Background: The emergence of nutritional genomics and the availability of nutrigenetic tests, which use genetic information to identify food products suited/not suited to the individual nutrigenetic profile, allow defining personalized dietary advice. Aim: To compare personalized dietary advice provided to 24 Italian children by a nutrigenetic test based on the recommendations from 2 different, widely employed nutrient profiling (NP) schemes, the USA Health Claims (USAHC) and the Guidelines for Responsible Food Marketing to Children, published by the US Center for Science in the Public Interest (CSPI); the genetic test-NP agreement regarding 50 commonly eaten foods has been calculated. Methods: Twelve normal-weight and 12 overweight children were recruited in the Trieste district (North-East Italy), and nutrigenetic testing was offered using the G-Diet® Nutrigenomic Kit. Variants of 20 genes were tested and personalized dietary advice was formulated for each subject. The agreement between the NP schemes and among the nutrigenomic indications and both profiles was computed using Cohen’s ĸ. Results: Agreement between the USAHC and CSPI schemes was very poor overall (Cohen’s ĸ = 0.66). The agreement among the nutrigenomic indications and profiles ranged overall from 0.43 to 0.74 for each nutrigenomic profile with the USAHC, and from 0.29 to 0.80 with the CSPI. Conclusion: Disagreement on food classification among different NP schemes and inconsistencies deriving from nutrigenetic tests advocate more research into this area.

1.
Komduur RH, Korthals M, te Molder H: The good life: living for health and a life without risks? On a prominent script of nutrigenomics. Br J Nutr 2009;101:307–316.
2.
Han JC, Lawlor DA, Kimm SY: Childhood obesity. Lancet 2010;375:1737–1748.
3.
Visioli F, Poli A, Peracino A, Luzi L, Cannella C, Paoletti R: Assessment of nutritional profiles: a novel system based on a comprehensive approach. Br J Nutr 2007;98:1101–1107.
4.
Rayner M, Scarborough P, Williams C: The origin of Guideline Daily Amount and the Food Standard Agency’s guidance on what counts as ‘a lot’ and ‘a little’. Public Health Nutr 2004;7:549–556.
5.
Food Standards Agency: Scientific workshop to assess the Food Standards Agency’s proposed approach to nutrient profiling. 2005. http://www.food.gov.uk/multimedia/pdfs/nutprofworkshop250205.pdf.
6.
Drewnowski A, Maillot M, Darmon N: Should nutrient profiles be based on 100 g, 100 kcal or serving size? Eur J Clin Nutr 2009;63:898–904.
7.
Loktionov A: Common gene polymorphisms and nutrition: emerging links with pathogenesis of multifactorial chronic diseases. J Nutr Biochem 2003;14:426–451.
8.
Müller M, Kersten S: Nutrigenomics: goals and strategies. Nat Rev Genet 2003;4:315–322.
9.
Sanderson SC, Wardle J, Humphries SE: Public health genomics and genetic test evaluation: the challenge of conducting behavioural research on the utility of lifestyle-genetic tests. J Nutrigenet Nutrigenomics 2008;1:224–231.
10.
Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, Grimaldi KA: Improved weight management using genetic information to personalize a calorie controlled diet. Nutr J 2007;6:29.
11.
Marteau TM, Lerman C: Genetic risk and behavioural change. BMJ 2001;322:1056–1059.
12.
Roses AD: Pharmacogenetics and the practice of medicine. Nature 2000;405:857–865.
13.
Mizuta E, Kokubo Y, Yamanaka I, Miyamoto Y, Okayama A, Yoshimasa Y, Tomoike H, Morisaki H, Morisaki T: Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens Res 2008;31:1069–1077.
14.
El-Sohemy A, Stewart L, Khataan N, Fontaine-Bisson B, Kwong P, Ozsungur S, Cornelis MC: Nutrigenomics of taste: impact on food preferences and food production. Forum Nutr 2007;60:176–182.
15.
Ingram CJ, Mulcare CA, Itan Y, Thomas MG, Swallow DM: Lactose digestion and the evolutionary genetics of lactase persistence. Hum Genet 2009;124:579–591.
16.
Messika AH, Kaluski DN, Lev E, Iakobishvili Z, Shohat M, Hasdai D, Mager A: Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes. Eur J Cardiovasc Prev Rehabil 2010, E-pub ahead of print.
17.
Vimaleswaran KS, Radha V, Ghosh S, Majumder PP, Deepa R, Babu HN, Rao MR, Mohan V: Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene polymorphisms and their relationship to type 2 diabetes in Asian Indians. Diabet Med 2005;22:1516–1521.
