Background/Aims: To determine whether variation in the TAS1R2 gene affects sucrose taste perception and sugar intake. Methods: Participants were men (n = 238) and women (n = 458) aged 20-29 years. A subset (n = 95) with body mass index (BMI) data available completed a sensory analysis study. A food frequency questionnaire assessed dietary intake, and eight polymorphisms were genotyped (rs12033832, rs12137730, rs35874116, rs3935570, rs4920564, rs4920566, rs7513755 and rs9701796). Sucrose taste thresholds were determined by staircase procedure (solutions: 9 × 10-6 to 0.5 mol/l). Suprathreshold sensitivity to 0.01-1.0 mol/l sucrose solutions was assessed using general Labeled Magnitude Scales. Results: A significant genotype-BMI interaction was observed for rs12033832 (G>A) for suprathreshold sensitivity (p = 0.01) and sugar intake (p = 0.003). Among participants with a BMI ≥25, G allele carriers had lower sensitivity ratings (mean incremental area under the taste sensitivity curve ± SE; GG/GA 54.4 ± 4.1 vs. AA 178.5 ± 66.6; p = 0.006), higher thresholds (GG/GA 9.3 ± 1.1 vs. AA 4.4 ± 4.3 mmol/l; p = 0.004) and consumed more sugars (GG/GA 130 ± 4 vs. AA 94 ± 13 g/day; p = 0.009). G allele carriers with a BMI <25 had lower thresholds (GG/GA 8.6 ± 0.5 vs. AA 16.7 ± 5.7 mmol/l; p = 0.02) and consumed less sugars (GG/GA 122 ± 2 vs. AA 145 ± 8 g/day; p = 0.004). Conclusion: The rs12033832 single nucleotide polymorphism in TAS1R2 is associated with sucrose taste and sugar intake, but the effect differs depending on BMI.

1.
El-Sohemy A, Stewart L, Khataan N, Fontaine-Bisson B, Kwong P, Ozsungur S, Cornelis MC: Nutrigenomics of taste - impact on food preferences and food production. Forum Nutr 2007;60:176-182.
2.
Garcia-Bailo B, Toguri C, Eny KM, El-Sohemy A: Genetic variation in taste and its influence on food selection. OMICS 2009;13:69-80.
3.
Blakeslee AF, Salmon TN: Genetics of sensory thresholds: individual taste reactions for different substances. Proc Natl Acad Sci USA 1935;21:84-90.
4.
Henkin RI, Shallenberger RS: Aglycogeusia: the inability to recognize sweetness and its possible molecular basis. Nature 1970;227:965-966.
5.
Keskitalo K, Tuorila H, Spector TD, Cherkas LF, Knaapila A, Silventoinen K, Perola M: Same genetic components underlie different measures of sweet taste preference. Am J Clin Nutr 2007;86:1663-1669.
6.
Eny KM, Wolever TM, Corey PN, El-Sohemy A: Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. Am J Clin Nutr 2010;92:1501-1510.
7.
Fushan AA, Simons CT, Slack JP, Drayna D: Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Chem Senses 2010;35:579-592.
8.
Fushan AA, Simons CT, Slack JP, Manichaikul A, Drayna D: Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr Biol 2009;19:1288-1293.
9.
Mennella JA, Finkbeiner S, Reed DR: The proof is in the pudding: children prefer lower fat but higher sugar than do mothers. Int J Obes (Lond) 2012;36:1285-1291.
10.
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS: The receptors and cells for mammalian taste. Nature 2006;444:288-294.
11.
Liao J, Schultz PG: Three sweet receptor genes are clustered in human chromosome 1. Mamm Genome 2003;14:291-301.
12.
Chaudhari N, Roper SD: The cell biology of taste. J Cell Biol 2010;190:285-296.
13.
McCaughey SA: The taste of sugars. Neurosci Biobehav Rev 2008;32:1024-1043.
14.
Ettinger L, Duizer L, Caldwell T: Body fat, sweetness sensitivity, and preference: determining the relationship. Can J Diet Pract Res 2012;73:45-48.
15.
Galindo-Cuspinera V, Waeber T, Antille N, Hartmann C, Stead N, Martin N: Reliability of threshold and suprathreshold methods for taste phenotyping: characterization with prop and sodium chloride. Chemosens Percept 2009;2:214-228.
16.
Eny KM, Wolever TM, Fontaine-Bisson B, El-Sohemy A: Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations. Physiol Genomics 2008;33:355-360.
17.
Eny KM, Corey PN, El-Sohemy A: Dopamine D2 receptor genotype (C957T) and habitual consumption of sugars in a free-living population of men and women. J Nutrigenet Nutrigenomics 2009;2:235-242.
18.
Dias AG, Rousseau D, Duizer L, Cockburn M, Chiu W, Nielsen D, El-Sohemy A: Genetic variation in putative salt taste receptors and salt taste perception in humans. Chem Senses 2013;38:137-145.
19.
Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y: Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Diabetes 2008;57:2661-2665.
20.
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295.
21.
Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y: Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci USA 2000;97:11044-11049.
22.
Zheng H, Lenard NR, Shin AC, Berthoud HR: Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond) 2009;33(suppl 2):S8-S13.
23.
Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz M, Rayner CK, Blackshaw LA: Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 2009;58:337-346.
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