... Dilation in Isolated Rat Resistance Arteries Key Words Arteries Skeletal muscle Endothelin-1 Nitric oxide Prostacyclin Pressure myograph Endothelium Resistance vessels Cyclic GMP Spontaneous tone Abstract Vascular endothelial cells release dilatory compounds like nitric oxide and prostacyclin, as well...

... expressed in segments contracted with high K + , and in femoral artery essentially by endothelial NO release. Artery, rabbit Endothelium-derived relaxing factor Endothelium-derived hyperpolarizing factor Leukotrienes Cyclic GMP Acetylcholine Sodium nitroprusside Nandrolone treatment Original...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endothelium-derived relaxing factor Nitric oxide L -arginine Cyclic GMP N G -monomethyl- L -arginine Blood Vessels...

... stimuli to the biosynthesis of cyclic GMP in target cells. A variety of chemical factors interact with selective extracellular receptors and trigger the biosynthesis of NO from L -arginine. The unique chemistry of NO endows this molecule with the capacity to diffuse rapidly into nearby cells and stimulate...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Atrial natriuretic peptide Second messenger Receptors Cyclic GMP...

...Thomas M. Lincoln; Trudy L. Cornwell Cyclic GMP (cGMP) mediates the relaxing action of a variety of vasodilator drugs and endogenous vasodilator substances. Cyclic AMP (cAMP) mediates relaxation by β-adrenergic agonists as well as other activators of adenylate cyclase. Both second messengers appear...

.... However, working in the rat caudal artery and aorta, we found that neither cyclic AMP- nor cyclic GMP-mediated relaxations were diminished by even large doses of H-8. For example, in the caudal artery, relaxation of a phenylephrine contraction by 8-bromo-cGMP (10 –5 M ) was unaffected by H-8: control, 33...

...-monophosphate (GMP)-lowering agent, abolished the endothelium-dependent depression of tone induced by the agonists and converted the sensitivity of arteries with endothelium to that of endothelium-denuded preparations. M & B 22948, a selective cyclic GMP phospho-diesterase inhibitor, significantly inhibited...

... the cyclic GMP content of these coronary segments, an effect which was abolished by the nitric oxide (NO) synthase inhibitor N G -nitro- L -arginine ( L -NNA; 30 µ M) or by removal of the endothelium. L -NNA also strongly reduced the relaxation response to moexiprilat but only partially inhibited...

... of contractile preload. The vasorelaxation to ANF is associated with elevations of cyclic GMP via an activation of the particulate form of guanylate cyclase. Both species and regional-vascular differences exist, in vitro as well as in vivo, in the vasorelaxation response to ANF which may reflect an altered...

...-mediated vasodilation Aging Hypertension Cyclic GMP © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...

...Robert M. Rapoport; Ferid Murad Relaxation of the rat thoracic aorta induced by sodium nitroprusside, 8-bromo-cyclic GMP and cyclic nucleotide phosphodiesterase inhibitor M & B 22,948 was inhibited by exposure to K + -free solution and ouabain in a concentration-dependent manner. Relaxation...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cyclic AMP Cyclic GMP Vascular smooth muscle Nucleotide Vascular contractility...

...Petra Beranova; Christa Schott; Karel Chalupsky; Andrei L. Kleschyov; Jean-Claude Stoclet; Bernard Muller N ω -hydroxy- L -arginine ( L -NOHA), the stable intermediate of the nitric oxide synthase (NOS)-catalyzed reaction, can induce NO/cyclic GMP-dependent relaxation in the rat aorta...