...Lydia Aslanidou; Bram Trachet; Linda Sasset; Goran Lovric; Nikolaos Stergiopulos; Annarita Di Lorenzo Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE−/− mice have been widely used...

...Wei Xu; Xiao Hu; Xi Qi; Rui Zhu; Chen Li; Yanjing Zhu; Shuai Yin; Liming Cheng; Rongrong Zhu Vitamin D has an important protective effect on chronic inflammatory disease. Angiotensin II (AngII) triggers vascular damage and plays a key role in vascular diseases via several mechanisms, including...

.... This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. We characterized apoE -/- rats and hypothesized that, similar to mice, they would develop dissecting AAAs. We created rats...

...Xiuli Zhou; Liwen Liang; Yan Zhao; Hong Zhang Introduction: This study aimed to investigate whether epigallocatechin-3-gallate (EGCG) shows antioxidant activity against angiotensin II (Ang II)-induced human umbilical vein endothelial cell (HUVEC) apoptosis. Materials and Methods: The viability...

... by angiotensin II (Ang II); however, the role of septin 2 in this process is still unknown. In this study, we investigate whether septin 2 contributes to the adventitial MF phenotypic modulation caused by Ang II. The decreased level of septin 2 and the increased expression of α-smooth muscle actin (α-SMA...

... impaired by elevated dietary salt intake or other pathological conditions. The major enzymatic route of angiotensin-(1-7) formation is from its precursor angiotensin II by the angiotensin-converting enzyme (ACE) homologue ACE2 [ 9,10 ]. The diverse physiological actions of angiotensin-(1-7...

...Nicoletta Charolidi; Grisha Pirianov; Evelyn Torsney; Stuart Pearce; Ken Laing; Axel Nohturfft; Gillian W. Cockerill Peroxisome proliferator-activated receptor γ agonists have been shown to inhibit angiotensin II (AngII)-induced experimental abdominal aortic aneurysms. Macrophage infiltration...

... production. Pericytes expressed angiotensin II (Ang II) receptors, and Ang II upregulated Nox4 expression. Hypoxic conditions also increased the Nox4 expression. Silencing of Nox4 significantly reduced ROS production and attenuated cell proliferation. Conclusion: Our study showed that Nox4 is a major...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Angiotensin II Cell migration Matrix metalloproteinases Peroxisome proliferator-activated receptor Tissue inhibitor of metalloproteinases Peroxisome proliferator-activated receptors...

... imaging analysis and the cGKI level by RT-PCR and Western blot in SHR and WKY RCEs. Plasmids encoding for enhanced green fluorescence protein or cGKIα-enhanced green fluorescence protein were transiently transfected in SHR RCEs, and [Ca 2+ ] i was evaluated. Angiotensin-II (AT-II) increased [Ca 2+ ] i...

... ameliorates portal hypertension but the influence on collaterals is unknown. Methods: Portal hypertension and cirrhosis were induced by portal vein (PVL) and common bile duct ligation (BDL). Hemodynamics, real-time PCR of angiotensin II receptors (AT 1 R, AT 2 R) in the left adrenal vein (LAV, sham...

.... Our objective was to explore the contribution of these cells to angiotensin II (Ang II)-induced aortic inflammation and adventitial expansion. Methods: Cytokine production by primary human aortic adventitial fibroblasts (AoAF) in tissue culture was detected using multiplex ELISA, and increases...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Angiotensin II ERK MAPK TGF-β1 Vascular alterations are a common feature...

...Corey S. Moran; Bradford Cullen; Julie H. Campbell; Jonathan Golledge Background and Aims: Osteoprotegerin (OPG) has been associated with abdominal aortic aneurysm (AAA) expansion. Angiotensin II (AngII) receptor blockade has been shown to reduce OPG expression in human AAA tissue. Interaction...

...Dimitria Vranes; Mark E. Cooper; Rodney J. Dilley Angiotensin-converting enzyme (ACE) activity and vascular mass are both increased in the mesenteric arteries of diabetic rats. As vascular hypertrophy may result from smooth muscle growth following increased formation of angiotensin II, we have...

...Kathrin J. Scheidegger; Jeanette M. Wood The aim of this study was to determine the effects of angiotensin II (Ang II) on the vascular wall, that are independent of its effects on systemic blood pressure. Ang II has been shown to have different effects on vascular growth in vitro and in vivo...

... in the SHR during interference with the functioning of the renin-angiotensin system. Conversely, under conditions of α-adrenoceptor blockade, angiotensin II can maintain an elevated blood pressure in the SHR. 1 08 1994 4 04 1995 24 9 2008 © 1995 S. Karger AG, Basel 1995 Copyright...

...Joseph Wiener; Donna M. Lombardi; Joe E. Su; Stephen M. Schwartz The present study focuses on the differential response of three branch levels of the mesenteric resistance arterial vasculature of 450-gram Sprague-Dawley rats infused continuously with angiotensin II (A-II) for 4, 7 and 14 days...

...Frank R.M. Stassen; Nicolaas J.H. Raat; Debbie L. Brouwers-Ceiler; Gregorio E. Fazzi; Jos F.M. Smits; Jo G.R. De Mey We examined effects of a 2-week infusion of angiotensin II (All, 250 ng· kg -1 •min -1 ) on properties of mesenteric resistance arteries (MrA) and superior epigastric arteries (SEA...

... whether substances with an effect on vascular growth influence the vascular branching pattern. We treated chick embryo CAMs daily from day 7 to day 14 postfertilization with 0.9% NaCl, angiotensin II (ANG-II), ANG-II in combination with different angiotensin receptor subtype antagonists, i.e., losartan...