...Amanda Balboa Ramilo; Nikiforos Chandrinos; Elefantia Tsichlia; Josefin Jönsson; Kevin Mani; Anders Wanhainen; Dick Wågsäter Introduction: Abdominal aortic aneurysm (AAA) development is inversely associated with diabetes mellitus. Targeting glucose metabolism seems to be a beneficial strategy...

...Yali Zhang; Jessamyn Bagley; Ho-Jin Park; Xuehong Cao; Elena Maganto-Garcia; Andrew Lichtman; Debbie Beasley; Jonas B. Galper Introduction: We demonstrated Toll-like receptor (TLR) 4 in the pathogenesis of angiotensin II (AngII)-mediated abdominal aortic aneurysm (AAA) formation. Here, we study...

... aneurysm repair Endovascular Abdominal aortic aneurysm Congestive heart failure Aneurysm CHF Abdominal aortic aneurysm (AAA) is a prevalent condition, affecting approximately 3% of the US population [ 1, 2 ]. Endovascular aneurysm repair (EVAR) has become the dominant treatment method for AAA...

... the animal model. Conclusions: These results evidenced the accumulation of HCit within aneurysmal aortas but do not allow concluding about the exact participation of protein carbamylation in the development of human abdominal aortic aneurysms. [email protected] 2 12 2022 11 10 2023...

...Davis B. McClarty; David C.S. Kuhn; April J. Boyd Computational fluid dynamics were used to assess hemodynamic changes in an actively rupturing abdominal aortic aneurysm (AAA) over a 9-day period. Active migration of contrast from the lumen into the thickest region of intraluminal thrombus (ILT...

...Jiaan He; Nan Li; Yichuan Fan; Xingzhi Zhao; Chengwei Liu; Xinhua Hu Background and Objective: Epidemiological evidence suggests that the antidiabetic drug metformin (MET) can also inhibit abdominal aortic aneurysm (AAA) formation. However, the underlying protective mechanism remains unknown...

...Hao Wang; Guodong Wei; Shuai Cheng; Ding Wang; Ju Ma; Shijie Xin Introduction: CD4-positive T lymphocytes (CD4 cells) play a significant role in human abdominal aortic aneurysm (AAA). However, we know little about the role of the different CD4 subtypes. Objective: We aimed to discover...

...Sophy Bengts; Levar Shamoun; Anne Kunath; Daniel Appelgren; Martin Welander; Martin Björck; Anders Wanhainen; Dick Wågsäter Introduction and Objective: Interleukin (IL)-32 is a pro-inflammatory cytokine not previously studied in relation to abdominal aortic aneurysm (AAA). The aim of this study...

.... Hemodynamic Abdominal aortic aneurysm Magnetic resonance imaging Doppler ultrasound Matrix metallopeptidase-9 Myeloperoxidase Although saccular and fusiform aneurysms are morphologically different, few comparative studies of these 2 types of aneurysm exist [ 1, 2 ]. These 2 morphologies differ...

...Yichuan Fan; Nan Li; Chengwei Liu; Haipeng Dong; Xinhua Hu Objective: The relationship between methionine (Met) and abdominal aortic aneurysm (AAA) has been previously demonstrated, but the mechanisms controlling this association remain unclear. This study investigated the potential contribution...

...Keisuke Hashimoto; Hirona Kugo; Hiroki Tanaka; Kazuko Iwamoto; Chie Miyamoto; Tetsumei Urano; Naoki Unno; Kohsuke Hayamizu; Nobuhiro Zaima; Tatsuya Moriyama Abdominal aortic aneurysm (AAA) is a vascular disease characterized by chronic inflammation in the infrarenal aorta. Most cases of AAA remain...

.... This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. We characterized apoE -/- rats and hypothesized that, similar to mice, they would develop dissecting AAAs. We created rats...

...Marike Gabrielson; Emina Vorkapic; Maggie Folkesson; Martin Welander; Andreas Matussek; Jan Dimberg; Toste Länne; Josefin Skogberg; Dick Wågsäter Introduction: Abdominal aortic aneurysm (AAA) is a complex and deadly vascular disorder. The pathogenesis of AAA includes destruction and phenotypic...

...Han Jiang; Qian Xia; Shijie Xin; Yun Lun; Jianbo Song; Dianjun Tang; Xun Liu; Jiancong Ren; Zhiquan Duan; Jian Zhang Background: Increasing evidence suggests that abdominal aortic aneurysm (AAA) is a T-cell-mediated autoimmune condition. This study investigates the epigenetic modifications...

.... Their expression pattern in an abdominal aortic aneurysm (AAA) is as yet unknown. The aim of this study was to make a detailed analysis of the expression of ADAMs 8, 9, 10, 12, 15 and 17, and their tissue inhibitors of metalloprotease (TIMP)-1 and TIMP-3 in patients with AAA. Design: The aortic vessel walls of AAA...

...Olivia J. Erdozain; Susan Pegrum; Vivienne R. Winrow; Michael Horrocks; Cliff R. Stevens Background/Aims: We sought to determine whether hypoxia is an initiating factor in the matrix metalloproteinase-2 (MMP-2) up-regulation observed in abdominal aortic aneurysm (AAA) and whether hypoxia-inducible...

...Corey S. Moran; Bradford Cullen; Julie H. Campbell; Jonathan Golledge Background and Aims: Osteoprotegerin (OPG) has been associated with abdominal aortic aneurysm (AAA) expansion. Angiotensin II (AngII) receptor blockade has been shown to reduce OPG expression in human AAA tissue. Interaction...

...Jiří Moláček; Vladislav Třeška; Jiří Kobr; Bohuslav Čertík; Tomáš Skalický; Vilém Kuntscher; Věra Křížková Background: Many studies have been performed in order to model abdominal aortic aneurysm (AAA) in an experimental animal, most commonly in small laboratory animals. In our study, we tried...

...Radosław Kowalewski; Krzysztof Sobolewski; Andrzej Małkowski; Małgorzata Wolańska; Marek Gacko The abdominal aortic aneurysm (AAA) wall represents an extreme example of arterial remodeling with disturbed elastin, collagen and proteoglycan metabolism. The aim of this study was to evaluate enzymes...

...Veronika Schulz; Doris Hendig; Martin Schillinger; Markus Exner; Hans Domanovits; Marianne Raith; Christiane Szliska; Knut Kleesiek; Christian Götting Abdominal aortic aneurysm (AAA) is characterized by dilatation of arterial walls, which is accompanied by degradation of elastin and collagen...