Successful isohemagglutinin formation was obtained by inter- and intrasubspecies immunizations of the marmoset, S. fuscicollis(ssp.) The responses were characterized primarily by formation of incomplete agglutinins. A few animals also produced a cold agglutinin, a cold autoagglutinin, and a complete antibody reactive at room temperature. Sucrose density gradient analyses and treatment of the sera with 2-mercaptoethanol (2-ME) revealed the latter three agglutinins to be 19S proteins, while the incomplete antibody was found to be a 7S agglutinin. With one of the incomplete agglutinins a distinction could be made between 2 of 4 subspecies tested; intrasubspecies differences were not apparent. Another reagent was found to be specific for 1 of 4 subspecies tested, and demonstrated differences within this subspecies. Inter- and intrasubspecies breedings of these animals indicate that the reagents are detecting genotypic as well as phenotypic markers.

Keywords:
Marmosets, Blood groups, Chimerism, Immunogenetics
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1972
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