...Philip Thomas; Michael Fenech Background/Aims: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and is the commonest form of dementia. One aim of this study was to determine whether AD individuals have altered plasma folate, vitamin B 12 and homocysteine (Hcy) levels compared...

...Reyad Al-Ghnaniem Abbadi; Peter Emery; Maria Pufulete Background/Aims: Low folate intake may increase risk of colorectal cancer by altering gene-specific methylation in the colon. We determined whether supplementation with physiological doses of folate could alter methylation in the oestrogen...

...Patrick J. Stover Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability...

..., female, identical and non-identical twins aged 50–80 years. Each twin was administered folic acid (0.8 mg/day) for 6 weeks. Total plasma folate, cobalamin and tHcy were measured at both baseline and after dosing. We calculated the heritability and tested for associations between the MTHFR C677T...

...Xiaowei Ng; Lyndell Boyd; Lisa Dufficy; Nenad Naumovski; Barbara Blades; Cheryl Travers; Peter Lewis; Jonathon Sturm; Zoë Yates; Maureen Townley-Jones; Paul Roach; Martin Veysey; Mark Lucock Background/Aims: 118 elderly participants (65–90 years) were assessed for any relationship between folate...

...Susan E. Steck; Temitope Keku; Lesley M. Butler; Joseph Galanko; Beri Massa; Robert C. Millikan; Robert S. Sandler Background/Aims: We examined associations among folate and alcohol intake, single nucleotide polymorphisms (SNPs) in genes involved in one-carbon metabolism, and colon cancer risk...

.... Proteomics Nutrition Nutrigenomics Nutrient requirement Biotin Yeast Saccharomyces cerevisiae Folate Mini Review J Nutrigenet Nutrigenomics 2008;1:55 58 DOI: 10.1159/000109875 Received: February 15, 2007 Accepted: March 7, 2007 Published online: October 16, 2007 Role of Proteomics in the Study...