... demonstrated the roles of these degradative enzymes in the endothelial cells using a Kgp-specific inhibitor and P. gingivalis gingipain-null mutants, in which the lack of the proteinases resulted in the absence of PAI-1 degradation. The degradation of PAI-1 by P. gingivalis induced a delayed wound healing...

... represses Jak/STAT and Wingless signaling. Further experiments have confirmed that IDGF3 has multiple roles in innate immunity. It serves as an essential component required for the formation of hemolymph clots that seal wounds, and Idgf3 mutants display an extended developmental delay during wound healing...

... facilitates an M1/M2 switch, resulting in more efficient wound healing in animal models generated with either transgenic or bone marrow transplant procedures. The M2-suppressive effect is elicited by a new function of RIP140 that, in macrophages exposed to M2 cues, is exported to cytosol, forming complexes...

... and M2 macrophages Innate immunity Wound healing Arginase Nitric oxide Animal life seems to have begun as a ‘macrophage'. Amoebas are free-living ‘macrophages' able to phagocytize foreign objects, kill if necessary and repair cellular damage [ 1,2 ]. Macrophages in higher animals retained...

... of the laminin α3, α4 and α5 chain in vitro and in vivo. We show enhanced expression and processing of the LG4-5 module of laminin α3 in keratinocytes after infection and in chronic wounds in which the level of expression and further processing of the LG4-5 module correlated with the speed of wound healing...

... of homeostasis as well as regaining homeostasis after injury. Here we propose to classify macrophage phenotypes according to prototypical tissue environments, e.g. as they occur during homeostasis as well as during the different phases of (dermal) wound healing. In tissue necrosis and/or infection, damage...

... form phenoloxidase (PO), a key enzyme that leads to the formation of melanin at wound sites and around intruding microorganisms in the hemolymph. Clotting is critical in limiting hemolymph loss and initiating wound healing following injury; it quickly acts to form a solid barrier against infection...

... 6, 2010 Key Words Coagulation Comparative immunology Immune response Insects Invertebrates Wound healing Abstract In most animals there is a need to quickly prevent the loss of blood or equivalent fluids through inflicted injuries. In invertebrates with an open circulatory system...

... Hemostasis Innate immunity Insects Pattern recognition Sepsis Wound healing Journal of Innate Immunity Research Article J Innate Immun 2009;1:301 308 DOI: 10.1159/000168009 Received: June 26, 2008 Accepted after revision: August 14, 2008 Published online: October 30, 2008 Activation of Insect...