression and activity of 12/15-lipoxygenase (12/15-LO) in vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetes and vascular...

..., endothelial cell apoptosis and ICAM-1 expression. Conclusions: Taurine may have a therapeutic role in reducing diabetic microvascular inflammatory injury and concomitant cardiac dysfunction. 28 11 2005 14 10 2006 11 12 2006 © 2007 S. Karger AG, Basel 2006 Copyright / Drug Dosage...

...Eliana H. Akamine; Elisa M. Kawamoto; Cristoforo Scavone; Dorothy Nigro; Maria Helena C. Carvalho; Rita de Cássia A. Tostes; Luiz R.G. Britto; Zuleica B. Fortes Diabetes-induced vascular dysfunction has mainly been studied in males. However, the mechanisms involved may not correspond to those...

...Ibrahim F. Benter; Mariam H.M. Yousif; Andrew J. Hollins; Sioned M. Griffiths; Saghir Akhtar Contribution of receptor tyrosine kinase activation to development of diabetes-induced renal artery dysfunction is not known. We investigated the ability of a chronic administration of genistein, a broad...