... platinum electrodes. Experiments were performed after treatment with phenoxybenzamine and in the presence of propranolol. Calcium-free solution and calcium antagonists reduced the relaxation. Chemical denervation with 6-hydroxydopamine reduced the relaxation induced by electrical stimulation...

... before and after adrenergic denervation produced by short-term, in vitro, 6-hydroxydopamine (6-OHDA) treatment. NE sensitivities of innervated vessels were the same in SHR and WKY rats, however, after 6-OHDA, not only did both ED 50 s show significant decreases (8.7- and 3.8-fold, respectively...

... denervation either had no effect on or enhanced the ear artery contractile response to 10 –6 to 10 -4 M propranolol. In contrast, the contractile response to propranolol was nearly abolished after denervation of the ear artery in vitro with 6-hydroxydopamine (6-OHDA). Dose-response curves to norepinephrine...

... agonist, clonidine, in concentrations (10 –6 M) which did likewise to the fractional release of 3 H-norepinephrine. Second, destruction of the adrenergic nerves by in vitro treatment with 6-hydroxydopamine reduced the fractional release of 3 H-purines by 55 %. The release of purines which remains after 6...

... greater in SHR compared to WKY vessels. Using either phentolamine or 6-hydroxydopamine-treated vessels to eliminate a neurogenic adrenergic response, we determined that a part of the HiK-induced contraction was due to NE released from nerve varicosities (i.e., the adrenergic component). In order...

.... 25 10 1976 7 01 1977 18 9 2008 Ouabain Membrane potential Sodium-potassium ATPase Electrogenic pump Norepinephrine 6-Hydroxydopamine Blood Vessels 14: 261-276 (1977) Mechanism of Potassium Relaxation of Arterial Muscle1 A . B o n a c c o r si, K. H erm sm eyer 2, O. A pr ig...

...Marvin Kaiman; Shoji Shibata 6-Hydroxydopamine (6-OHDA) increased the sensitivity of rat, rabbit and guinea pig portal veins to norepinephrine (NE), methoxamine (ME), barium (Ba ++ ) and calcium (Ca ++ ) but not to potassium (K + ). Reserpine potentiated the responses of NE, ME and Ca ++ but not Ba...

...Oliver Carrier, Jr.; Eberhard K. Wedell; Kirk W. Barron Specific desensitization of vascular tissue to norepinephrine was studied using an open-ring-type strip preparation of rabbit aorta. Aortae were taken from untreated, reserpine-pretreated (0.1 mg/kg/day; 3, 5, or 7 days) and 6-hydroxydopamine...