In order to study the action of serotonin (5-HT), noradrenaline (NA), hypertensin (HT), prostaglandins A1, B1 and E2 (PGA1, PGB1 and PGE2) and vasopressin (VP), internal carotid arteries were isolated in situ from both cerebral and general circulation and perfused continuously with oxygenated Ringers’ bicarbonate solution. The order of potencies of the vasoactive substances when administered intra-arterially was: 5-HT > HT > PGE2- > PGB1 > NA. The relative duration of the constrictor effects was: 5-HT < PGA1- < HT and PGE2 < PGB1 and NA < VP. The relaxation index of these substances on the vascular wall was: 5-HT < PGE2 < HT < PGB1- < NA < PGA1 < VP. Some of these substances, specifically PGB1 PGE2 and VP, frequently caused a residual constriction of the smooth muscle following their dilator effect. The role of these vasoactive substances in the development of vasospasm is discussed.

Keywords:
Internal carotid artery, Vasoconstriction, Arterial spasm (vasospasm), Serotonin, Prostaglandins, Noradrenaline, Vasopressin, Hypertensin
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© 1979 S. Karger AG, Basel
1979
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