...R.D. Hunt; L.V. Meléndez; N.W. King; F.G. Garcia Herpesvirus saimiri resulted in the development of malignant lymphoma in 2 of 6 spider monkeys (Ateles geoffroyi) inoculated via the intramuscular route. One monkey died 129 days after inoculation and the other was sacrificed at 179 days. The disease...

...R.H. Neubauer; W.C. Wallen; H. Rabin; G.R. Pearson; D.V. Ablashi Examination of owl monkeys with Herpesvirus saimiri (HVS) infections failed to reveal site of active viral replication. Virus was readily rescued by cocultivation from many tissues; however, infectious virus or viral antigens were...

...William C. Wallen; Russel H. Neubauer Lymphoid cells from Herpesvirus saimiri infected owl monkeys were found to react mitogenically to large doses of phytohemagglutinin, to be highly cytotoxic for certain fibroblastic cell lines in a nonspecific manner, and to produce interferon. No released...

...R.H. Adamson; D.V. Ablashi; J.L. Cicmanec; D.W. Dalgard Multiplication of Herpesvirus saimiri in vitro is inhibited by cytosine arabinoside and adenine arabinoside. Lymphoma-leukemia induced by HVS in owl monkeys is responsive to several anticancer drugs. Problems associated with treatment of HVS...

... Morphological description is given of the propagation of Herpesvirus saimiri in productively infected owl monkey kidney cells. The morphology and life cycle of the virus and cellular alterations due to viral infection are described. Although belonging to the herpes group, the maturation...

... with the response of lymphocytes to different mitogens was investigated in owl monkeys infected with Herpesvirus saimiri (HVS). There was a positive correlation between the production of antibodies to EA and the quantitative recovery of virus from peripheral blood lymphocytes. The loss of responsiveness...

...John J. Cicmanec; Walter F. Loeb; Marion G. Valerio Thirteen of 18 owl monkeys inoculated with intact Herpesvirus saimiri (HVS) developed lymphomas with a protracted clinical course. Lymphadenopathy and splenomegaly were apparent 40-177 days postinoculation in affected monkeys which survived 56-203...

...H. Barahona; F.G. Garcia; L.V. Melendez; R.D. Hunt A method for the isolation of lymphocyte-associated viruses in cocultures kept under stressing cultural conditions for a long term was developed. This procedure was used in an epidemiological field study of Herpesvirus saimiri in South American...