The assembly of the vessel wall from its cellular and extracellular matrix components is a critical process in the development and maturation of the cardiovascular system. However, fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation remain unanswered. The initial step of vessel wall morphogenesis is formation of a primary vascular network, comprised of nascent endothelial cell tubes, via the processes of vasculogenesis and angiogenesis. Subsequently, primordial vascular smooth muscle cells (VSMCs) are recruited to the endothelium to form a multilayered vessel wall. During the course of development and maturation, the VSMC plays diverse roles: it is a biosynthetic, proliferative, and contractile component of the vessel wall. Although the field of vascular development has blossomed in the past decade, the molecules and mechanisms that regulate this developmental pathway are not well defined. The focus of this review is on those facets of VSMC development important for transforming a nascent endothelial tube into a multilayered structure. We discuss the primordial VSMC with particular attention to its purported origins, the components of the extracellular milieu that contribute to its development, and the contribution of embryonic hemodynamics to vessel wall assembly.

Keywords:
Vascular smooth muscle cell, Development, Differentiation, Extracellular matrix
1.
Noden D: Embryonic origins and assembly of blood vessels. Am Rev Respir Dis 1989;140:1097–1103.
2.
Thayer JM, Meyers K, Giachelli CM, Schwartz SM: Formation of the arterial media during vascular development. Cell Mol Biol Res 1995;41:251–262.
3.
Peault BM, Thiery J-P, Le Douarin NM: Surface marker for hemopoietic and endothelial cell lineages in quail that is defined by a monoclonal antibody. Proc Natl Acad Sci USA 1983;80:2976–2980.
4.
Pardanaud L, Altmann C, Kitos P, Dieterlen-Lievere F, Buck C: Vasculogenesis in the early quail blastodisc as studied with a monoclonal antibody recognizing endothelial cells. Development 1987;100:339–349.
5.
Coffin JD, Poole TJ: Embryonic vascular development: Immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia in quail embryos. Development 1988;102:735–748.
6.
Pardanaud L, Yassine F, Dieterlen-Lievre F: Relationship between vasculogenesis, angiogenesis and hemopoiesis during avian ontogeny. Development 1989;105:473–485.
7.
Poole TJ, Coffin JC: Vasculogenesis and angiogenesis: Two distinct morphogenetic mechanisms establish embryonic vascular pattern. J Exp Zool 1989;251:224–231.
8.
Baldwin HS: Early embryonic vascular development. Cardiovasc Res 1996;31:E34–E45.
9.
Risau W: Mechanisms of angiogenesis. Nature 1997;386:671–674.
10.
Drake CJ, Little CD: The morphogenesis of primordial vascular networks; in Little CD, Mironov V, Sage EH (eds): Vascular Morphogenesis: In vivo, in vitro, in mente. Boston, Birkhäuser, 1998, pp 3–20.
11.
Drake CJ, Hungerford JE, Little CD: Morphogenesis of the first blood vessels. Ann NY Acad Sci 1998;857:155–179.
12.
Wang HU, Chen Z-F, Anderson DJ: Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor EpH-B4. Cell 1998;93:741–753.
13.
Mecham RP, Stenmark KR, Parks WC: Connective tissue production by vascular smooth muscle in development and disease. Chest 1991;99:43S-47S.
14.
Tan EML, Glassberg E, Olsen DR, Noveral JP, Unger GA, Peltonen J, Chu M-L, Levine E, Sollberg S: Extracellular matrix gene expression by human endothelial and smooth muscle cells. Matrix 1991;11:380–387.
15.
Lee SH, Hungerford JE, Little CD, Iruela-Arispe ML: Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall. Dev Dyn 1997;209:342–352.
16.
Berne RM, Levy MN: Physiology, St. Louis, Mosby, 1988.
17.
Thyberg J, Hedin U, Sjölund M, Palmberg L, Bottger BA: Regulation of differentiated properties and proliferation of arterial smooth muscle cells. Arteriosclerosis 1990;10:966–990.
18.
Thyberg J: Differential properties and proliferation of arterial smooth muscle cells in culture. Int Rev Cytol 1996;169:183–265.
19.
Owens GK: Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 1995;75:487–517.
20.
Slack JMW: From Egg to Embryo: Regional Specification in Early Development. New York, Cambridge University Press, 1991.
21.
Gonzalez-Crussi F: Vasculogenesis in the chick embryo. An ultrastructural study. Am J Anat 1971;130:441–460.
22.
Karrer HE: Electron microscope study of developing chick embryo aorta. J Ultrastruct Res 1960;4:420–454.
23.
Kadar A, Gardner DL, Bush V: The relation between the fine structure of smooth-muscle cells and the elastogenesis in the chick-embryo aorta. J Pathol 1971;104:253–260.
24.
Manasek FJ: The ultrastructure of embryonic myocardial blood vessels. Dev Biol 1971;26:42–54.
25.
Nakamura H: Electron microscope study of the prenatal development of the thoracic aorta in the rat. Am J Anat 1988;181:406–418.
26.
Nikkari ST, Immo R, Pystynen P, Nikkari T: Characterization of the phenotype of smooth muscle cells in human fetal aorta on the basis of ultrastructure, immunofluorescence, and the composition of cytoskeletal and cytocontractile proteins. Atherosclerosis 1988;74:33–40.
27.
Kocher O, Skalli O, Cerutti D, Gabbiani F, Gabbiani G: Cytoskeletal features of rat aortic cells during development. Circ Rec 1985;56:829–838.
28.
Moss NS, Benditt EP: Spontaneous and experimentally induced arterial lesions. I. An ultrastructural survey of the normal chicken aorta. Lab Invest 1970;22:166–183.
29.
DeRuiter MC, Poelmann RE, VanMunsteren JC, Mironov V, Markwald RR, Gittenberger-de Groot AC: Embryonic endothelial cells transdifferentiate into mesenchymal cells expressing smooth muscle actins in vivo and in vitro. Circ Res 1997;80:444–451.
30.
Majesky MW, Schwartz SM: An origin for smooth muscle cells from endothelium? Circ Res 1997;80:601–603.
31.
Creazzo TL, Godt RE, Leatherbury L, Conway S, Kirby ML: Role of cardiac neural crest cells in cardiovascular development. Annu Rev Physiol 1998;60:267–286.
32.
Hunt P, Gulisano M, Cook M, Faiella A, Wilkinson D, Boncinelli E, Krumlauf R: A distinct Hox code for the branchial region of the head. Nature 1991;353:861–864.
33.
Kirby ML, Hunt P, Wallis K, Thorogood P: Abnormal patterning of the aortic arch arteries does not evoke cardiac malformations. Dev Dyn 1997;208:34–47.
34.
DeRuiter MC, Gittenberger de-Groot AC, Poelmann RE, van Iperen L, Mentink MMT: Development of the pharyngeal arch system related to the pulmonary and bronchial vessels in the avian embryo. Circulation 1993;87:1306–1319.
