Hemodynamic shear stress is the frictional force of blood on the arterial wall. The shear pattern in the conduit artery affects the endothelium and may participate in the development and progression of atherosclerosis. We investigated the role of the shear pattern in age- and aerobic exercise-induced changes in conduit artery wall thickness via cross-sectional and interventional studies. In a cross-sectional study, we found that brachial shear rate patterns and brachial artery intima-media thickness (IMT) correlated with age. Additionally, brachial artery shear rate patterns were associated with brachial artery IMT in 102 middle-aged and older individuals. In an interventional study, 39 middle-aged and older subjects were divided into 2 groups: control and exercise. The exercise group completed 12 weeks of aerobic exercise training. Aerobic exercise training significantly increased the antegrade shear rate and decreased the retrograde shear rate and brachial artery IMT. Moreover, changes in the brachial artery antegrade shear rate and the retrograde shear rate correlated with the change in brachial artery IMT. The results of the present study indicate that changes in brachial artery shear rate patterns may contribute to age- and aerobic exercise training-induced changes in brachial artery wall thickness.

Keywords:
Shear pattern, Intima-media thickness, Aging, Aerobic exercise training
1.
Sorensen KE, Kristensen IB, Celermajer DS: Atherosclerosis in the human brachial artery. J Am Coll Cardiol 1997;29:318-322.
2.
Bjarnegård N, Länne T: Arterial properties along the upper arm in humans: age-related effects and the consequence of anatomical location. J Appl Physiol (1985) 2010;108:34-38.
3.
Nishiyama SK, Wray DW, Richardson RS: Aging affects vascular structure and function in a limb-specific manner. J Appl Physiol (1985) 2008;105:1661-70.
4.
Iwamoto Y, Maruhashi T, Fujii Y, Idei N, Fujimura N, Mikami S, et al: Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors. Arterioscler Thromb Vasc Biol 2012;32:2295-2303.
5.
Frick M, Suessenbacher A, Alber HF, Dichtl W, Ulmer H, Pachinger O, et al: Prognostic value of brachial artery endothelial function and wall thickness. J Am Coll Cardiol 2005;46:1006-1010.
6.
Hafner F, Kieninger A, Meinitzer A, Gary T, Froehlich H, Haas E, et al: Endothelial dysfunction and brachial intima-media thickness: long term cardiovascular risk with claudication related to peripheral arterial disease: a prospective analysis. PLoS One 2014;9: e93357.
7.
Green DJ, Swart A, Exterkate A, Naylor LH, Black MA, Cable NT, et al: Impact of age, sex and exercise on brachial and popliteal artery remodelling in humans. Atherosclerosis 2010;210:525-530.
8.
Maiorana AJ, Naylor LH, Exterkate A, Swart A, Thijssen DH, Lam K, et al: The impact of exercise training on conduit artery wall thickness and remodeling in chronic heart failure patients. Hypertension 2011;57:56-62.
9.
Wang JC, Bennett M: Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 2012;111:245-259.
10.
Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH: Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 2007;49:2379-2393.
11.
Tinken TM, Thijssen DH, Hopkins N, Dawson EA, Cable NT, Green DJ: Shear stress mediates endothelial adaptations to exercise training in humans. Hypertension 2010;55:312-318.
12.
Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, et al: Impact of shear rate modulation on vascular function in humans. Hypertension 2009;54:278-285.
13.
Naylor LH, Carter H, FitzSimons MG, Cable NT, Thijssen DH, Green DJ: Repeated increases in blood flow, independent of exercise, enhance conduit artery vasodilator function in humans. Am J Physiol Heart Circ Physiol 2011;300:H664-H669.
14.
Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ: Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension 2009;53:986-992.
15.
Schreuder TH, Green DJ, Hopman MT, Thijssen DH: Acute impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in humans. Physiol Rep 2014;2:e00193.
16.
Padilla J, Simmons GH, Fadel PJ, Laughlin MH, Joyner MJ, Casey DP: Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide. Hypertension 2011;57:484-489.
17.
