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Keywords: Roscovitine
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Journal Articles

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Subject Area:
Topic Article Package: Pharmacology 2016 , Further Areas , Immunology and Allergy , Pathology and Cell Biology
Laurent Meijer, Deborah J. Nelson, Vladimir Riazanski, Aida G. Gabdoulkhakova, Geneviève Hery-Arnaud, Rozenn Le Berre, Nadège Loaëc, Nassima Oumata, Hervé Galons, Emmanuel Nowak, Laetitia Gueganton, Guillaume Dorothée, Michaela Prochazkova, Bradford Hall, Ashok B. Kulkarni, Robert D. Gray, Adriano G. Rossi, Véronique Witko-Sarsat, Caroline Norez, Frédéric Becq, Denis Ravel, Dominique Mottier, Gilles Rault
Journal: Journal of Innate Immunity
J Innate Immun (2016) 8 (4): 330–349.
https://doi.org/10.1159/000444256
Published Online: 18 March 2016
... G. Rossi; Véronique Witko-Sarsat; Caroline Norez; Frédéric Becq; Denis Ravel; Dominique Mottier; Gilles Rault (R)-Roscovitine, a pharmacological inhibitor of kinases, is currently in phase II clinical trial as a drug candidate for the treatment of cancers, Cushing's disease and rheumatoid arthritis...
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Journal Articles

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

Subject Area:
Further Areas , Immunology and Allergy , Pathology and Cell Biology
Sandra Moriceau, Gérard Lenoir, Véronique Witko-Sarsat
Journal: Journal of Innate Immunity
J Innate Immun (2010) 2 (3): 260–266.
https://doi.org/10.1159/000295791
Published Online: 10 March 2010
..., resulting in similar levels of constitutive and Fas-potentiated apoptosis. The cyclin-dependent kinase inhibitor roscovitine provided another approach to restore normal PMN apoptosis. However, the selective CFTR inhibitor CFTR Inh172 did not affect PMN apoptosis in control subjects. Apparently...
View article titled, In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or <span class="search-highlight">Roscovitine</span>: Evidence for an Innate Neutrophil Disturbance
Open the PDF for In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or <span class="search-highlight">Roscovitine</span>: Evidence for an Innate Neutrophil Disturbance in another window