...Prabhakar Arumugam; Tammy Kielian Background: Staphylococcus aureus ( S. aureus ) is a common cause of hospital- and community-acquired infections that can result in various clinical manifestations ranging from mild to severe disease. The bacterium utilizes different combinations of virulence...

...Marieke M. Kuijk; Yongzheng Wu; Vincent P. van Hensbergen; Gizem Shanlitourk; Christine Payré; Gérard Lambeau; Sandra Man-Bovenkerk; Jennifer Herrmann; Rolf Müller; Jos A.G. van Strijp; Yvonne Pannekoek; Lhousseine Touqui; Nina M. van Sorge Methicillin-resistant Staphylococcus aureus (MRSA) has...

...Eva-Lena Stange; Franziska Rademacher; Katharina Antonia Drerup; Nina Heinemann; Lena Möbus; Regine Gläser; Jürgen Harder Staphylococcus aureus is an important pathogen causing various infections, including – as most frequently isolated bacterium – cutaneous infections. Keratinocytes as the first...

...Antje D. Paulikat; Lea A. Tölken; Lana H. Jachmann; Gerhard Burchhardt; Sven Hammerschmidt; Nikolai Siemens Influenza A Virus (IAV), Staphylococcus aureus (staphylococci), and Streptococcus pneumoniae (pneumococci) are leading viral and bacterial causes of pneumonia. Dendritic cells (DCs...

... the generation and maintenance of MDSCs in chronic Staphylococcus aureus infection. We found that MDSCs originate not only in the bone marrow but also at extramedullary sites in S. aureus -infected mice. scRNA-seq showed that infection-driven MDSCs encompass a spectrum of myeloid precursors in different stages...

... responses. We recently demonstrated that human Langerhans cells interact with the Gram-positive pathogen Staphylococcus aureus through the Langerhans cell-specific receptor langerin (CD207). It was previously hypothesized that two linked single nucleotide polymorphisms (SNPs; N288D and K313I...

... whether Staphylococcus aureus lipoproteins are essential for inducing PGE 2 secretion by immune cells and whether pattern recognition receptors mediate this process. PGE 2 levels secreted by mouse peritoneal macrophages infected with the S. aureus isogenic mutant, lgt ::ermB (Δ lgt ; deficient...

... a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia...

... responses and subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus . Many studies have demonstrated the importance of TLR2 in murine S. aureus infection...

...Constanza Giai; Cintia D. Gonzalez; Florencia Sabbione; Ailin Garofalo; Diego Ojeda; Daniel O. Sordelli; Analía S. Trevani; Marisa I. Gómez Interleukin 1 (IL-1) β is a critical cytokine that orchestrates host defenses against Staphylococcus aureus and is crucial for the eradication of bacteria...

...Russell E.N. Becker; Bryan J. Berube; Georgia R. Sampedro; Andrea C. DeDent; Juliane Bubeck Wardenburg Immunomodulatory cytotoxins are prominent virulence factors produced by Staphylococcus aureus , a leading cause of bacterial sepsis, skin infection, and pneumonia. S. aureus α-toxin is a pore...

...Thea Lu; Adeline R. Porter; Adam D. Kennedy; Scott D. Kobayashi; Frank R. DeLeo Neutrophils are essential for host defense against Staphylococcus aureus infections. Although significant progress has been made, our understanding of neutrophil interactions with S. aureus remains incomplete...

... that contain a Toll/interleukin-1 receptor (TIR) domain. The pathogen Staphylococcus aureus produces several innate immune-evasion molecules that interfere with the host's innate immune response. A database search analysis suggested the presence of a gene encoding a homologue of the human TIR domain in S...

...Yun Yun Pang; Jamie Schwartz; Sarah Bloomberg; Jeffrey M. Boyd; Alexander R. Horswill; William M. Nauseef To establish infection successfully, Staphylococcus aureus must evade clearance by polymorphonuclear neutrophils (PMN). We studied the expression and regulation of the methionine sulfoxide...

...Monika Jusko; Jan Potempa; Tomasz Kantyka; Ewa Bielecka; Halie K. Miller; Magdalena Kalinska; Grzegorz Dubin; Peter Garred; Lindsey N. Shaw; Anna M. Blom Staphylococcus aureus is an opportunistic pathogen that presents severe health care concerns due to the prevalence of multiple antibiotic...

...Evelien T.M. Berends; Alexander R. Horswill; Nina M. Haste; Marc Monestier; Victor Nizet; Maren von Köckritz-Blickwede Neutrophils are key effectors of the host innate immune response against bacterial infection. Staphylococcus aureus is a preeminent human pathogen, with an ability to produce...

..., the specificity of the antimicrobial effects has not been adequately described. We set out to determine the specific antimicrobial pattern of polypeptides in neutrophils (polymorphonuclear leukocytes, PMNs) against 4 potential human pathogens: Moraxella catarrhalis, Staphylococcus aureus, Haemophilus influenzae...

...Maren von Köckritz-Blickwede; Stephanie Konrad; Simon Foster; J. Engelbert Gessner; Eva Medina The complement system is a key component of the innate immune response. Here, we have examined the role of complement anaphylatoxin C5a in an experimental model of Staphylococcus aureus bacteremia. Our...

... and eliminating phagocytes by Staphylococcus aureus . Staphopain B (SspB) selectively cleaved CD11b on phagocytes, which rapidly acquired features of cell death. SspB-treated phagocytes expressed phosphatidylserine as well as annexin I and became permeable to propidium iodide, thus demonstrating distinctive...