35.
Le Lièvre CS, Le Douarin NM: Mesenchymal derivatives of the neural crest: Analysis of chimeric quail and chick embryos. J. Embryol Exp Morphol 1975;34:125–154.
36.
Hamburger V, Hamilton HL: A series of normal stages in the development of the chick embryo. J Morphol 1951;88:49–92.
37.
Kirby ML: Role of extracardiac factors in heart development. Experientia 1988;44:944–951.
38.
Kirby ML, Waldo KL: Neural crest and cardiovascular patterning. Circ Res 1995;77:211–215.
39.
Rosenquist TH, Beall AC, Módis L, Fishman R: Impaired elastic matrix development in the great arteries after ablation of the cardiac neural crest. Anat Rec 1990;226:347–359.
40.
Bergwerff M, Verberne ME, DeRuiter MC, Poelmann RE, Gittenberger-de Groot: Neural crest cell contribution to the developing circulatory system: Implications for vascular morphology? Circ Res 1998;82:221–231.
41.
Fukiish Y, Morriss-Kay GM: Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos. Cell Tissue Res 1992;268:1–8.
42.
Conway SJ, Henderson DJ, Copp AJ: Pax 3 is required for cardiac neural crest migration in the mouse: Evidence from Splotch (Sp2H) mutant. Development 1994;124:505–514.
43.
Bergwerff M, DeRuiter MC, Poelmann RE, Gittenberger-de Groot AC: Onset of elastogenesis and down regulation of smooth muscle actin as dinstinguishing phenomena in artery differentiation in chick embryos. Anat Embryol 1996;194:545–557.
44.
Gadson PF, Rossignol C, McCoy J, Rosenquist TH: Expression of elastin, smooth muscle alpha-actin, and c-Jun as a function of the embryonic lineage of vascular smooth muscle cells. In vitro Cell Dev Biol 1993;29A:773–781.
45.
Topouzis S, Majesky MW: Smooth muscle lineage diversity in the chick embryo: Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-β. Dev Biol 1996;178:430–445.
46.
Yanagisawa H, Hammer RE, Richardson JA, Williams SC, Clouthier DE, Yanagisawa M: Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J Clin Invest 1998;102:22–33.
47.
Fishman KC, Kirby ML: Fallen arches, or how the embryo got its head. J Clin Invest 1998;102:1–3.
48.
Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T, Kumada M, Hammer RE, Yanagisawa M: Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 1998;125:813–824.
49.
Kurihara Y, Kurihara H, Oda H, Maemura K, Nagai R, Ihikawa T, Yazaki Y: Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 1995;96:293–300.
50.
Yanagisawa H, Yanagisawa M, Kapur RP, Richardson JA, Williams SC, Clouthier DE, de Wit D, Emoto N, Hammer RE: Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development 1998;125:825–836.
51.
Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D: A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 1998;125:3005–3014.
52.
Tomanek RJ: Formation of the coronary vasculature: A brief review. Cardiovasc Res 1996;31:E46–E51.
53.
Poelmann RE, Gittenberger de-Groot AC, Mentink MMT, Bökenkamp R, Hogers B: Development of the cardiac coronary vascular endothelium, studied with antiendothelial antibodies, in chicken-quail chimeras. Circ Res 1993;73:559–568.
54.
Mikawa T, Fischman DA: Retroviral analysis of cardiac morphogenesis: Discontinuous formation of coronary vessels. Proc Natl Acad Sci USA 1992;89:9504–9508.
55.
Mikawa T, Gourdie RG: Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol 1996;174:221–232.
56.
Dettman RW, Denetclaw W, Ordahl CP, Bristow J: Common epicardial origin of coronary vascular smooth muscle, t fibroblasts, and intermyocardial fibroblasts in the avian heart. Dev Biol 1998;193:169–181.
57.
Vrancken Peeters M-PFM, Gittenberger-de Groot AC, Mentink MMT, Hungerford JE, Little CD, Poelmann RE: The development of the coronary vessels and their differentiation into arteries and veins in the embryonic quail heart. Dev Dyn 1997;208:338–348.
58.
Hungerford JE, Owens GK, Argraves WS, Little CD: Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers. Dev Biol 1996;178:375–392.
59.
Williams SK: Endothelial cell transplantation. Cell Transplant 1995;4:401–410.
60.
Williams SK, Carter T, Park PK, Rose DG, Scheider T, Jarrell BE: Formation of a multilayer cellular lining on a polyurethane vascular graft following endothelial cell sodding. J Biomed Mater Res 1992;26:103–117.
61.
Williams SK, Kleinart LB, Rose D, McKenney S: Origin of endothelial cells that line expanded polytetrafluoroethylene vascular grafts sodded with cells from microvascularized fat. J Vasc Surg 1994;19:594–604.
62.
Williams SK, Rose DG, Jarrell BE: Microvascular endothelial cell sodding of ePTFE vascular grafts: Improved patency and stability of the cellular lining. J Biomed Mater Res 1994;28:203–212.
63.
Arciniegas E, Sutto AB, Allen TD, Schor AM: Transforming growth factor beta 1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro. J Cell Sci 1992;103:521–529.
64.
Tuder RM, Groves B, Badesch DB, Voekel NF: Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 1994;144:275–285.
65.
Gilbert SF: Developmental Biology. Sunderland, Sinauer, 1988.
66.
Jacobson AG, Sater AK: Features of embryonic induction. Development 1988;104:341–359.
67.
Flamme I: Is extraembryonic angiogenesis in the chick embryo controlled by the endoderm? Anat Embryol 1989;180:259–272.
68.
Sugi Y, Lough J: Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region. Dev Dyn 1994;200:155–162.
69.
Hirschi KK, D’Amore PA: In vitro coculture models to study vessel formation and function; in Little CD, Mironov V, Sage EH (eds): Vascular Morphogenesis: In Vivo, In Vitro, In Mente. Boston, Birkhäuser, 1998, pp 131–140.
70.
Watterson RL, Fowler I, Fowler BJ: The role of the neural tube and notochord in development of the axial skeleton of the chick. Am J Anat 1954;95:337–399.
71.
Placzek M, Tessier-Lavigne M, Yamada T, Jessell T, Dodd J: Mesodermal control of neural cell identity: Floor plate induction by the notochord. Science 1990;250:985–988.
72.
Newgreen DF, Scheel M, Kastner V: Morphogenesis of sclerotome and neural crest in avian embryos. Cell Tissue Res 1986;244:299–313.
73.
Tosney KW, Oakley RA: The perinotochordal mesenchyme acts as a barrier to axon advance in the chick embryo: Implications for a general mechanism of axonal guidance. Exp Neurol 1990;109:75–89.
74.
Talbot WS, Trevarrow B, Halpern ME, Melby AE, Farr G, Postlethwait JH, Jowett T, Kimmel CB, Kimelman D: A homeobox gene essential for zebrafish notochord development. Nature 1995;378:150–157.
75.
