Thirteen of 18 owl monkeys inoculated with intact Herpesvirus saimiri (HVS) developed lymphomas with a protracted clinical course. Lymphadenopathy and splenomegaly were apparent 40-177 days postinoculation in affected monkeys which survived 56-203 days. Lymphocytic leukemia was present in 10 of the 13 affected animals, and actively motile lymphocytes were,present in peripheral blood of all affected monkeys. Lymphomas were also induced in 2 of 2 owl monkeys inoculated with repeated injections of heat-inactivated HVS,and in 2 of 3 monkeys inoculated with HVS-induced lymphoma cells.

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