...) and the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in sepsis induced by E . coli infection remain unclear. Methods: In vivo, we investigated differences in mortality, production of inflammatory mediators, organ damage, neutrophil count, and bacterial load during E . coli...

... that were further aggravated in chorioamnionitis cases. They showed a markedly reduced TLR4 expression and hampered LPS-stimulated cytokine responses 14 days after birth. Notably, at later timepoints, TLR4 expression and LPS responses no longer correlated. Sepsis during the first weeks of life strongly...

... an important role in hemostasis and immune responses by transfer of bioactive cargo from the parent cells. Platelet activation and release of EVs increase in several pathological inflammatory diseases, such as sepsis. We have previously reported that the M1 protein released from the bacterial pathogen...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 Olfactomedin-4 Neutrophil subpopulations Proteome Sepsis The neutrophil granulocyte, the most abundant...

.... 2022 Sepsis Endotoxin tolerance Cytokines Ex vivo Inflammation Monocytes Inflammatory syndromes such as sepsis, mainly due to bacterial infections but also caused by viral infections such as COVID-19, pose a major health care burden. Even prior to the COVID-19 pandemic, sepsis...

..., pulmonary edema, and inflammatory cell infiltration into lung tissues were then assessed, and TNF-α and IL-6 levels in serum and lung tissues were measured. The results indicated that RIPC could attenuate ALI in sepsis. miR-142-5p expression was increased in serum, lung tissues, and serum-derived EVs of ALI...

...Zhen-Mi Liu; Xi Wang; Chen-Xi Li; Xue-Yan Liu; Xiao-Jing Guo; Yang Li; You-Lian Chen; Hong-Xing Ye; Huai-Sheng Chen As a serious and elusive syndrome caused by infection, sepsis causes a high rate of mortality around the world. Our investigation aims at exploring the role and possible mechanism...

...Jane Fisher; Fredrik Kahn; Elena Wiebe; Pontus Gustafsson; Thomas Kander; Lisa Mellhammar; Peter Bentzer; Adam Linder Heparin-binding protein (HBP) is a promising biomarker for the development and severity of sepsis. To guide its use, it is important to understand the factors that could lead...

... infection Complement C4d Terminal complement complex Sepsis Necrotizing soft-tissue infection (NSTI) is a rapidly progressing bacterial infection, causing widespread necrosis in any layer of the soft-tissue compartment [1]. Patients with NSTI are severely ill, and the majority require intensive...

...Isatou Bah; Tuqa Alkhateeb; Dima Youssef; Zhi Q. Yao; Charles E. McCall; Mohamed El Gazzar Sepsis-induced myeloid-derived suppressor cells (MDSCs) increase mortality risk. We previously identified that long non-coding RNA Hotairm1 supports myeloid precursor shifts to Gr1 + CD11b + MDSCs during...

...Ramy S. Gabarin; Manshu Li; Paige A. Zimmel; John C. Marshall; Yimin Li; Haibo Zhang Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to infection. During gram-negative bacterial infection and other acute illness such as absorption from the gut infection...

...), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb −/− ) mice with sepsis. As a proof of concept study, we activated macrophages with BG combined with LPS (BG + LPS). We found that BG + LPS predominantly upregulated Syk expression and proinflammatory...

...Theodora A.M. Claushuis; Alex F. de Vos; Joris J.T.H. Roelofs; Onno J. de Boer; Cornelis van ’t Veer; Tom van der Poll Platelet-dense (δ) granules are important for platelet function. Platelets contribute to host defense and vascular integrity during pneumonia and sepsis, and δ granule products...

.... Likewise, the management of organism toxicity in septic shock is complicated and comprises a multiplicity of suitable targets. In this review, the classic immune responses to pathogens are discussed as well as other factors that are relevant in the pathogenicity of septic shock, including sepsis-induced...

.... These data are presented as adjusted odds ratios (aOR) with 95% confidence intervals (95% CI) and the associated p values. For this analysis, we studied subjects who had been enrolled into our single-center study of genetic factors associated with posttraumatic sepsis. This cohort has been presented...

... inflammation, namely, a postoperative cardiac surgery cohort. Genetic variants are potential risk factors for susceptibility to sepsis and death [ 17,18 ]. Genetic variants in key genes of the immune response, including IL10 , have been studied in patients experiencing septic shock [ 18,19...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Immune responses Macrophages Sepsis Macrophages were seeded in 24-well plates at a concentration of 10 6 cells/mL and infected with S. pyogenes WT or mutant strains...

...Kelly Roveran Genga; James A. Russell Sepsis, the most common cause of admission to an intensive care unit (ICU), has had an increased incidence and prevalence over the last years with a simultaneous decrease in its short-term mortality. Sepsis survivors are more frequently discharged from hospital...

...Rui Yan; Matijs van Meurs; Eliane R. Popa; Rianne M. Jongman; Peter J. Zwiers; Anita E. Niemarkt; Timara Kuiper; Jan A. Kamps; Peter Heeringa; Jan G. Zijlstra; Grietje Molema; Jill Moser Sepsis is a severe systemic inflammatory response to infection. Endothelial activation and dysfunction play...

.... [email protected] 13 01 2017 11 04 2017 23 6 2017 Lipopolysaccharide Systemic inflammatory response syndrome Sepsis Monocyte Endotoxemia Acute inflammation Monocytes perform several roles in acute inflammation: they are capable of antigen presentation...