Schulte-Merker S, van Eeden FJM, Halpern ME, Kimmel CB, Nüsslein-Volhard C: No tail (ntl) is the zebrafish homologue for the mouse T (Brachyury) gene. Development 1994;120:1009–1015.
76.
Fouquet B, Weinstein BM, Serluca FC, Fishman MC: Vessel patterning in the embryo of the zebrafish: Guidance by notochord. Dev Biol 1997;183:37–48.
77.
Sumoy L, Keasey JB, Dittman TD, Kimelman D: A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGFR-2 in zebrafish flh and ntl mutant embryos. Mech Dev 1997;63:15–27.
78.
Olson EN: Regulation of muscle transcription by the MyoD family. Circ Res 1993;72:1–6.
79.
Olson EN: Signal transduction pathways that regulate skeletal muscle gene expression. Mol Endocrinol 1993;7:1369–1378.
80.
Emerson CPJ: Embryonic signals for skeletal myogenesis: Arriving at the beginning. Curr Opin Cell Biol 1993;5:1057–1064.
81.
Ontell M, Ontell MP, Buckingham M: Muscle-specific gene expression during myogenesis in the mouse. Microsc Res Tech 1995;30:354–365.
82.
Garrels JI, Gibson W: Identification and characterization of multiple forms of actin. Cell 1976;9:793–805.
83.
Gabbiani G, Schmid E, Winter S, Chaponnier C, De Chastonay C, Vandekerckhove J, Weber K, Franke WW: Vascular smooth muscle cells differ from other smooth muscle cells: Predominance of vimentin filaments and a specific α-type actin. Proc Natl Acad Sci USA 1981;78:298–302.
84.
Fatigati V, Murphy RA: Actin and tropomyosin variants in smooth muscles. Dependence on tissue type. J Biol Chem 1984;259:14383–24388.
85.
Owens GK, Thompson MM: Developmental changes in isoactin expression in rat aortic smooth muscle cells in vivo. J Biol Chem 1986;261:13373–13380.
86.
Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G: A monoclonal antibody against α-smooth muscle actin: A new probe for smooth muscle differentiation. J Cell Biol 1986;103:2787–2796.
87.
Glukhova MA, Kabakov AE, Frid MG, Ornatsky OI, Belkin AM, Mukhin DN, Orekhov AN, Koteliansky VE, Smirnov VN: Modulation of human aorta smooth muscle cell phenotype: A study of muscle-specific variants of vinculin, caldesmon, and actin expression. Proc Natl Acad Sci USA 1988;85:9542–9546.
88.
Glukhova MA, Frid MG, Koteliansky VE: Developmental changes in expression of contractile and cytoskeletal proteins in human aortic smooth muscle. J Biol Chem 1990;265:13042–13046.
89.
DeRuiter MC, Poelmann RE, van Iperen L, Gittenberger-de Groot AC: The early development of the tunica media in the vascular system of rat embryos. Anat Embryol 1990;181:341–349.
90.
Ruzicka DL, Schwartz RJ: Sequential activation of α-actin genes during avian cardiogenesis: Vascular smooth muscle α-actin gene transcripts mark the onset of cardiomyocyte differentiation. J Cell Biol 1988;107:2575–2586.
91.
Sawtell NM, Lessard JL: Cellular distribution of smooth muscle actins during mammalian embryogenesis: Expression of the α-vascular but not the α-enteric isoform in differentiating striated myocytes. J Cell Biol 1989;109:2929–2937.
92.
Sugi Y, Lough J: Onset of expression and regional deposition of alpha-smooth and sarcomeric actin during avian heart development. Dev Dyn 1992;193:116–124.
93.
Saint-Jeannet J-P, Levi G, Girault J-M, Koteliansky V, Thiery J-P: Ventrolateral regionalization of Xenopus laevis mesoderm is characterized by the expression of α-smooth muscle actin. Development 1992;115:1165–1173.
94.
Saint-Jeannet J-P, Thiery JP, Koteliansky VE: Effect of an inhibitory mutant of the FGF receptor on mesodern-derived alpha-smooth muscle actin-expressin cells. Dev Biol 1994;164:374–382.
95.
Skalli O, Pelte M-F, Peclet M-C, Gabbiani G, Gugliotta P, Bussolati G, Ravazzola M, Orci L: α-Smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J Histochem Cytochem 1989;37:315–321.
96.
Skalli O, Vandekerckhove J, Gabbiani G: Actin-isoform pattern as a marker of normal or pathological smooth-muscle and fibroblastic tissues. Differentiation 1987;33:232–238.
97.
Rønnov-Jessen L, van Deurs B, Celis JE, Petersen OW: Smooth muscle differentiation in cultured human breast gland stromal cells. Lab Invest 1990;63:532–543.
98.
Jahoda CAB, Reynolds AJ, Chaponnier C, Forester JC, Gabbiani G: Smooth muscle α-actin is a marker for hair follicle dermis in vivo and in vitro. J Cell Sci 1991;99:627–636.
99.
Lazard D, Sastre X, Frid MG, lukhova MA, Thiery J-P, Koteliansky VE: Expression of smooth muscle specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci USA 1993;90:999–1003.
100.
Duband J-l, Gimona M, Scatena M, Sartore S, Small JV: Calponin and SM22 as differentiation markers of smooth muscle: Spatiotemporal distribution during avian embryonic development. Differentiation 1993;55:1–11.
101.
Kuro-o M, Nagai R, Tsuchimochi H, Katoh H, Yazaki Y, Ohkubo A, Takaku F: Developmentally regulated expression of vascular smooth muscle myosin heavy chain isoforms. J Biol Chem 1989;164:18272–18275.
102.
Borrione AC, Zanellato AMC, Scannapieco G, Pauletto P, Sartore S: Myosin heavy-chain isoforms in adult and developing rabbit smooth muscle. Eur J Biochem 1989;183:413–417.
103.
Aikawa M, Sivam PN, Kuro-o M, Kimura K, Nakahara K-I, Takewaki S-I, Ueda M, Yamaguchi H, Yazaki Y, Periasamy M, Nagai R: Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res 1993;73:1000–1012.
104.
Colbert MC, Kirby ML, Robbins J: Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus. Circ Res 1996;78:790–798.
105.
Miano JM, Cserjesi P, Ligon KL, Periasamy M, Olson EN: Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis. Circ Res 1994;75:803–812.
106.
Li L, Miano JM, Mercer B, Olson EN: Expression of the SM22α promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J Cell Biol 1996;132:849–859.
107.
Miano JM, Olson EN: Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis. J Biol Chem 1996;271:7095–7103.
108.
Samaha FF, Ip HS, Morrisey EE, Seltzer J, Tang Z, Solway J, Parmacek MS: Developmental pattern of expression and genomic organization of the calponin-h1 gene: A contractile smooth muscle cell marker. J Biol Chem 1996;271:395–403.
109.
