... respiration and mitochondrial protein levels were similar in the large cerebral arteries of insulin-resistant Zucker obese rats and their lean controls. In this study, we extend our investigations into the mitochondrial dynamics of the cerebral vasculature of 14-week-old Zucker diabetic fatty obese (ZDFO...

... in the regulation of vascular tone. Activation of mitoK ATP channels in cerebral arteries causes vasodilation, with cell-specific contributions from the endothelium, vascular smooth muscles, and nerves. Preexisting chronic conditions, such as insulin resistance and/or diabetes, prevent preconditioning and impair...

...Kathryn H. Yuill; Alister J. McNeish; Yasuo Kansui; Christopher J. Garland; Kim A. Dora Background/Aims: In cerebral arteries, nitric oxide (NO) release plays a key role in suppressing vasomotion. Our aim was to establish the pathways affected by NO in rat middle cerebral arteries. Methods...

...Rodney J. Laing; Jan Jakubowski; Alyn H. Morice This study was designed to establish the in vitro pharmacological responses of rat middle cerebral arteries (MCA), and also their susceptibility to overnight cold storage at 4°C. MCAs were harvested from rats and pharmacological responses were studied...

...Germán Torregrosa; Juan B. Salom; Teresa Jover; José A. Alabadí; Francisco J. Miranda; Enrique Alborch The effects of MK-801 on the cerebral arteries and the possible involvement of the endothelium in such a response were examined using two experimental approaches: in vivo, by recording cerebral...

...George Mchedlishvili The article comprises mainly the personal views of the author on the following aspects of cerebral vasospasm: the definition of vasospasm; historical physiological concepts of cerebral bloodflow regulation; relation of spasm development in cerebral arteries to their functional...

...David R. Harder; Linda Brann; William Halpern Certain electrophysiological properties of smooth muscle cells within middle cerebral arteries of spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls were recorded with glass microelectrodes. Under control conditions...

..., instructions or products referred to in the content or advertisements. Cerebral arteries Cyclic nucleotides Cytochrome P 450 Arachidonic acid Hyperpolarization Hypoxia Membrane potential Vascular endothelium Besides nitric oxide (NO) and prostacyclin, another relaxing factor, termed...