18.
Ereqat S, Nasereddin A, Azmi K, Abdeen Z, Amin R: Impact of the Pro12Ala polymorphism of the PPAR- γ2 gene on metabolic and clinical characteristics in the Palestinian type 2 diabetic patients. PPAR Res 2009;2009:874126.
19.
Ereqat S, Nasereddin A, Cauchi S, Azmi K, Abdeen Z, Amin R: Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population. Acta Diabetol 2009, E-pub ahead of print.
20.
Stefanyk LE, Dyck DJ: The interaction between adipokines, diet and exercise on muscle insulin sensitivity. Curr Opin Clin Nutr Metab Care 2010;13:255–259.
21.
Kursawe R, Narayan D, Cali AM, Shaw M, Pierpont B, Shulman GI, Caprio S: Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis. Obesity (Silver Spring) 2010;18:1911–1917.
22.
Majumdar ID, Weber HC: Gastrointestinal regulatory peptides and their effects on fat tissue. Curr Opin Endocrinol Diabetes Obes 2010;17:51–56.
23.
Kjaergaard AD, Ellervik C, Tybjaerg-Hansen A, Axelsson CK, Grønholdt ML, Grande P, Jensen GB, Nordestgaard BG: Estrogen receptor-α polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis. Circulation 2007;115:861–871.
24.
Yadav VK, Ducy P: Lrp5 and bone formation: a serotonin-dependent pathway. Ann NY Acad Sci 2010;1192:103–109.
25.
Arias-Vásquez A, Sayed-Tabatabaei FA, Schut AF, Hofman A, Bertolli-Avella AM, Vergeer JM, Aulchenko YS, Witteman JC, van Duijn CM: Angiotensin-converting enzyme gene, smoking and mortality in a population-based study. Eur J Clin Invest 2005;35:444–449.
26.
Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT: A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet 2009;18:2922–2927.
27.
Williams C, Rayner M, Myatt M, Boaz A: Use your label: making sense of nutrition information. Food sense leaflet. London, Ministry of Agriculture Fisheries and Food, 1996.
28.
Center for Science in the Public Interest: Guidelines for responsible food marketing to children. Washington, Center for Science in the Public Interest, 2005.
29.
Food and Nutrition Board Institute of Medicine: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, National Academies Press, 2002.
30.
Cohen J: A coefficient of agreement for nominal scales. Educ Psychol Meas 1960;20:37–46.
31.
Garsetti M, de Vries J, Smith M, Amosse A, Rolf-Pedersen N: Nutrient profiling schemes: overview and comparative analysis. Eur J Nutr 2007;46(suppl 2):15–28.
32.
Zeisel SH: Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am J Clin Nutr 2007;86:542–548.
33.
Ames BN: Cancer prevention and diet: help from single nucleotide polymorphisms. Proc Natl Acad Sci USA 1999;96:12216–12218.
34.
Papoutsakis C, Manios Y, Magkos F, Papaconstantinou E, Schulpis KH, Zampelas A, Matalas AL, Yiannakouris N: Effect of the methylenetetrahydrofolate reductase (MTHFR 677C→T) polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods. Nutrition 2010;26:969–974.
35.
Selhub J, Jacques PF, Bostom AG, D’Agostino RB, Wilson PW, Belanger AJ, O’Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH: Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995;332:286–291.
36.
Meshkin B, Blum K: Folate nutrigenetics: a convergence of dietary folate metabolism, folic acid supplementation, and folate antagonist pharmacogenetics. Drug Metab Lett 2007;1:55–60.
37.
Haga SB, Khoury MJ, Burke W: Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat Genet 2003;34:347–350.
38.
Janssens AC, Gwinn M, Bradley LA, Oostra BA, van Duijn CM, Khoury MJ: A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet 2008;82:593–599.
39.
Ashfield-Watt PA, Pullin CH, Whiting JM, Clark ZE, Moat SJ, Newcombe RG, Burr ML, Lewis MJ, Powers HJ, McDowell IF: Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial. Am J Clin Nutr 2002;76:180–186.
40.
Bazzano LA, Reynolds K, Holder KN, He J: Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA 2006;296:2720–2726.
41.
de Vrieze J, Bouwman L, Komduur R, Pin R, Ronteltap A, Vandeberg R, van Dam F, Penders B: Nutrition tailored to the individual? Not just yet – realigning nutrigenomic science with contemporary society. J Nutrigenet Nutrigenomics 2009;2:184–188.
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