Frid MG, Shekhonin BV, Koteliansky VE, Glukhova MA: Phenotypic changes of human smooth muscle cells during development: Late expression of heavy caldesmon and calponin. Dev Biol 1992;153:185–193.
110.
Hungerford JE: Development of the vessel wall; thesis; University of Virginia, Charlottesville, 1995.
111.
Chaponnier C, Kocher O, Gabbiani G: Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture. Eur J Biochem 1990;190:559–565.
112.
Turner CE: Paxillin is a major phosphotyrosine-containing protein during embryonic development. J Cell Biol 1991;115:201–207.
113.
Nanaev AK, Shirinsky VP, Birukov KG: Immunofluorescent study of heterogeneity in smooth muscle cells of human fetal vessels using antibodies to myosin, desmin, and vimentin. Cell Tissue Res 1991;266:535–540.
114.
Weitzer G, Milner DJ, Kim JU, Bradley A, Capetanaki Y: Cytoskeletal control of myogenesis: A desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation. Dev Biol 1995;172:422–439.
115.
Capetanaki Y, Milner DJ, Weitzer G: Desmin in muscle formation and maintenance: Knockouts and consequences. Cell Struct Funct 1997;22:103–116.
116.
Li Z, Colucci-Guyon E, Pincon-Raymond M, Mericskay M, Pournin S, Paulin D, Babinet C: Cardiovascular lesions and skeletal myopathy in mice lacking desmin. Dev Biol 1996;175:362–366.
117.
Li ZL, Mericskay M, Agbulut O, Butlerbrowne G, Carlsson L, Thornell LE, Babinet C, Paulin D: Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. J Cell Biol 1997;139:129–144.
118.
Milner DJ, Weitzer G, Tran D, Bradley A, Capetanaki Y: Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol 1996;134:1255–1270.
119.
Kuisk IR, Li H, Tran D, Capetanaki Y: A single MEF2 site governs desmin transcription in both heart and skeletal muscle during embryogenesis. Dev Biol 1996;174:1–13.
120.
Galou M, Gao J, Humbert J, Mericskay M, Li ZL, Paulin D, Vicart P: The importance of intermediate filaments in the adaptation of tissues to mechanical stress-evidence from gene knockout studies. Biol Cell 1997;89:85–97.
121.
Henrion D, Terzi F, Matrougui K, Duriez M, Boulanger CM, Colucci-Guyon E, Babinet C, Briand P, Friedlander G, Poitevin P, Levy BI: Impaired flow-induced dilatation in mesenteric resistance arteries from mice lacking vitamin. J Clin Invest 1997;100:2909–2914.
122.
van der Loop FTL, Schaart G, Timmer EDJ, Ramaekers FCS, van Eys GJJM: Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. J Cell Biol 1996;134:401–411.
123.
Wehrens XH, Mies B, Gimona M, Ramaekers FC, van Eys GJ, Small JV: Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform. FEBS Lett 1997;405:315–320.
124.
van der Loop FTL, Gabbiani G, Kohnen G, Rameaker FC, van Eys GJ: Differentiation of smooth muscle cells in human blood vessels as defined by smoothelin, a novel marker for the contractile phenotype. Arterioscler Thromb Vasc Biol 1997;17:665–671.
125.
Herring BP, Smith AF: Telokin expression is mediated by a smooth muscle cell-specific promoter. Am J Physiol 1996;270:C1656–C1665.
126.
Herring BP, Smith AF: Telokin expression in A10 smooth muscle cells requires serum response factor. Am J Physiol 1997;272:C1394–C1404.
127.
Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kahiki L, Lee WS, Perella MA, Haber E, Lee ME: Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. J Biol Chem 1996;271:10194–10199.
128.
Hsieh CM, Yoshizumi M, Endege WO, Kho CJ, Jain MK, Kashiki S, de los Santos R, Lee WS, Perella MA, Lee ME: APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem 1996;271:17354–17359.
129.
Hungerford JE, Hoeffler JP, Bowers CW, Dahm LM, Falchetto R, Shabanowitz J, Hunt DF, Little CD: Identification of a novel marker for primordial smooth muscle and its differential expression pattern in contractile vs noncontractile cells. J Cell Biol 1997;137:925–937.
130.
Endo T, Masaki T: Molecular properties and functions in vitro of chicken smooth-muscle α-actinin in comparison with those of striated-muscle α-actinins. J Biochem (Tokyo) 1982;92:1457–1468.
131.
Duband J-L, Thierry JP: Spatio-temporal distribution of the adherens junction-associated molecules vinculin and talin in the early avian embryo. Cell Differ Dev 1990;30:55–76.
132.
Buck CA, Horwitz AF: Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol 1987;3:179–205.
133.
Geiger B, Ayalon O: Cadherins. Annu Rev Cell Biol 1992;8:307–332.
134.
DeSimone DW: Adhesion and matrix in vertebrate development. Curr Opin Cell Biol 1994;6:747–751.
135.
Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11–25.
136.
Clark EA, Bruggs JS: Integrins and signal transduction pathways: The road taken. Science 1995;268:233–239.
137.
Strömblad S, Cheresh DA: Cell adhesion and angiogenesis. Trends Cell Biol 1996;6:462–467.
138.
Hynes RO, Bader BL: Targeted mutations in integrins and their ligands: Their implications form vascular biology. Thromb Haematol 1997;78:83–87.
139.
Hynes RO, Wagner DD: Genetic manipulation of vascular adhesion molecules in mice. J Clin Invest 1997;100:S11–S13.
140.
Bottger BA, Hedin U, Johansson S, Thyberg J: Integrin-type fibronectin receptors of rat arterial smooth muscle cells: Isolation, partial characterization and role in cytoskeletal organization and control of differential properties. Differentiation 1989;41:158–167.
141.
Clyman RI, McDonald KA, Kramer RH: Integrin receptors on aortic smooth muscle cells mediate adhesion to fibronectin, laminin, and collagen. Circ Res 1990;67:175–186.
142.
Belkin VM, Belkin AM, Koteliansky VE: Human smooth muscle VLA-1 integrin: Purification, substrate specificity, localization in aorta, and expression during development. J Cell Biol 1990;111:2159–2170.
143.
Koteliansky VE, Belkin AM, Frid MG, Glukhova M: Developmental changes in expression of adhesion-mediating proteins in human aortic smooth muscle. Biochem Soc Trans 1991;19:1072–1076.
144.
Duband J-L, Belkin AM, Syfrig J, Thiery JP, Koteliansky VE: Expression of α1 integrin, a laminin-collagen receptor, during myogenesis and neurogenesis in the avian embryo. Development 1992;116:585–600.
145.
Shepard AM, Onken MD, Rosen GD, Noakes PG, Dean DC: Expanding roles for α4 integrin and its ligands in development. Cell Adhes Commun 1994;2:27–43.
146.
Wang A, Patrone L, McDonald JA, Sheppard D: Expression of the integrin subunit α9 in the murine embryo. Dev Dyn 1995;204:421–431.
