..., instructions or products referred to in the content or advertisements. 2022 Atherosclerosis Notch Smooth muscle cell Phenotype switching Apolipoprotein E NIH Notch is an important signaling molecule in vascular development and repair and regulates atherosclerosis in a tissue...

... provide a unique opportunity to study the natural history of atherosclerotic disease progression and to identify underlying molecular mechanisms. ApoE–/– mice do not express apolipoprotein E, an important ligand for receptor-mediated removal of lipoproteins from the plasma; lack of ApoE causes low-density...

.... Methods and Results: Wild-type (WT) mice (n = 40) and hyperlipidemic apolipoprotein-E-deficient (apoE –/– ) mice (n = 40) received normal chow or chow containing simvastatin 100 mg/kg/day prior to bilateral femoral artery wire injury. Intimal hyperplasia and plasma cholesterol concentration were...