.... Oxidative stress and subsequent inflammation are key factors in the development of common chronic metabolic diseases, such as obesity. We aimed to investigate the combined effects of genetic variations in CNDP1 and CNDP2 and dietary carbohydrate and carotene intake on obesity risk. Methods: A total of 1,059...

...-Cristobal; Jose Luis Santos; J. Alfredo Martínez Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention...

...Erik E.J.G. Aller; Edwin C.M. Mariman; Freek G. Bouwman; Marleen A. van Baak Background: Weight loss success is determined by genetic factors, which may differ according to treatment strategy. Methods: From a multidisciplinary obesity treatment program involving dietary advice, psychological...

...Myoungsook Lee; Jung-Im Kim; Seojin Choi; Yangsoo Jang; Sungbin Richard Sorn Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has...

... the variability in food preference and intake. Here, we aimed to determine whether genetic variation in the CD36 gene affects food intake and risk of obesity. Methods: A cross-sectional study was conducted with obese Brazilian children and adolescents ( n = 466; BMI-for-age z-score [zBMI] 3.29 ± 0.61) and normal...

...Carolina Ferreira Nicoletti; Marcela A. Souza Pinhel; Bruno Affonso Parenti de Oliveira; Julio Sergio Marchini; Wilson Salgado Junior; Wilson Araujo Silva Junior; Carla Barbosa Nonino Background/Aims: Genetic variants associated with obesity have cumulative effects on obesity risk and related...

...Daniel Antonio de Luis; Rocío Aller; Olatz Izaola; David Primo; Silvia Urdiales; Enrique Romero Background and Aims: The common polymorphism rs9939609 of the fat mass- and obesity-associated gene (FTO) has been linked to obesity. Our aim was to investigate its role in weight loss after...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hyperhomocysteinemia Overweight Obesity Vitamin B complex Cardiovascular...

... protocol, when the epididymal fat, gastrocnemius muscle and liver were excised. Results: Pparg2 mRNA expression was upregulated by obesity and downregulated by fish oil supplementation in the liver. In the gastrocnemius muscle, diet-induced obesity increased global DNA methylation. Fish oil prevented...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. MTNR1B FTO MC4R Obesity Body weight loss Gene-gene interplay Gene-diet interaction Obesity has...

... Silva Souza Background/Aim: We studied the molecular pathogenesis of obesity, involving complex interactions between environmental and genetic factors, with a focus on the leptin gene. It was our aim to characterize the LEP -2548G>A leptin polymorphism and lipid profile in obese and normal-weight...

...Azahara I. Rupérez; Josune Olza; Mercedes Gil-Campos; Rosaura Leis; María Dolores Mesa; Rafael Tojo; Ramón Cañete; Ángel Gil; Concepción M. Aguilera Background/Aims: Altered expression and activity of the antioxidant enzymes glutathione peroxidases (GPXs) have been observed in obesity in human...

..., and carbohydrate metabolisms. Alterations in these processes accelerate the progression of hepatic steatosis and insulin resistance during aging and obesity. Methods: Using an ex vivo chromatin immunoprecipitation coupled to microarray (ChIP-on-chip) technique combined with genome-wide gene expression analysis, we...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Obesity Weight regain Weight...

...Felix R. Day; Ruth J.F. Loos Obesity is an important factor contributing to the global burden of morbidity and mortality. By identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology. Early studies used candidate gene and genome-wide linkage approaches to search...

...Y.Y. Yako; B.L. Fanampe; M.S. Hassan; R.T. Erasmus; L. van der Merwe; S.J. van Rensburg; T.E. Matsha Background/Aims: Obesity has increased rapidly in South African children and adolescents. Genes involved in appetite regulation have been extensively studied worldwide, but their role in the obesity...

...F. Capel; M.H. Delmotte; M. Brun; M. Lonchampt; B. De Fanti; L. Xuereb; L. Baschet; G. Rolland; J.P. Galizzi; B. Lockhart; A. Ktorza; C. Dacquet Background: Aging and obesity induce complex transcriptomic changes in the liver, promoting the development of insulin resistance and type 2 diabetes...

...Pedro González-Muniesa; Cristiane de Oliveira; Fátima Pérez de Heredia; Mary P. Thompson; Paul Trayhurn Background/Aims: Hypoxia occurs in white adipose tissue in obesity, modulating the expression and release of specific inflammation-related adipokines. ANGPTL4 (angiopoietin-like protein 4/fasting...

...Tiina Lappalainen; Marjukka Kolehmainen; Ursula Schwab; Leena Pulkkinen; Vanessa D.F. de Mello; Maija Vaittinen; David E. Laaksonen; Kaisa Poutanen; Matti Uusitupa; Helena Gylling Background/Aims: The common polymorphism rs9939609 of the fat mass and obesity-associated gene ( FTO) is strongly...

...A. Lomba; F.I. Milagro; D.F. García-Díaz; J. Campión; F. Marzo; J.A. Martínez Background/Aim: Changes in dietary macronutrient content are involved in altered energy metabolism and obesity development. However, there are controversial views about the obesogenic effects of high-sucrose (HS) diets...