147.
Schnapp LM, Breuss J, Ramos DM, Sheppard D, Pytela R: Sequence and tissue distribution of the human integrin α8 subunit: A β1-associated α subunit expressed in smooth muscle cells. J Cell Sci 1995;108:537–544.
148.
Velling T, Collo G, Sorokin L, Durbeej M, Zhang H, Gullberg D: Distinct α7Aβ1 and α7Bβ1 integrin expression patterns during mouse development: α7A is restricted to skeletal muscle but α7B is expressed in striated muscle, vasculature, and nervous system. Dev Dyn 1996;207:355–371.
149.
Cremona O, Savoia P, Marchisio PC, Gabbiani G, Chaponnier C: The α6 and β4 integrin subunits are expressed by smooth muscle cells of human small vessels: A new localization in mesenchymal cells. J Histochem Cytochem 1994;42:1221–1228.
150.
Dejana E, Corada M, Lampugnani MG: Endothelial cell-to-cell junctions. FASEB J 1995;9:910–918.
151.
Gulbenkian S, Santos J, Gordon L, Wharton J, Polock JM, David-Ferreira F: Neural cell adhesion molecule is expressed by smooth muscle cells during the development of the rat vascular system. J Neurocytol 1989;18:809–817.
152.
Couffinhal T, Duplaa C, Moreau C, Lamaziere J-MD, Bonnet J: Regulation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular smooth muscle cells. Circ Res 1994;74:225–234.
153.
Duplàa C, Couffinhal T, Dufourcq P, Llanas B, Moreau C, Bonnet J: The integrin very late antigen-4 is expressed in human smooth muscle cell: Involvement of α4 and vascular cell adhesion molecule-1 during smooth muscle cell differentiation. Circ Res 1997;80:159–169.
154.
Gilbertson-Beadling SK, Fisher C: A potential role for N-cadherin in mediating endothelial cell-smooth muscle cell interactions in the rat vasculature. Lab Invest 1993;69:203–209.
155.
Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO: Developmental defects in mouse embryos lacking N-cadherin. 1997;181:64–78.
156.
Christ GJ, Spray DC, El-Sabban M, Moore LK, Brink PR: Gap junctions in vascular tissues. Evaluation the role of intercellular communication in the modulation of vasomotor tone. Circ Res 1996;79:631–646.
157.
Blackburn JP, Connat J-L, Severs NJ, Green CR: Connexin 43 gap junction levels during development of the thoracic aorta are temporally correlated with elastic laminae deposition and increased blood pressure. Cell Biol Int 1997;21:87–97.
158.
Shimizu RT, Blank RS, Jervis R, Lawrenz-Smith SC, Owens GK: The smooth muscle α-actin gene promoter is differentially regulated in smooth muscle versus nonmuscle cells. J Biol Chem 1995;270:7631–7643.
159.
Kallmeier RC, Somasudaram C, Babiji P: A novel smooth muscle-specific enhancer regulates transcription of the smooth muscle myosin heavy chain gene in vascular smooth mus- cle cells. J Biol Chem 1995;270:30949–30957.
160.
White SL, Low RB: Identification of promoter elements involved in cell-specific regulation of rat smooth muscle myosin heavy chain gene transcription. J Biol Chem 1996;271:15008–15017.
161.
Madsen CS, Regan CP, Owens GK: Interaction of CARG elements and a GC-rich repressor element in transcriptional regulation of the smooth muscle myosin heavy chain gene in vascular smooth muscle cells. J Biol Chem 1997;272:29842–29851.
162.
Zilberman A, Dave V, Miano J, Olson EN, Periasamy M: Evolutionarily conserved promoter region containing CarG*-like elements is crucial for smooth muscle myosin heavy chain expression. Circ Res 1998;82:566–575.
163.
Madsen CS, Regan CP, Hungerford JE, White SL, Manabe I, Owens GK: Smooth muscle-specific expression of the smooth muscle myosin heavy chain gene in transgenic mice requires 5′-flanking and first intronic DNA sequence. Circ Res 1998;82:908–917.
164.
Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN: Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 1997;16:154–160.
165.
Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM: Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells. Proc Natl Acad Sci USA 1996;93:900–905.
166.
Hautmann MB, Thompson MM, Swartz EA, Olson EN, Owens GK: Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHOX. Circ Res 1997;81:600–610.
167.
Bergwerff M, Gittenberger-de Groot AC, DeRuiter MC, van Iperen L, Meijlink F, Poelmann RE: Patterns of paired-related homeobox genes PRX1 and PRX2 suggest involvement in matrix modulation in the developing chick vascular system. Dev Dyn 1998;213:59–70.
168.
Morrisey EE, Ip HS, Lu MM, Parmacek MS: GATA-6: A zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 1996;177:309–322.
169.
Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS: GATA-5: A transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol 1997;183:21–36.
170.
Lilly B, Zhao B, Ranganyakulu G, Paterson BM, Schulz RA, Olsen EN: Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 1995;267:688–693.
171.
Olson EN, Perry M, Schulz RA: Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. Dev Biol 1995;172:2–14.
172.
Blank RS, McQuinn TC, Yin KC, Thompson MM, Takeyasu K, Schwartz RJ, Owens GK: Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation. J Biol Chem 1992;267:984–989.
173.
Kim S, Ip HS, Min ML, Clendenin C, Parmacek MS: A serum response factor dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol Cell Biol 1997;17:2266–2278.
174.
Li L, Liu Z-C, Mercer B, Overbeek P, Olson EN: Evidence for serum response factor-mediated regulatory networks governing SM22α transcription in smooth, skeletal, and cardiac muscle cells. Dev Biol 1997;187:311–321.
175.
Browning CL, Culberson DE, Aragon IV, Fillmore RA, Croissant JD, Schwartz RJ, Zimmer WE: The developmentally regulated expression of serum response factor plays a key role in the control of smooth muscle-specific genes. Dev Biol 1998;194:18–37.
176.
Kuo CT, Veselits ML, Barton KP, Lu MM, Clendenin C, Leiden JM: The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev 1997;11:2996–3006.
177.
Grant DS, Tashiro K-I, Segui-Real B, Yamada Y, Martin GR, Kleinman HK: Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro. Cell 1989;58:933–943.
178.
Flamme I, Baranowski A, Risau W: A new model of vasculogenesis and angiogenesis in vitro as compared with vascular growth in the avian area vasculosa. Anat Rec 1993;237:49–57.
179.
Vernon RB, Lara SL, Drake CJ, Iruela-Arispe ML, Angello JC, Little CD, Wight TN, Sage EH: Organized type I collagen influences endothelial patterns during ‘spontaneous angiogenesis in vitro’: Planar cultures as models of vascular development. In Vitro Cell Dev Biol 1995;31:120–131.
180.
Hirschi KK, Rohovsky SA, D’Amore PA: PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol 1998;141:805–814.
181.
Chamley-Campbell JH, Campbell G, Ross R: Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens. J Cell Biol 1981;89:379–383.