Casey DP, Padilla J, Joyner MJ: α-Adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear. Hypertension 2012;60:1016-1022.
18.
Young CN, Deo SH, Padilla J, Laughlin MH, Fadel PJ: Pro-atherogenic shear rate patterns in the femoral artery of healthy older adults. Atherosclerosis 2010;211:390-392.
19.
Casey, DP, Schneider AC, Ueda K: Influence of chronic endurance exercise training on conduit artery retrograde and oscillatory shear in older adults. Eur J Appl Physiol 2016;116:1931-1940.
20.
Green D, Cheetham C, Reed C, Dembo L, O'Driscoll G: Assessment of brachial artery blood flow across the cardiac cycle: retrograde flows during cycle ergometry. J Appl Physiol (1985) 2002;93:361-368.
21.
Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R: Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986;74:1399-1406.
22.
Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA: Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. J Appl Physiol (1985) 2002;92:1458-1464.
23.
Forman DE, Berman AD, McCabe CH, Baim DS, Wei JY: PTCA in the elderly: the “young-old” versus the “old-old”. J Am Geriatr Soc 1992;40:19-22.
24.
Laughlin MH, Newcomer SC, Bender SB: Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype. J Appl Physiol (1985) 2008;104:588-600.
25.
Irace C, Carallo C, De Franceschi MS, Scicchitano F, Milano M, Tripolino C, et al: Human common carotid wall shear stress as a function of age and gender: a 12-year follow-up study. Age (Dordr) 2012;34:1553-1562.
26.
Birk GK, Dawson EA, Atkinson C, Haynes A, Cable NT, Thijssen DH, et al: Brachial artery adaptation to lower limb exercise training: role of shear stress. J Appl Physiol (1985) 2012;112:1653-1658.
27.
Thijssen DH, Schreuder TH, Newcomer SW, Laughlin MH, Hopman MT, Green DJ: Impact of 2-weeks continuous increase in retrograde shear stress on brachial artery vasomotor function in young and older men. J Am Heart Assoc 2015;4:e001968.
28.
Scholten RR, Spaanderman ME, Green DJ, Hopman MT, Thijssen DH: Retrograde shear rate in formerly preeclamptic and healthy women before and after exercise training: relationship with endothelial function. Am J Physiol Heart Circ Physiol 2014;307:H418-H425.
29.
Deanfield JE, Halcox JP, Rabelink TJ: Endothelial function and dysfunction: testing and clinical relevance. Circulation 2007;115:1285-1295.
30.
Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, et al: Additive beneficial effects of lactotripeptides intake with regular exercise on endothelium-dependent dilatation in postmenopausal women. Am J Hypertens 2010;23:368-372.
31.
Maeda S, Tanabe T, Otsuki T, Sugawara J, Iemitsu M, Miyauchi T, et al: Moderate regular exercise increases basal production of nitric oxide in elderly women. Hypertens Res 2004;27:947-953.
32.
Newcomer SC, Thijssen DH, Green DJ: Effects of exercise on endothelium and endothelium/smooth muscle cross talk: role of exercise-induced hemodynamics. J Appl Physiol (1985) 2011;111:311-320.
33.
Padilla J, Young CN, Simmons GH, Deo SH, Newcomer SC, Sullivan JP, et al: Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns. Am J Physiol Heart Circ Physiol 2010;298:H1128-H1135.
34.
Mueller PJ: Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity. Clin Exp Pharmacol Physiol 2007;34:377-384.
35.
Ng AV, Callister R, Johnson DG, Seals DR: Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans. J Appl Physiol 1994;77:1366-1374.
36.
Sugawara J, Komine H, Hayashi K, Yoshizawa M, Otsuki T, Shimojo N, et al: Systemic α-adrenergic and nitric oxide inhibition on basal limb blood flow: effects of endurance training in middle aged and older adults. Am J Physiol Heart Circ Physiol 2007;293:H1466-H1472.
37.
Thijssen DH, Scholten RR, van den Munckhof IC, Benda N, Green DJ, Hopman MT: Acute change in vascular tone alters intima-media thickness. Hypertension 2011;58:240-246.
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2017
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