Lymphoid cells from Herpesvirus saimiri infected owl monkeys were found to react mitogenically to large doses of phytohemagglutinin, to be highly cytotoxic for certain fibroblastic cell lines in a nonspecific manner, and to produce interferon. No released immunoglobulin or lymphotoxin was detected in culture fluids from these cells. Nonspecific receptors for sheep erythrocytes were detected on about 90% of cultured HVS cells from owl monkeys and from one line of marmoset monkey origin. These cells lacked receptor for modified complement as well as readily detectable immunoglobulin.

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