182.
Campbell JH, Campbell GR: Endothelial cell influences on vascular smooth muscle phenotype. Annu Rev Physiol 1986;48:295–306.
183.
Pauley RR, Passaniti A, Crow M, Kinsella JL, Papadopoulos N, Monticone R, Lakatta EG, Martin GR: Experimental models that mimic the differentiation and dedifferentiation of vascular cells. Circulation 1992;86(SIII):III68–III73.
184.
Bowers CW, Dahm LA: Maintenance of contractility in dissociated smooth muscle: Low density cultures in defined medium. Am J Physiol 1993;264:C229–C236.
185.
Dahm LM, Bowers CW: Vitronectin regulates smooth muscle contractility via αv and β1 integrin(s). J Cell Sci 1998;111:1175–1183.
186.
Rao RS, Miano JM, Olson EN, Seidel CL: The A10 cell line: A model for neonatal, neointimal, or differentiated vascular smooth muscle cells? Cardiovasc Res 1997;36:118–126.
187.
Rudnicki MA, Sawtell NM, Reuhl KR, Berg R, Craig JC, Jardine K, Lessard JL, McBurney MW: Smooth muscle actin expression during P19 embryonal carcinoma differentiation in cell culture. J Cell Physiol 1990;142:89–98.
188.
Blank RS, Swartz EA, Thompson MM, Olson EN, Owens GK: A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics. Cir Res 1995;76:742–749.
189.
Suzuki T, Kim H-S, Kurabayashi M, Hamada H, Fujii H, Aikawa M, Watanabe M, Watanabe N, Sakomra Y, Yazaki Y, Nagai R: Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2. Circ Res 1996;78:395–404.
190.
Topouzis S, Catravas JD, Ryan JW, Rosenquist TH: Influence of vascular smooth muscle heterogeneity on angiotensin converting enzyme activity in chicken embryonic aorta and in endothelial cells in culture. Circ Res 1992;71:923–931.
191.
Wrenn RW, Raeuber CL, Herman LE, Walton WJ, Rosenquist TH: Transforming growth factor-beta: Signal transduction via protein kinase C in cultured embryonic vascular smooth muscle cells. In Vitro Cell Dev Biol 1993;29A:73–78.
192.
Theiszen SL, Dalton M, Gadson PF, Patterson E, Rosenquist TH: Embryonic lineage of vascular smooth muscle cells determines responses to collagen matrices and integrin receptor expression. Exp Cell Res 1996;227:135–145.
193.
Cook CL, Weiser MCM, Schwartz PE, Jones CL, Majack RA: Developmentally timed expression of an embryonic growth phenotype in vascular smooth muscle cells. Circ Res 1994;74:189–196.
194.
Han DKM, Liau G: Identification and characterization of developmentally regulated genes in vascular smooth muscle. Circ Res 1992;71:711–719.
195.
Shanahan CM, Weissberg PL, Metcalfe JC: Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Circ Res 1993;73:193–204.
196.
Lemire JM, Covin CW, White S, Giachelli CM, Schwartz SM: Characterization of cloned aortic smooth muscle cells from young rats. Am J Pathol 1994;144:1068–1081.
197.
Betz E, Fallier-Becker P, Wolburg-Buchholz K, Fotev Z: Proliferation of smooth muscle cells in the inner and outer layers of the tunica media of arteries: An in vitro study. J Cell Physiol 1991;147:385–395.
198.
Saunders KB, D’Amore PA: An in vitro model for cell-cell interactions. In Vitro Cell Dev Biol 1992;28A:521–528.
199.
Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R: The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands, and myocardium. J Embryol Exp Morphol 1985;87:27–45.
200.
Risau W, Sariola H, Zerwes H-G, Sasse J, Ekblom P, Kemler R, Doetschman T: Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development 1988;102:471–478.
201.
Wang R, Clark R, Bautch V: Embryonic stem cell-derived embryoid bodies form vascular channels: An in vitro model of blood vessel development. Development 1992;114:303–316.
202.
Doetschman TC, Shull M, Kier A, Coffin JD: Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders. Hypertension 1993;22:618–629.
203.
Krah K, Mironov V, Risau W, Flamme I: Induction of vasculogenesis in quail blastodisc-derived embryoid bodies. Dev Biol 1994;164:123–132.
204.
Ng WA, Doetschman T, Robbins J, Lessard JL: Muscle isoactin expression during in vitro differentiation of murine embryonic stem cells. Pediatr Res 1997;41:285–292.
205.
Drab M, Haller H, Bychkov R, Erdmann B, Lindschau C, Haase H, Morano I, Luft FC, Wobus AM: From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: A retinoic acid and db-cAMP in vitro differentiation model. FASEB J 1997;11:905–915.
206.
Blau HM, Baltimore D: Differentiation requires continuous regulation. J Cell Biol 1991;112:781–783.
207.
Bissell MJ, Hall HG, Parry G: How does the extracellular matrix direct gene expression? J Theor Biol 1982;99:31–68.
208.
Adams JA, Watt FM: Regulation of development and differentiation by the extracellular matrix. Development 1993;117:1183–1198.
209.
Davidson J, Hill KE, Mason ML, Giro MG: Longitudinal gradients of collagen and elastin gene expression in the porcine aorta. J Biol Chem 1985;260:1901–1908.
210.
Carey DJ: Control of growth and differentiation of vascular cells by extracellular matrix proteins. Annu Rev Physiol 1991;53:161–177.
211.
Madri JA, Bell L, Marx M, Merwin JR, Basson C, Prinz C: Effects of soluble factors and extracellular matrix components on vascular cell behavior in vitro and in vivo: Models of deendothelialization and repair. J Cell Biol 1991;45:123–130.
212.
Vernon RB, Sage EH: Between molecules and morphology: Extracellular matrix and creation of vascular form. Am J Pathol 1995;147:873–882.
213.
Schnieke A, Harbers K, Jaenisch R: Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene. Nature 1983:304:315–320.
214.
Lohler J, Timpl R, Jaenisch R: Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death. Cell 1984;38:597–607.
215.
George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO: Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 1993;119:1079–1091.
216.
Murphy ME, Carlson EC: An ultrastructural study of developing extracellular matrix in vitelline blood vessels of the early chick embryo. Am J Anat 1978;151:345–376.
217.
Risau W, Lemmon V: Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev Biol 1988;125:441–450.
218.
Handler M, Yurchenco PD, Iozzo RV: Developmental expression of perlecan during murine embryogenesis. Dev Dyn 1997;210:130–145.
219.
Forsten KE, Courant NA, Nugent MA: Endothelial proteoglycans inhibit bFGF binding and mitogenesis. J Cell Physiol 1997;172:209–220.
220.
Weiser MC, Belknap JK, Grieshaber SS, Kinsella MG, Majack RA: Developmental regulation of perlecan gene expression in aortic smooth muscle cells. Matrix Biol 1996;15:331–340.
