.... Cold atmospheric plasma Oxidation Virulence factor Streptococcus pyogenes M1 protein Cold atmospheric plasma (CAP) is emerging as a promising tool for medical applications as an antiseptic for infections and wound management. Though its therapeutic application has been investigated...

... arms race with the host where complement has become a major target to promote immune evasion. Streptococcus pyogenes is a major human pathogen that causes significant morbidity and mortality globally. S. pyogenes is also a member of an elite group of bacterial pathogens possessing a sophisticated...

... found that Streptococcus pyogenes - an important human pathogen - protects itself from histone-killing by the acquisition of plasminogen. Plasminogen, bound to the streptococcal surface, efficiently prevents histone-mediated killing. Moreover, the streptokinase/plasminogen complex degrades all classes...

...Julia Uhlmann; Manfred Rohde; Nikolai Siemens; Bernd Kreikemeyer; Peter Bergman; Linda Johansson; Anna Norrby-Teglund Reports have shown that the antimicrobial peptide LL-37 is abundantly expressed but has limited bactericidal effect in Streptococcus pyogenes infections. At sub-inhibitory...

.... Avirulent GAS infection was associated with lower levels of proinflammatory cytokines and tissue PMN apoptosis. We propose that the differences in PMN cell death mechanisms influence the inflammatory responses to infection by GAS. martina@uow.edu.au Group A Streptococcus ( Streptococcus pyogenes...

...Anja Ochel; Manfred Rohde; Gursharan S. Chhatwal; Susanne R. Talay Serotype M1 Streptococcus pyogenes is a major human pathogen associated with severe invasive diseases causing high morbidity and mortality. In a substantial number of cases, invasive disease develops in previously healthy...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Complement Innate immunity M protein Phagocytosis Plasmin(ogen) Streptococcus pyogenes The complement system is a critical component...

... in the amplification of inflammatory responses triggered during infection. In the present study, we have investigated the clinical significance of TREM-1 in Streptococcus pyogenes -induced severe sepsis in both experimentally infected mice as well as in patients with streptococcal toxic shock. We found that S...

...Ulrich von Pawel-Rammingen Survival of the important bacterial pathogen Streptococcus pyogenes relies on its ability to circumvent the antimicrobial actions of innate and specific immune responses and to modulate the inflammatory responses induced during the course of an infection. Inflammatory...

...Erika Hertzén; Linda Johansson; Robert Wallin; Heike Schmidt; Mirko Kroll; Anders P. Rehn; Malak Kotb; Matthias Mörgelin; Anna Norrby-Teglund Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock...

.... Group A Streptococcus Streptococcus pyogenes Virulence factor Innate immunity M protein Neutrophil Mast cell Extracellular traps Antimicrobial peptide Cathelicidin Journal of Innate Immunity Research Article J Innate Immun 2009;1:202 214 DOI: 10.1159/000203645 Received: November 27, 2008...