221.
Weiser MC, Grieshaber NA, Schwartz PE, Majack RA: Perlecan regulates Oct-1 gene expression in vascular smooth muscle cells. Mol Biol Cell 1997;8:999–1011.
222.
Rosenquist TH, McCoy JR, Waldo KL, Kirby ML: Origin and propagation of elastogenesis in the developing cardiovascular system. Anat Rec 1988;221:860–871.
223.
Rosenquist TH, Beall AC: Elastogenic cells in the developing cardiovascular system. Ann NY Acad Sci 1990;588:106–119.
224.
Wolfe BL, Rich CB, Goud HD, Terpstra AJ, Bashir M, Rosenbloom J, Sonenshein GE, Foster JA: Insulin-like growth factor-I regulates transcription of the elastin gene. J Biol Chem 1993;268:12418–12426.
225.
Rich CB, Goud HD, Bashir M, Rosenbloom J, Foster JA: Developmental regulation of aortic elastin gene expression involves disruption of an IGF-I sensitive repressor complex. Biochem Biophys Res Commun 1993;196:1316–1322.
226.
Perrin S, Foster JA: Developmental regulation of elastin gene expression. Crit Rev Eukaryot Gene Expr 1997;7:1–10.
227.
Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, Keating MT: Elastin is an essential determinant of arterial morphogenesis. Nature 1998;393:276–280.
228.
Little CD, Rongish BJ: The extracellular matrix during heart development. Experientia 1995;51:873–882.
229.
Roark EF, Keene DR, Haudenschild CC, Godyna S, Little CD, Argraves WS: The association of human fibulin-1 with elastic fibers: An immunohistological, ultrastructural, and RNA study. J Histochem Cytochem 1995;43:401–411.
230.
Spence SG, Argraves WS, Walters L, Hungerford JE, Little CD: Fibulin is localized at sites of epithelial-mesenchymal transitions in the early avian embryo. Dev Biol 1992;151:473–484.
231.
Zhang H-Y, Timpl R, Sasaki T, Chu M-L, Ekblom P: Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo. Dev Dyn 1996;205:348–364.
232.
Gallagher BC, Sakai LX, Little CD: Fibrillin delineates the primary axis of the early avian embryo. Dev Dyn 1993;196:70–78.
233.
Rongish BJ, Drake CJ, Argraves WS, Little CD: Identification of the developmental marker, JB3-antigen, as fibrillin-2 and its de novo organization into embryonic microfibrous arrays. Dev Dyn 1998;12:461–471.
234.
Wunsch AM, Little CD, Markwald RR: Cardiac endothelial heterogeneity defines valvular development as demonstrated by the diverse expression of JB3, an antigen of the endocardial cushion tissue. Dev Biol 1994;165:85601.
235.
Bouchey D, Drake CJ, Wunsch AM, Little CD: Distribution of connective tissue proteins during development and neovascularization of the epicardium. Cardiovasc Res 1996;31:E104–E115.
236.
Zhang H, Hu W, Ramirez F: Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. J Cell Biol 1995;129:1165–1176.
237.
Glukhova MA, Frid MG, Shekhonin BV, Vasilevskaya TD, Grunwald J, Saginati M, Koteliansky VE: Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent. J Cell Biol 1989;109:357–366.
238.
Glukhova MA, Frid MG, Shekhonin BV, Balabanov YV, Koteliansky VE: Expression of fibronectin variants in vascular and visceral smooth muscle cells in development. Dev Biol 1990;141:193–202.
239.
Glukhova M, Koteliansky V, Fondacci C, Marotte F, Rappaport L: Laminin variants and integrin laminin receptors in developing and adult human smooth muscle. Dev Biol 1993;157:437–447.
240.
Rabinovitch M: Cell-extracellular matrix interactions in the ductus arteriosus and perinatal pulmonary circulation. Semin Perinatol 1996;20:531–541.
241.
Slomp J, Gittenberger-de Groot AC, Glukhova MA, van Munsteren JC, Kockx MM, Schwartz SM, Koteliansky VE: Differentiation, dedifferentiation, and apoptosis of smooth muscle cells during development of the human ductus arteriosus. Arterioscler Thromb Vasc Biol 1997;17:1003–1009.
242.
Schuger L, Skuitz APN, Zhang J, Sorokin L, He L: Laminin α1 chain synthesis in the mouse developing lung: Requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. J Cell Biol 1997;139:553–562.
243.
Yang Y, Palmer KC, Relan N, Diglio C, Schuger L: Role of laminin polymerization at the epithelial mesenchymal interface in bronchial myogenesis. Development 1998;125:2621–2629.
244.
DeBlois D, Lombardi DM, Su EJ, Clowes AW, Schwartz SM, Giachelli CM: Angiotensin II induction of osteopontin expression and DNA replication in rat arteries. Hypertension 1996;28:1055–1063.
245.
Brooks PC, Silletti S, von Schalscha TL, Friedlander M, Cheresh DA: Disruption of angiogenesis by PEX, an noncatalytic metalloproteinase fragment with integrin binding activity. Cell 1998;92:391–400.
246.
Schwartz SM, Heimark RL, Majesky MW: Developmental mechanisms underlying pathology of arteries. Physiol Rev 1990;70:1177–1209.
247.
Bobik A, Campbell JH: Vascular derived growth factors: Cell biology, pathophysiology, and pharmacology. Pharmacol Rev 1993;45:1–42.
248.
Newby AC, George SJ: Proposed roles for growth factors in mediating smooth muscle proliferation in vascular pathologies. Cardiovasc Res 1993;27:1173–1183.
249.
Nilsson J: Cytokines and smooth muscle cells in atherosclerosis. Cardiovasc Res 1993;27:1184–1190.
250.
Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Vivek J, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996;87:1161–1169.
251.
Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996;87:1171–1180.
252.
Folkman J, D’Amore PA: Blood vessel formation: What is its molecular basis? Cell 1996;87:1153–1155.
253.
Dumont DJ, Gradwohl G, Fong G-H, Puri MC, Gerstenstein M, Auerbach A, Breitman ML: Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek,, reveal a critical role in vasculogenesis of the embryo. Genes Dev 1994;8:1897–1909.
254.
Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR: Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 1996;87:1181–1190.
255.
Zerwes H-G, Risau W: Polarized secretion of a platelet-derived growth factor-like chemotactic factor by endothelial cells in vitro. J Cell Biol 1987;105:2037–2041.
256.
Shinbrot E, Peters KG, Williams LT: Expression of the platelet-derived growth factor β receptor during organogenesis and tissue differentiation in the mouse embryo. Dev Dyn 1994;199:169–175.
257.
Levéen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C: Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev 1994;8:1875–1887.
258.
Soriano P: Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Genes Dev 1994;8:1888–1896.
259.
Lindahl P, Johansson BR, Levéen P, Betsholtz C: Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997;277:242–245.
260.
Stephenson DA, Mercola M, Anderson E, Wang C, Stiles CD, Bowen-Pope DF, Chapman VM: Platelet-derived growth factor receptor α-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci USA 1991;88:6–10.
261.
Schatteman GC, Motley ST, Effmann EL, Bowen-Pope DF: Platelet derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis. Teratology 1995;51:351–366.
262.
Crosby JR, Seifert RA, Soriano P, Bowen-Pope DF: Chimaeric analysis reveals role of PDGF receptors in all muscle lineages. Nat Genet 1998;18:385–388.
263.
Shah NM, Groves AK, Anderson DJ: Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members. Cell 1996;85:331–343. Nat Genet 1998;18:385–388.
264.
Kanzaki T, Shiina R, Saito Y, Oohash H, Morisaki N: Role of latent TGF-β binding protein in vascular remodeling. Biochem Biophys Res Commun 1998;246:26–30.
265.
Fang J, Li X, Smiley E, Franke U, Mecham RP, Bonadio J: Mouse latent TGF-beta binding protein-2: Molecular cloning and developmental expression. Biochim Biophys Acta 1997;1354:219–230.
266.
Martin JS, Dickson MC, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ: Analysis of homozygous TGFβ1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis. Ann NY Acad Sci 1995;752:300–308.
267.
Böttinger EP, Letterio JJ, Roberts AB: Biology of TGF-β in knockout and transgenic mouse models. Kidney Int 1997:51:1355–1360.
268.
McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J, McCormick MK, Pericak-Vance MA, Heutink P, Oostra BA, Haitjema T, Westerman CJJ, Porteous ME, Guttmacher AE, Letarte M, Marchuk DA: Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 1994;8:345–351.
269.
Johnson DW, Berg JN, Baldwin MA, Gallione CJ, Marondel I, Yoon S-J, Stenzel TT, Speer M, Pericak-Vance MA, Diamond A, Guttmacher AE, Jackson CE, Attisano L, Kucherlapati R, Porteous MEM, Marchuk DA: Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 1996;13:189–195.
270.
Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, Bovin GP, Cardell EL, Doetschman T: TGFβ2 knockout mice have multiple developmental defects that are nonoverlapping with other TGFβ knockout phenotypes. Development 1997;124:2659–2670.
271.
Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J: Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 1995;11:415–421.
272.
Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN, Ding J, Ferguson MWJ, Doetschman T: Transforming growth factor-β3 is required for secondary palate fusion. Nat Genet 1995;11:409–414.
273.
Hautmann MB, Madsen CS, Owens GK: A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CarG elements. J Biol Chem 1997;272:10948–10956.
274.
Sucov HM: Molecular insights into cardiac development. Annu Rev Physiol 1998;60:287–308.
275.
Carmeliet P, Collen D: Molecular analysis of blood vessel formation and disease. Am J Physiol 1997;273:H2091–H2104.
276.
Coughlin SR: Sol Sherry lecture in thrombosis. How thrombin ‘talks’ to cells. Molecular mechanisms and roles in vivo. Arterioscler Thromb Vasc Biol 1998;18:514–518.
277.
Folkow B: ‘Structural autoregulation’ – The local adaptation of vascular beds to chronic changes in pressure. Ciba Foundation Symposium 100: Development of the Vascular System. Pitman, London 1983, pp 56–79.
278.
Guyton JR, Hartley CJ: Flow restriction of one carotid artery in juvenile rats inhibits growth of arterial diameter. Am J Physiol 1985;248:H540–H546.
279.
Langille BL, O’Donnell F: Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science 1986;231:405–407.
280.
Langille BL: Remodeling of developing and mature arteries: Endothelium, smooth muscle, and matrix. J Cardiovasc Pharmacol 1993;21(suppl 1):S11–S17.
281.
Mulvany MJ: Determinants of vasculature structure. J Cardiovasc Pharmacol 1992;19(S5):S1–S6.
282.
Hughes AFW: The blood pressure of the chick embryo during development. J Exp Biol 1942–1943;19:232–237.
283.
Girard H: Arterial pressure in the chick embryo. Am J Physiol 1973:224:454–460.
284.
Hu N, Clark EB: Hemodynamics of the stage 12 to stage 29 chick embryo. Circ Res 1989;65:1665–1670.
285.
Drushel RF, Pechak DG, Caplan AI: The anatomy, ultrastructural and fluid dynamics of the developing vasculature of the embryonic chick wing bud. Cell Differ 1985;16:13–28.
286.
Jargiello DM, Caplan AI: The establishment of vascular-derived microenvironments in the developing chick wing. Dev Biol 1983;97:364–374.
287.
Hogers B, DeRuiter MC, Gittenberger-de Groot AC, Poelmann RE: Unilateral vitelline vein ligation alters intracardiac blood flow patterns and morphogenesis in the chick embryo. Circ Res 1997;80:473–481.
288.
Skalak TC, Price RJ: The role of mechanical stresses in microvascular remodeling. Microcirculation 1996;3:143–165.
289.
Osol G: Mechanotransduction by vascular smooth muscle. J Vasc Res 1995;32:275–292.
290.
Wilson E, Sudhir K, Ives HE: Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. J Clin Invest 1995;96:2364–2372.
291.
Wilson E, Mai Q, Sudhir K, Weiss RH, Ives HE: Mechanical strain induces growth of vascular smooth muscle cells via autocrine production of PDGF. J Cell Biol 1993;123:741–747.
292.
Reusch P, Wagdy H, Reusch R, Wilson E, Ives HE: Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells. Circ Res 1996;79:1046–1053.
293.
Owens GK: Role of mechanical strain in regulation of differentiation of vascular smooth muscle cells. Circ Res 1996;79:1054–1055.
294.
Davies PF, Barbee KA, Volin MV, Roboteskyj A, Chen J, Joseph L, Griem ML, Wernick MN, Jacobs E, Polacek DC, DePaola N, Barakat AI: Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu Rev Physiol 1997;59:527–549.
295.
Resnick N, Gimbrone MA Jr: Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J 1995;9:874–882.
296.
Mondy JS, Linder V, Miyahro JK, Berk BC, Dean RH, Geary RL: Platelet-derived growth factor ligand and receptor expression in response to altered blood flow in vivo. Circ Res 1997;81:320–327.
297.
Ohno M, Cooke JP, Dzau VJ, Gibbons GH: Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. J Clin Invest 1995;95:1363.
298.
Topper JN, Cai J, Qiu Y, Anderson KR, Xu YY, Deeds JD, Feeley R, Gimenco CJ, Woolf EA, Tayber O, Mays GG, Samson BA, Schoen FJ, Gimbrone MA Jr, Falb D: Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci USA 1997;94:9314–9319.
299.
Ingber DE: Cellular tensegrity: Defining new rules of biological design that govern the cytoskeleton. J Cell Sci 1993;104:613–627.
300.
Fishman GI: Timing is everything in life: Conditional transgene expression in the cardiovascular system. Circ Res 1998;82:837–844.
1999
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